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cuminaldehyde  (MedChemExpress)


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    Structured Review

    MedChemExpress cuminaldehyde
    HK-2 cells were treated with graded concentrations of 11-Ketodihydrotestosterone, <t>Cuminaldehyde,</t> or trans-3-Indoleacrylic acid, and viability was assessed by CCK-8. Panels ( a – c ) show cytotoxicity in unchallenged cells: ( a ) trans-3-Indoleacrylic acid (0–500 µM) was non-toxic, with 500 µM significantly enhancing viability; ( b ) Cuminaldehyde (0–1280 µM) exhibited no toxicity; ( c ) 11-Ketodihydrotestosterone (0–1000 nM) exhibited no toxicity. Panels (d–f) show protective effects in LPS-stimulated cells: ( d ) 500 µM trans-3-Indoleacrylic acid enhanced viability; ( e ) Cuminaldehyde at 128 µM and 1280 µM enhanced viability; ( f ) 11-Ketodihydrotestosterone showed no significant protective effect across 0–1000 nM. * p < 0.05 vs. Model group, ** p < 0.001 vs. Model group, **** p < 0.001 vs. Model group, ns for p > 0.05 vs. Model group.
    Cuminaldehyde, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cuminaldehyde/product/MedChemExpress
    Average 94 stars, based on 2 article reviews
    cuminaldehyde - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis"

    Article Title: Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis

    Journal: Scientific Reports

    doi: 10.1038/s41598-025-16012-6

    HK-2 cells were treated with graded concentrations of 11-Ketodihydrotestosterone, Cuminaldehyde, or trans-3-Indoleacrylic acid, and viability was assessed by CCK-8. Panels ( a – c ) show cytotoxicity in unchallenged cells: ( a ) trans-3-Indoleacrylic acid (0–500 µM) was non-toxic, with 500 µM significantly enhancing viability; ( b ) Cuminaldehyde (0–1280 µM) exhibited no toxicity; ( c ) 11-Ketodihydrotestosterone (0–1000 nM) exhibited no toxicity. Panels (d–f) show protective effects in LPS-stimulated cells: ( d ) 500 µM trans-3-Indoleacrylic acid enhanced viability; ( e ) Cuminaldehyde at 128 µM and 1280 µM enhanced viability; ( f ) 11-Ketodihydrotestosterone showed no significant protective effect across 0–1000 nM. * p < 0.05 vs. Model group, ** p < 0.001 vs. Model group, **** p < 0.001 vs. Model group, ns for p > 0.05 vs. Model group.
    Figure Legend Snippet: HK-2 cells were treated with graded concentrations of 11-Ketodihydrotestosterone, Cuminaldehyde, or trans-3-Indoleacrylic acid, and viability was assessed by CCK-8. Panels ( a – c ) show cytotoxicity in unchallenged cells: ( a ) trans-3-Indoleacrylic acid (0–500 µM) was non-toxic, with 500 µM significantly enhancing viability; ( b ) Cuminaldehyde (0–1280 µM) exhibited no toxicity; ( c ) 11-Ketodihydrotestosterone (0–1000 nM) exhibited no toxicity. Panels (d–f) show protective effects in LPS-stimulated cells: ( d ) 500 µM trans-3-Indoleacrylic acid enhanced viability; ( e ) Cuminaldehyde at 128 µM and 1280 µM enhanced viability; ( f ) 11-Ketodihydrotestosterone showed no significant protective effect across 0–1000 nM. * p < 0.05 vs. Model group, ** p < 0.001 vs. Model group, **** p < 0.001 vs. Model group, ns for p > 0.05 vs. Model group.

