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perindopril  (MedChemExpress)


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    MedChemExpress perindopril
    The longer-term effects of p.o delivered SPION-RLX or SPION-B7-33 vs the ACE inhibitor, <t>perindopril,</t> on measures of LV fibrosis, hypertrophy an vascular rarefaction in mice with cardiomyopathy, when administered from days 14–42 post-injury. A Shown is the mean ± SEM systolic blood pressure (SBP) for saline-injected, ISO-injected and ISO-injected + perindopril-treated mice (from n = 7 mice per group) at day 14 (prior to perindopril treatment) and day 42 (after 4-weeks of perindopril treatment). B Perl’s Prussian Blue staining of iron within the LV and liver of SPION-RLX- or B7-33-treated mice indicated that SPION-RLX or SPION-B7-33 was able to reach the target site (LV) and liver after 4-weeks of administration to ISO-injured mice. C Representative images of picrosirius red-stained LV tissue sections show the extent of interstitial collagen deposition within the LV midzone in each of the groups investigated. D – F Also shown are the mean ± SEM D %interstitial LV collagen deposition (fibrosis) per field and E LV TGF-β1 levels per field. F Representative picrosirius red-stained images also show the extent of LV cardiomyocyte size in each of the groups investigated. G The mean ± SEM LV cardiomyocyte cross sectional area in each of the groups analysed was then determined. H Representative immunohistochemically-stained sections for α-smooth muscle actin (SMA) show the extent of α-SMA-stained blood vessel density in each of the groups investigated. I Also shown is the mean ± SEM LV blood vessel density per group analysed. The data presented in panels D , E , G and I were obtained from n = 6–7 mice per group. The white coloured circles in each of the bar plots represent the individual data points per group. ** p < 0.01, *** p < 0.001 vs the saline group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs the ISO group; § p < 0.05, §§§ p < 0.001 vs the ISO + RLX-treated group; ¶ p < 0.05, ¶¶¶ p < 0.001 vs the ISO + Empty-SPION-treated group; + p < 0.05 vs the ISO + Perindoril-treated group
    Perindopril, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 10 article reviews
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    Images

    1) Product Images from "Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration"

    Article Title: Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration

    Journal: Journal of Biomedical Science

    doi: 10.1186/s12929-025-01198-8

    The longer-term effects of p.o delivered SPION-RLX or SPION-B7-33 vs the ACE inhibitor, perindopril, on measures of LV fibrosis, hypertrophy an vascular rarefaction in mice with cardiomyopathy, when administered from days 14–42 post-injury. A Shown is the mean ± SEM systolic blood pressure (SBP) for saline-injected, ISO-injected and ISO-injected + perindopril-treated mice (from n = 7 mice per group) at day 14 (prior to perindopril treatment) and day 42 (after 4-weeks of perindopril treatment). B Perl’s Prussian Blue staining of iron within the LV and liver of SPION-RLX- or B7-33-treated mice indicated that SPION-RLX or SPION-B7-33 was able to reach the target site (LV) and liver after 4-weeks of administration to ISO-injured mice. C Representative images of picrosirius red-stained LV tissue sections show the extent of interstitial collagen deposition within the LV midzone in each of the groups investigated. D – F Also shown are the mean ± SEM D %interstitial LV collagen deposition (fibrosis) per field and E LV TGF-β1 levels per field. F Representative picrosirius red-stained images also show the extent of LV cardiomyocyte size in each of the groups investigated. G The mean ± SEM LV cardiomyocyte cross sectional area in each of the groups analysed was then determined. H Representative immunohistochemically-stained sections for α-smooth muscle actin (SMA) show the extent of α-SMA-stained blood vessel density in each of the groups investigated. I Also shown is the mean ± SEM LV blood vessel density per group analysed. The data presented in panels D , E , G and I were obtained from n = 6–7 mice per group. The white coloured circles in each of the bar plots represent the individual data points per group. ** p < 0.01, *** p < 0.001 vs the saline group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs the ISO group; § p < 0.05, §§§ p < 0.001 vs the ISO + RLX-treated group; ¶ p < 0.05, ¶¶¶ p < 0.001 vs the ISO + Empty-SPION-treated group; + p < 0.05 vs the ISO + Perindoril-treated group
    Figure Legend Snippet: The longer-term effects of p.o delivered SPION-RLX or SPION-B7-33 vs the ACE inhibitor, perindopril, on measures of LV fibrosis, hypertrophy an vascular rarefaction in mice with cardiomyopathy, when administered from days 14–42 post-injury. A Shown is the mean ± SEM systolic blood pressure (SBP) for saline-injected, ISO-injected and ISO-injected + perindopril-treated mice (from n = 7 mice per group) at day 14 (prior to perindopril treatment) and day 42 (after 4-weeks of perindopril treatment). B Perl’s Prussian Blue staining of iron within the LV and liver of SPION-RLX- or B7-33-treated mice indicated that SPION-RLX or SPION-B7-33 was able to reach the target site (LV) and liver after 4-weeks of administration to ISO-injured mice. C Representative images of picrosirius red-stained LV tissue sections show the extent of interstitial collagen deposition within the LV midzone in each of the groups investigated. D – F Also shown are the mean ± SEM D %interstitial LV collagen deposition (fibrosis) per field and E LV TGF-β1 levels per field. F Representative picrosirius red-stained images also show the extent of LV cardiomyocyte size in each of the groups investigated. G The mean ± SEM LV cardiomyocyte cross sectional area in each of the groups analysed was then determined. H Representative immunohistochemically-stained sections for α-smooth muscle actin (SMA) show the extent of α-SMA-stained blood vessel density in each of the groups investigated. I Also shown is the mean ± SEM LV blood vessel density per group analysed. The data presented in panels D , E , G and I were obtained from n = 6–7 mice per group. The white coloured circles in each of the bar plots represent the individual data points per group. ** p < 0.01, *** p < 0.001 vs the saline group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs the ISO group; § p < 0.05, §§§ p < 0.001 vs the ISO + RLX-treated group; ¶ p < 0.05, ¶¶¶ p < 0.001 vs the ISO + Empty-SPION-treated group; + p < 0.05 vs the ISO + Perindoril-treated group

