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artemisinin (MedChemExpress)

Name: artemisinin
Brand: MedChemExpress
Rating: 94 (33 reviews)

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MedChemExpress artemisinin

<t>Artemisinin,</t> a ligand of RAB40C, displayed a promising potential in HCC therapy. A A 2D model of binding of artemisinin to amino acid residues of RAB40C. B 3D model of RAB40C’s optimal binding mechanism in the protein pocket (artemisinin depicted as colored sticks). C Amino acid residues of RAB40C interacting with the artemisinin in 3D (color sticks). D , E The inhibition effect of artemisinin on EGFR was detected by western blot. F The k63-linked ubiquitination of EGFR by artemisinin was detected by IP analysis. G , H The inhibitory effect of artemisinin on cell viability of HepG2 and Huh7 cells by colony formation assay

Artemisinin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 33 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/artemisinin/product/MedChemExpress
Average 94 stars, based on 33 article reviews

artemisinin - by Bioz Stars, 2026-02

94/100 stars

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1) Product Images from "RAB40C recruiting TRIM21 facilitates the progression of hepatocellular carcinoma by stabilizing EGFR"

Article Title: RAB40C recruiting TRIM21 facilitates the progression of hepatocellular carcinoma by stabilizing EGFR

Journal: Cell Communication and Signaling : CCS

doi: 10.1186/s12964-025-02580-7

Artemisinin, a ligand of RAB40C, displayed a promising potential in HCC therapy. A A 2D model of binding of artemisinin to amino acid residues of RAB40C. B 3D model of RAB40C’s optimal binding mechanism in the protein pocket (artemisinin depicted as colored sticks). C Amino acid residues of RAB40C interacting with the artemisinin in 3D (color sticks). D , E The inhibition effect of artemisinin on EGFR was detected by western blot. F The k63-linked ubiquitination of EGFR by artemisinin was detected by IP analysis. G , H The inhibitory effect of artemisinin on cell viability of HepG2 and Huh7 cells by colony formation assay

Figure Legend Snippet: Artemisinin, a ligand of RAB40C, displayed a promising potential in HCC therapy. A A 2D model of binding of artemisinin to amino acid residues of RAB40C. B 3D model of RAB40C’s optimal binding mechanism in the protein pocket (artemisinin depicted as colored sticks). C Amino acid residues of RAB40C interacting with the artemisinin in 3D (color sticks). D , E The inhibition effect of artemisinin on EGFR was detected by western blot. F The k63-linked ubiquitination of EGFR by artemisinin was detected by IP analysis. G , H The inhibitory effect of artemisinin on cell viability of HepG2 and Huh7 cells by colony formation assay

Techniques Used: Binding Assay, Inhibition, Western Blot, Ubiquitin Proteomics, Colony Assay

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Journal: Cell Communication and Signaling : CCS

Article Title: RAB40C recruiting TRIM21 facilitates the progression of hepatocellular carcinoma by stabilizing EGFR

doi: 10.1186/s12964-025-02580-7

Figure Lengend Snippet: Artemisinin, a ligand of RAB40C, displayed a promising potential in HCC therapy. A A 2D model of binding of artemisinin to amino acid residues of RAB40C. B 3D model of RAB40C’s optimal binding mechanism in the protein pocket (artemisinin depicted as colored sticks). C Amino acid residues of RAB40C interacting with the artemisinin in 3D (color sticks). D , E The inhibition effect of artemisinin on EGFR was detected by western blot. F The k63-linked ubiquitination of EGFR by artemisinin was detected by IP analysis. G , H The inhibitory effect of artemisinin on cell viability of HepG2 and Huh7 cells by colony formation assay

Article Snippet: Artemisinin (HY-B0094) was s purchased from MedChemExpress.