    Techniques Used: CCK-8 Assay

    Western blot analysis of EGFR activation and fibrotic marker expression in LPS-challenged HK-2 cells treated with 500 µM trans-3-Indoleacrylic acid or 1280 µM Cuminaldehyde. ( a ) Representative Western blot images showing p-EGFR (Tyr845), EGFR, α-SMA and β-actin expression in HK-2 cells across Sham, LPS, LPS + trans-3-Indoleacrylic acid, and LPS + Cuminaldehyde groups. ( b ) The analysis of p-EGFR (Tyr845) expression indicated that LPS markedly increased EGFR phosphorylation, whereas treatment with trans-3-Indoleacrylic acid or Cuminaldehyde significantly reduced p-EGFR levels. ( d ) EGFR expression remained unchanged across all groups. ( d ) The analysis of α-SMA expression revealed that LPS induced a pronounced upregulation of this fibrotic marker, which was significantly attenuated by both trans-3-Indoleacrylic acid and Cuminaldehyde interventions. * p < 0.05 vs. Model group, ns for p > 0.05 vs. Model group.
    Figure Legend Snippet: Western blot analysis of EGFR activation and fibrotic marker expression in LPS-challenged HK-2 cells treated with 500 µM trans-3-Indoleacrylic acid or 1280 µM Cuminaldehyde. ( a ) Representative Western blot images showing p-EGFR (Tyr845), EGFR, α-SMA and β-actin expression in HK-2 cells across Sham, LPS, LPS + trans-3-Indoleacrylic acid, and LPS + Cuminaldehyde groups. ( b ) The analysis of p-EGFR (Tyr845) expression indicated that LPS markedly increased EGFR phosphorylation, whereas treatment with trans-3-Indoleacrylic acid or Cuminaldehyde significantly reduced p-EGFR levels. ( d ) EGFR expression remained unchanged across all groups. ( d ) The analysis of α-SMA expression revealed that LPS induced a pronounced upregulation of this fibrotic marker, which was significantly attenuated by both trans-3-Indoleacrylic acid and Cuminaldehyde interventions. * p < 0.05 vs. Model group, ns for p > 0.05 vs. Model group.

    Techniques Used: Western Blot, Activation Assay, Marker, Expressing, Phospho-proteomics



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    cuminaldehyde  (MedChemExpress)
    94
    MedChemExpress cuminaldehyde
    HK-2 cells were treated with graded concentrations of 11-Ketodihydrotestosterone, <t>Cuminaldehyde,</t> or trans-3-Indoleacrylic acid, and viability was assessed by CCK-8. Panels ( a – c ) show cytotoxicity in unchallenged cells: ( a ) trans-3-Indoleacrylic acid (0–500 µM) was non-toxic, with 500 µM significantly enhancing viability; ( b ) Cuminaldehyde (0–1280 µM) exhibited no toxicity; ( c ) 11-Ketodihydrotestosterone (0–1000 nM) exhibited no toxicity. Panels (d–f) show protective effects in LPS-stimulated cells: ( d ) 500 µM trans-3-Indoleacrylic acid enhanced viability; ( e ) Cuminaldehyde at 128 µM and 1280 µM enhanced viability; ( f ) 11-Ketodihydrotestosterone showed no significant protective effect across 0–1000 nM. * p < 0.05 vs. Model group, ** p < 0.001 vs. Model group, **** p < 0.001 vs. Model group, ns for p > 0.05 vs. Model group.
    Cuminaldehyde, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cuminaldehyde/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    cuminaldehyde - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    HK-2 cells were treated with graded concentrations of 11-Ketodihydrotestosterone, Cuminaldehyde, or trans-3-Indoleacrylic acid, and viability was assessed by CCK-8. Panels ( a – c ) show cytotoxicity in unchallenged cells: ( a ) trans-3-Indoleacrylic acid (0–500 µM) was non-toxic, with 500 µM significantly enhancing viability; ( b ) Cuminaldehyde (0–1280 µM) exhibited no toxicity; ( c ) 11-Ketodihydrotestosterone (0–1000 nM) exhibited no toxicity. Panels (d–f) show protective effects in LPS-stimulated cells: ( d ) 500 µM trans-3-Indoleacrylic acid enhanced viability; ( e ) Cuminaldehyde at 128 µM and 1280 µM enhanced viability; ( f ) 11-Ketodihydrotestosterone showed no significant protective effect across 0–1000 nM. * p < 0.05 vs. Model group, ** p < 0.001 vs. Model group, **** p < 0.001 vs. Model group, ns for p > 0.05 vs. Model group.

