316243 hy 116771a  (MedChemExpress)

Journal: iScience

Article Title: Rutin alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation

doi: 10.1016/j.isci.2023.107866

Figure Lengend Snippet: Potential target analysis of rutin in the treatment of VILI (A) Network pharmacology analysis of rutin in the treatment of ventilator-induced lung injury (VILI). (B) Venn analysis of common targets of rutin in the treatment of VILI. (C) PPI analysis of connected network components.

Article Snippet: Mice in the control group were given 500 μL of PBS by intraperitoneal (i.p.) injection for three days and then were intubated without ventilation for 4 h. Mice in the VILI group were given 500 μL of PBS by i.p. injection for three days and then underwent mechanical ventilation for 4 h. Mice in the VILI + rutin group were given 500 μL of rutin (0.5 mM) by i.p. injection for three days and then underwent mechanical ventilation for 4 h. Mice in the rutin group were given 500 μL of rutin (0.5 mM) by i.p. injection for three days and then underwent intubation without ventilation for 4 h. Rutin (MCE, USA) was dissolved in DMSO, and the mice were administered an intraperitoneal (i.p.) injection in a volume of 500 μL for three consecutive days.,

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