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dpf carbamazepine  (MedChemExpress)


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    MedChemExpress dpf carbamazepine
    Dpf Carbamazepine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dpf carbamazepine/product/MedChemExpress
    Average 93 stars, based on 26 article reviews
    dpf carbamazepine - by Bioz Stars, 2026-02
    93/100 stars

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    Seizure-induced accelerated AD-like neuropathology and ERK-DAPK overactivation were alleviated by CBZ. 8-month-old PTZ-kindled 5×FAD mice were injected i.p. with 20 mg/kg CBZ or vehicle (10% DMSO) every other day (15 injections for 4 weeks), and brain tissues were harvested for analysis 24 h after the last CBZ treatment. (A) Immunohistochemical staining with an anti-Aβ antibody was conducted on paraffin-embedded hippocampal sections from vehicle- or CBZ-treated mice. Scale bar, 100 μm. (B) Quantification of Aβ42 staining intensity. N = 5. (C–E) Hippocampal lysates were subjected to Western blot analysis with anti-p-ERK, anti-ERK, anti-p-DAPK, anti-DAPK, anti-p-APP, anti-APP, anti-p-tau202/205, anti-p-tau262, anti-tau or anti-β-actin antibodies. N = 4. Statistical significance was determined by Student’s t-test (* p < 0.05; ** p < 0.01; *** p < 0.001). n.s., not significant. The data represent the mean ± SD.

    Journal: Frontiers in Pharmacology

    Article Title: Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

    doi: 10.3389/fphar.2024.1500105

    Figure Lengend Snippet: Seizure-induced accelerated AD-like neuropathology and ERK-DAPK overactivation were alleviated by CBZ. 8-month-old PTZ-kindled 5×FAD mice were injected i.p. with 20 mg/kg CBZ or vehicle (10% DMSO) every other day (15 injections for 4 weeks), and brain tissues were harvested for analysis 24 h after the last CBZ treatment. (A) Immunohistochemical staining with an anti-Aβ antibody was conducted on paraffin-embedded hippocampal sections from vehicle- or CBZ-treated mice. Scale bar, 100 μm. (B) Quantification of Aβ42 staining intensity. N = 5. (C–E) Hippocampal lysates were subjected to Western blot analysis with anti-p-ERK, anti-ERK, anti-p-DAPK, anti-DAPK, anti-p-APP, anti-APP, anti-p-tau202/205, anti-p-tau262, anti-tau or anti-β-actin antibodies. N = 4. Statistical significance was determined by Student’s t-test (* p < 0.05; ** p < 0.01; *** p < 0.001). n.s., not significant. The data represent the mean ± SD.

    Article Snippet: PTZ was purchased from MilliporeSigma (St. Louis, MO, United States), and the ERK inhibitor SL327 (HY-15437) and CBZ (HY-B0246) were obtained from MedChemExpress (NJ, United States).

    Techniques: Injection, Immunohistochemical staining, Staining, Western Blot