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sulfanilamide  (MedChemExpress)


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    MedChemExpress sulfanilamide
    Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, <t>sulfanilamide,</t> mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.
    Sulfanilamide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sulfanilamide/product/MedChemExpress
    Average 92 stars, based on 3 article reviews
    sulfanilamide - by Bioz Stars, 2026-02
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    1) Product Images from "Single-Molecule-Based, Label-Free Monitoring of Molecular Glue Efficacies for Promoting Protein–Protein Interactions Using YaxAB Nanopores"

    Article Title: Single-Molecule-Based, Label-Free Monitoring of Molecular Glue Efficacies for Promoting Protein–Protein Interactions Using YaxAB Nanopores

    Journal: ACS Nano

    doi: 10.1021/acsnano.4c11436

    Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, sulfanilamide, mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.
    Figure Legend Snippet: Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, sulfanilamide, mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.

    Techniques Used: Concentration Assay



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    Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, <t>sulfanilamide,</t> mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.
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    Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, <t>sulfanilamide,</t> mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.
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    Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, <t>sulfanilamide,</t> mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.
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    Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, sulfanilamide, mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.

    Journal: ACS Nano

    Article Title: Single-Molecule-Based, Label-Free Monitoring of Molecular Glue Efficacies for Promoting Protein–Protein Interactions Using YaxAB Nanopores

    doi: 10.1021/acsnano.4c11436

    Figure Lengend Snippet: Specific detection of rapamycin from a mixture of compounds. (a) Schematic illustration of molecular glue detection using a YaxAB-C 9 nanopore. The colored shapes symbolize nonbinding compounds (astemizole, terfenadine, capecitabine, sulfanilamide, mibefradil, pranlukast, dimantine, and monobenzone). (b–d) Representative current traces and statistical analysis of 2D scatter plots (Δ I / I o versus dwell time) and statistical histograms corresponding to the detection of mTOR, FKBP12 (b), and mTOR, FKBP12 with a mixture of nonbinding compounds in the absence (c) or presence (d) of rapamycin. All of the small-molecule compounds were treated at a concentration of 1.6 μM to the cis side of a YaxAB-C 9 nanopore. All of the electrical measurements were performed at an applied potential of +60 mV. Current traces were filtered with a Bessel (8-pole) filter at 1 kHz.

    Article Snippet: The small-molecule drugs rapamycin (914.18 g/mol, Selleckchem, Houston), ascomycin (792.01 g/mol, Selleckchem, Houston), temsirolimus (1030.29 g/mol, Selleckchem, Houston), astemizole (458.57 g/mol, MedChemExpress, New Jersey), terfenadine (471.67 g/mol, MedChemExpress), capecitabine (359.35 g/mol, MedChemExpress), sulfanilamide (172.20 g/mol, MedChemExpress), mibefradil (568.55 g/mol, MedChemExpress), pranlukast (481.50 g/mol, MedChemExpress), dimantine (297.56 g/mol, Biosynth, Staad, Germany), and monobenzone (200.23 g/mol, MedChemExpress) were dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Concentration Assay