    Journal: Scientific Reports

    Article Title: Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis

    doi: 10.1038/s41598-025-16012-6

    Figure Lengend Snippet: HK-2 cells were treated with graded concentrations of 11-Ketodihydrotestosterone, Cuminaldehyde, or trans-3-Indoleacrylic acid, and viability was assessed by CCK-8. Panels ( a – c ) show cytotoxicity in unchallenged cells: ( a ) trans-3-Indoleacrylic acid (0–500 µM) was non-toxic, with 500 µM significantly enhancing viability; ( b ) Cuminaldehyde (0–1280 µM) exhibited no toxicity; ( c ) 11-Ketodihydrotestosterone (0–1000 nM) exhibited no toxicity. Panels (d–f) show protective effects in LPS-stimulated cells: ( d ) 500 µM trans-3-Indoleacrylic acid enhanced viability; ( e ) Cuminaldehyde at 128 µM and 1280 µM enhanced viability; ( f ) 11-Ketodihydrotestosterone showed no significant protective effect across 0–1000 nM. * p < 0.05 vs. Model group, ** p < 0.001 vs. Model group, **** p < 0.001 vs. Model group, ns for p > 0.05 vs. Model group.

    Article Snippet: To establish an in vitro fibrosis model, HK-2 cells were seeded into multiwell plates and permitted to adhere overnight, after which they were exposed to 1 μg/mL lipopolysaccharide (LPS; L4391, SigmaAldrich, St. Louis, MO, USA) for 24 h. Following this induction period, treatment cohorts received 11Ketodihydrotestosterone (HY-135794, MedChemExpress, USA), Cuminaldehyde (HYY0790, MedChemExpress, USA), or trans-3Indoleacrylic acid (HYW015273A, MedChemExpress, USA) at specified concentrations for an additional 24 h in the continued presence of LPS.

    Techniques: CCK-8 Assay

    Western blot analysis of EGFR activation and fibrotic marker expression in LPS-challenged HK-2 cells treated with 500 µM trans-3-Indoleacrylic acid or 1280 µM Cuminaldehyde. ( a ) Representative Western blot images showing p-EGFR (Tyr845), EGFR, α-SMA and β-actin expression in HK-2 cells across Sham, LPS, LPS + trans-3-Indoleacrylic acid, and LPS + Cuminaldehyde groups. ( b ) The analysis of p-EGFR (Tyr845) expression indicated that LPS markedly increased EGFR phosphorylation, whereas treatment with trans-3-Indoleacrylic acid or Cuminaldehyde significantly reduced p-EGFR levels. ( d ) EGFR expression remained unchanged across all groups. ( d ) The analysis of α-SMA expression revealed that LPS induced a pronounced upregulation of this fibrotic marker, which was significantly attenuated by both trans-3-Indoleacrylic acid and Cuminaldehyde interventions. * p < 0.05 vs. Model group, ns for p > 0.05 vs. Model group.

    Journal: Scientific Reports

    Article Title: Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Guben Xiezhuo decoction against renal fibrosis

    doi: 10.1038/s41598-025-16012-6

    Figure Lengend Snippet: Western blot analysis of EGFR activation and fibrotic marker expression in LPS-challenged HK-2 cells treated with 500 µM trans-3-Indoleacrylic acid or 1280 µM Cuminaldehyde. ( a ) Representative Western blot images showing p-EGFR (Tyr845), EGFR, α-SMA and β-actin expression in HK-2 cells across Sham, LPS, LPS + trans-3-Indoleacrylic acid, and LPS + Cuminaldehyde groups. ( b ) The analysis of p-EGFR (Tyr845) expression indicated that LPS markedly increased EGFR phosphorylation, whereas treatment with trans-3-Indoleacrylic acid or Cuminaldehyde significantly reduced p-EGFR levels. ( d ) EGFR expression remained unchanged across all groups. ( d ) The analysis of α-SMA expression revealed that LPS induced a pronounced upregulation of this fibrotic marker, which was significantly attenuated by both trans-3-Indoleacrylic acid and Cuminaldehyde interventions. * p < 0.05 vs. Model group, ns for p > 0.05 vs. Model group.

    Article Snippet: To establish an in vitro fibrosis model, HK-2 cells were seeded into multiwell plates and permitted to adhere overnight, after which they were exposed to 1 μg/mL lipopolysaccharide (LPS; L4391, SigmaAldrich, St. Louis, MO, USA) for 24 h. Following this induction period, treatment cohorts received 11Ketodihydrotestosterone (HY-135794, MedChemExpress, USA), Cuminaldehyde (HYY0790, MedChemExpress, USA), or trans-3Indoleacrylic acid (HYW015273A, MedChemExpress, USA) at specified concentrations for an additional 24 h in the continued presence of LPS.

    Techniques: Western Blot, Activation Assay, Marker, Expressing, Phospho-proteomics