Techniques: Binding Assay, Inhibition, Western Blot, Ubiquitin Proteomics, Colony Assay

$Tandem mass spectra of arteannuin B and artemisinin acquired by ESI-QTOF-MS/MS in positive ion mode. Representative MS/MS spectra used to confirm the identity of the target sesquiterpenoids detected in the Artemisia annua ethanolic extract and subsequent fractions. Panels show the characteristic fragmentation patterns of (A) arteannuin B with precursor ion [M+H] + at m/z 249; and (B) Artemisinin with precursor ion [M+H] + at m/z 283. The observed fragment ions match literature and reference standard data, supporting confident identification and the selectivity of the downstream HSCCC fractionation. MS/MS: Tandem mass spectrometry; ESI: Electrospray ionization; QTOF: Quadrupole time-of-flight; HSCCC: High-speed counter-current chromatography; m/z: Mass-to-charge ratio.$

Journal: Biomolecules and Biomedicine

Article Title: Profiling of sesquiterpenoid fractions from Artemisia annua L. and testing their in vitro anti-SARS-CoV-2 activity

doi: 10.17305/bb.2025.12052

Figure Lengend Snippet: Tandem mass spectra of arteannuin B and artemisinin acquired by ESI-QTOF-MS/MS in positive ion mode. Representative MS/MS spectra used to confirm the identity of the target sesquiterpenoids detected in the Artemisia annua ethanolic extract and subsequent fractions. Panels show the characteristic fragmentation patterns of (A) arteannuin B with precursor ion [M+H] + at m/z 249; and (B) Artemisinin with precursor ion [M+H] + at m/z 283. The observed fragment ions match literature and reference standard data, supporting confident identification and the selectivity of the downstream HSCCC fractionation. MS/MS: Tandem mass spectrometry; ESI: Electrospray ionization; QTOF: Quadrupole time-of-flight; HSCCC: High-speed counter-current chromatography; m/z: Mass-to-charge ratio.

Article Snippet: Authentic artemisinin and arteannuin B standards for compound identification were obtained from Sigma-Aldrich and MedChemExpress.

Techniques: Tandem Mass Spectroscopy, High Speed Counter-current Chromatography, Fractionation, Mass Spectrometry

$TIC of the crude EtOH extract of Artemisia annua and EIC of arteannuin B. The TIC profile of the crude ethanolic leaf extract (top) provides a molecular fingerprint of the complex mixture, highlighting multiple constituents. The EIC at m/z 249 [M+H] + (bottom) confirms the presence of arteannuin B, detected as a distinct peak at 8.63 min. These results verify arteannuin B as one of the main compounds in the crude extract, thereby supporting its targeted isolation and further fractionation. TIC: Total ion chromatogram; EIC: Extracted ion chromatogram; EtOH: Ethanol; min: Retention time in minutes; m/z: Mass-to-charge ratio; [M+H] + : Protonated molecular ion.$

Journal: Biomolecules and Biomedicine

Article Title: Profiling of sesquiterpenoid fractions from Artemisia annua L. and testing their in vitro anti-SARS-CoV-2 activity

doi: 10.17305/bb.2025.12052

Figure Lengend Snippet: TIC of the crude EtOH extract of Artemisia annua and EIC of arteannuin B. The TIC profile of the crude ethanolic leaf extract (top) provides a molecular fingerprint of the complex mixture, highlighting multiple constituents. The EIC at m/z 249 [M+H] + (bottom) confirms the presence of arteannuin B, detected as a distinct peak at 8.63 min. These results verify arteannuin B as one of the main compounds in the crude extract, thereby supporting its targeted isolation and further fractionation. TIC: Total ion chromatogram; EIC: Extracted ion chromatogram; EtOH: Ethanol; min: Retention time in minutes; m/z: Mass-to-charge ratio; [M+H] + : Protonated molecular ion.

Article Snippet: Authentic artemisinin and arteannuin B standards for compound identification were obtained from Sigma-Aldrich and MedChemExpress.

Techniques: Isolation, Fractionation

$TIC and EIC of the artemisinin knockout fraction of Artemisia annua . The TIC (top) shows the overall chemical profile of the fraction. The EIC at m/z 249 [M+H] + (middle) confirms arteannuin B at 8.48 min, while the EIC at m/z 305 [M+Na] + (bottom) demonstrates the absence of artemisinin, confirming the selectivity of the fractionation. TIC: Total ion chromatogram; EIC: Extracted ion chromatogram; m/z: Mass-to-charge ratio; [M+H] + : Protonated molecular ion; [M+Na] + : Sodium adduct ion.$

Journal: Biomolecules and Biomedicine

Article Title: Profiling of sesquiterpenoid fractions from Artemisia annua L. and testing their in vitro anti-SARS-CoV-2 activity

doi: 10.17305/bb.2025.12052

Figure Lengend Snippet: TIC and EIC of the artemisinin knockout fraction of Artemisia annua . The TIC (top) shows the overall chemical profile of the fraction. The EIC at m/z 249 [M+H] + (middle) confirms arteannuin B at 8.48 min, while the EIC at m/z 305 [M+Na] + (bottom) demonstrates the absence of artemisinin, confirming the selectivity of the fractionation. TIC: Total ion chromatogram; EIC: Extracted ion chromatogram; m/z: Mass-to-charge ratio; [M+H] + : Protonated molecular ion; [M+Na] + : Sodium adduct ion.

