ccz01048 peptide  (MedChemExpress)

Journal: Scientific Reports

Article Title: First-in-human dosimetry and safety evaluation of 68 Ga-αMSH derivative for PET imaging of melanoma

doi: 10.1038/s41598-025-02334-y

Figure Lengend Snippet: Chemical structure of [ 68 Ga]Ga- CCZ01048 .

Article Snippet: The CCZ01048 peptide was procured from MedChemExpress LLC (USA).

Techniques:

Journal: Scientific Reports

Article Title: First-in-human dosimetry and safety evaluation of 68 Ga-αMSH derivative for PET imaging of melanoma

doi: 10.1038/s41598-025-02334-y

Figure Lengend Snippet: HPLC chromatogram of [ 68 Ga]Ga- CCZ01048 .

Article Snippet: The CCZ01048 peptide was procured from MedChemExpress LLC (USA).

Techniques:

Journal: Scientific Reports

Article Title: First-in-human dosimetry and safety evaluation of 68 Ga-αMSH derivative for PET imaging of melanoma

doi: 10.1038/s41598-025-02334-y

Figure Lengend Snippet: A 48-year-old female with a history of rectal melanoma referred for restaging. (A, B) [ 68 Ga]Ga- CCZ01048 PET/CT images; (C, D) [ 18 F]FDG PET/CT images. The patient was diagnosed with mucosal melanoma of the perineal region, with evidence of local recurrence and extensive metastatic spread. PET/CT revealed two large tumor masses in the perineal and perirectal regions extending to the mesorectum and perisacral areas. Additionally, at least six pulmonary nodules were identified in the right lung, indicative of pulmonary metastases. Multiple mesorectal lymph nodes were also involved, suggesting lymphatic dissemination of the disease.

Article Snippet: The CCZ01048 peptide was procured from MedChemExpress LLC (USA).

Techniques: Positron Emission Tomography-Computed Tomography

Journal: Scientific Reports

Article Title: First-in-human dosimetry and safety evaluation of 68 Ga-αMSH derivative for PET imaging of melanoma

doi: 10.1038/s41598-025-02334-y

Figure Lengend Snippet: PET/CT images of a 63-year-old female patient with histologically confirmed stage IV metastatic melanoma. The patient was referred for evaluation of suspected disease progression. ( A ) Image acquired at 60 min post-injection of [ 68 Ga]Ga- CCZ01048 ; ( B ) image acquired at 120 min post-injection. The scan revealed widespread metastatic involvement, including the brain, lungs, stomach, lymph nodes, and subcutaneous tissues. Notable findings include a hypermetabolic lesion near the fourth ventricle, multiple pulmonary metastases, focal gastric wall thickening along the greater curvature, extensive lymphadenopathy in the left iliac chain, and tumor nodules in the subcutaneous fat of the foot.

Article Snippet: The CCZ01048 peptide was procured from MedChemExpress LLC (USA).

Techniques: Positron Emission Tomography-Computed Tomography, Biomarker Discovery, Injection