    Techniques Used: Saline, Injection, Staining



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    Image Search Results


    The longer-term effects of p.o delivered SPION-RLX or SPION-B7-33 vs the ACE inhibitor, perindopril, on measures of LV fibrosis, hypertrophy an vascular rarefaction in mice with cardiomyopathy, when administered from days 14–42 post-injury. A Shown is the mean ± SEM systolic blood pressure (SBP) for saline-injected, ISO-injected and ISO-injected + perindopril-treated mice (from n = 7 mice per group) at day 14 (prior to perindopril treatment) and day 42 (after 4-weeks of perindopril treatment). B Perl’s Prussian Blue staining of iron within the LV and liver of SPION-RLX- or B7-33-treated mice indicated that SPION-RLX or SPION-B7-33 was able to reach the target site (LV) and liver after 4-weeks of administration to ISO-injured mice. C Representative images of picrosirius red-stained LV tissue sections show the extent of interstitial collagen deposition within the LV midzone in each of the groups investigated. D – F Also shown are the mean ± SEM D %interstitial LV collagen deposition (fibrosis) per field and E LV TGF-β1 levels per field. F Representative picrosirius red-stained images also show the extent of LV cardiomyocyte size in each of the groups investigated. G The mean ± SEM LV cardiomyocyte cross sectional area in each of the groups analysed was then determined. H Representative immunohistochemically-stained sections for α-smooth muscle actin (SMA) show the extent of α-SMA-stained blood vessel density in each of the groups investigated. I Also shown is the mean ± SEM LV blood vessel density per group analysed. The data presented in panels D , E , G and I were obtained from n = 6–7 mice per group. The white coloured circles in each of the bar plots represent the individual data points per group. ** p < 0.01, *** p < 0.001 vs the saline group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs the ISO group; § p < 0.05, §§§ p < 0.001 vs the ISO + RLX-treated group; ¶ p < 0.05, ¶¶¶ p < 0.001 vs the ISO + Empty-SPION-treated group; + p < 0.05 vs the ISO + Perindoril-treated group

    Journal: Journal of Biomedical Science

    Article Title: Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administration

    doi: 10.1186/s12929-025-01198-8

    Figure Lengend Snippet: The longer-term effects of p.o delivered SPION-RLX or SPION-B7-33 vs the ACE inhibitor, perindopril, on measures of LV fibrosis, hypertrophy an vascular rarefaction in mice with cardiomyopathy, when administered from days 14–42 post-injury. A Shown is the mean ± SEM systolic blood pressure (SBP) for saline-injected, ISO-injected and ISO-injected + perindopril-treated mice (from n = 7 mice per group) at day 14 (prior to perindopril treatment) and day 42 (after 4-weeks of perindopril treatment). B Perl’s Prussian Blue staining of iron within the LV and liver of SPION-RLX- or B7-33-treated mice indicated that SPION-RLX or SPION-B7-33 was able to reach the target site (LV) and liver after 4-weeks of administration to ISO-injured mice. C Representative images of picrosirius red-stained LV tissue sections show the extent of interstitial collagen deposition within the LV midzone in each of the groups investigated. D – F Also shown are the mean ± SEM D %interstitial LV collagen deposition (fibrosis) per field and E LV TGF-β1 levels per field. F Representative picrosirius red-stained images also show the extent of LV cardiomyocyte size in each of the groups investigated. G The mean ± SEM LV cardiomyocyte cross sectional area in each of the groups analysed was then determined. H Representative immunohistochemically-stained sections for α-smooth muscle actin (SMA) show the extent of α-SMA-stained blood vessel density in each of the groups investigated. I Also shown is the mean ± SEM LV blood vessel density per group analysed. The data presented in panels D , E , G and I were obtained from n = 6–7 mice per group. The white coloured circles in each of the bar plots represent the individual data points per group. ** p < 0.01, *** p < 0.001 vs the saline group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs the ISO group; § p < 0.05, §§§ p < 0.001 vs the ISO + RLX-treated group; ¶ p < 0.05, ¶¶¶ p < 0.001 vs the ISO + Empty-SPION-treated group; + p < 0.05 vs the ISO + Perindoril-treated group

    Article Snippet: Perindopril was purchased from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques: Saline, Injection, Staining