Article Snippet: Authentic artemisinin and arteannuin B standards for compound identification were obtained from Sigma-Aldrich and MedChemExpress.

Techniques: Knock-Out, Fractionation

$Comparative ESI-QTOF-MS/MS spectra (positive ion mode) of arteannuin B: HSCCC fraction vs. reference standard. Overlaid MS/MS spectra for the precursor ion m/z 249 [M+H] + from the arteannuin B fraction (top) and the pure compound (bottom) show matching fragmentation patterns, confirming unambiguous identification and high purity of the isolated fraction obtained by HSCCC. ESI: Electrospray ionization; QTOF: Quadrupole time-of-flight; MS/MS: Tandem mass spectrometry; HSCCC: High-speed counter-current chromatography; m/z: Mass-to-charge ratio; [M+H] + : Protonated molecular ion.$

Journal: Biomolecules and Biomedicine

Article Title: Profiling of sesquiterpenoid fractions from Artemisia annua L. and testing their in vitro anti-SARS-CoV-2 activity

doi: 10.17305/bb.2025.12052

Figure Lengend Snippet: Comparative ESI-QTOF-MS/MS spectra (positive ion mode) of arteannuin B: HSCCC fraction vs. reference standard. Overlaid MS/MS spectra for the precursor ion m/z 249 [M+H] + from the arteannuin B fraction (top) and the pure compound (bottom) show matching fragmentation patterns, confirming unambiguous identification and high purity of the isolated fraction obtained by HSCCC. ESI: Electrospray ionization; QTOF: Quadrupole time-of-flight; MS/MS: Tandem mass spectrometry; HSCCC: High-speed counter-current chromatography; m/z: Mass-to-charge ratio; [M+H] + : Protonated molecular ion.

Article Snippet: Authentic artemisinin and arteannuin B standards for compound identification were obtained from Sigma-Aldrich and MedChemExpress.

Techniques: Tandem Mass Spectroscopy, High Speed Counter-current Chromatography, Isolation, Mass Spectrometry

$Normalized inhibition (%) of the Alpha variant (B.1.1.7 + Q.*; hCoV-19/Bosnia and Herzegovina/VFS-UNSA-LMGFI031/2021; GISAID accession ID: EPI_ISL_1016969) determined by quantitative real-time PCR after exposure of Vero E6 infected monolayers to different concentrations of each tested Artemisia annua L. sample for 48 h. Samples (A) A. annua L. SC-CO 2 extract; (B) A. annua L. EtOH extract; (C) Artemisinin knockout fraction; (D) Arteannuin B fraction; (E) Artemisinin. Data are presented as means of independent replicates ± standard deviations. Statistically significant differences compared to controls (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).$

Journal: Biomolecules and Biomedicine

Article Title: Profiling of sesquiterpenoid fractions from Artemisia annua L. and testing their in vitro anti-SARS-CoV-2 activity

doi: 10.17305/bb.2025.12052

Figure Lengend Snippet: Normalized inhibition (%) of the Alpha variant (B.1.1.7 + Q.*; hCoV-19/Bosnia and Herzegovina/VFS-UNSA-LMGFI031/2021; GISAID accession ID: EPI_ISL_1016969) determined by quantitative real-time PCR after exposure of Vero E6 infected monolayers to different concentrations of each tested Artemisia annua L. sample for 48 h. Samples (A) A. annua L. SC-CO 2 extract; (B) A. annua L. EtOH extract; (C) Artemisinin knockout fraction; (D) Arteannuin B fraction; (E) Artemisinin. Data are presented as means of independent replicates ± standard deviations. Statistically significant differences compared to controls (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).

Article Snippet: Authentic artemisinin and arteannuin B standards for compound identification were obtained from Sigma-Aldrich and MedChemExpress.

Techniques: Inhibition, Variant Assay, Real-time Polymerase Chain Reaction, Infection, Knock-Out

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1) Product Images from "RAB40C recruiting TRIM21 facilitates the progression of hepatocellular carcinoma by stabilizing EGFR"

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