Journal: Journal of Gynecologic Oncology
Article Title: TET3-mediated DNA demethylation modification activates SHP2 expression to promote endometrial cancer progression through the EGFR/ERK pathway
doi: 10.3802/jgo.2024.35.e64
Figure Lengend Snippet: EC, endometrial cancer; EGFR, epidermal growth factor receptor; ERK, extracellular signal-regulated kinase; IC50, median inhibition concentration; MPA, medroxyprogesterone acetate; NC, negative control; SD, standard deviation; SHP2, src homology phosphotyrosin phosphatase 2; TET3, ten-eleven translocation 3. *,† p<0.05.
Article Snippet: EC cell lines in which SHP2 was stably knocked down were treated with the EGFR signaling pathway activator 10 μM Isoprocurcumenol (HY-113599, MedChemExpress, Monmouth Junction, NJ, USA) or DMSO (named Activator-NC thereafter) for 48 hours for subsequent experiments.
Techniques: Inhibition, Concentration Assay, Negative Control, Standard Deviation, Translocation Assay