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ruxolitinib  (MedChemExpress)


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    MedChemExpress ruxolitinib
    (A) Representative pictures from organoid cultures for established WT FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) Estradiol (E2) treatment (1nM). Scale bars=50μm. (B) Quantification of sizes and numbers (at different size ranges) of organoids formed from different cultures as in (A). *: p≤0.05, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (C) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in FTE organoid cells from the indicated cultures in relation to those from the WT FTE only culture (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (D-E) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in FTE cells from the FTE+SC+E2 cultures in relation to those from the FTE+SC cultures (D), or in FTE cells from the FTE+SC cultures in relation to those from the FTE only cultures (E). Gene sets related to inflammation/immune pathways are highlighted. (F) Quantification of sizes of organoids formed from established WT FTE organoid cells co-cultured with MACS-sorted FT stromal cells from PcY (lef) or PEY (right) mice with or without E2 treatment (1nM). Representative organoid pictures are shown in Figure S6D. ***: p≤0.001, ****: p≤0.0001, ns = not significant, Student’s t-test. Error bar represents ±SEM. (G) ATP assay data for organoids in and S6D. *: p≤0.05, **: p≤0.01, by Student’s t-test. Error bar represents ±SEM. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of <t>Ruxolitinib</t> for 7 days. (J) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 3 days. (K) qRT-PCR analysis of Foxj1 expression in organoids from J treated with different concentrations of Ruxolitinib for 3 days.
    Ruxolitinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 139 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ruxolitinib/product/MedChemExpress
    Average 96 stars, based on 139 article reviews
    ruxolitinib - by Bioz Stars, 2026-02
    96/100 stars

    Images

    1) Product Images from "Stromal estrogen signaling regulates fallopian tube homeostasis and cancer initiation via inflammatory pathways"

    Article Title: Stromal estrogen signaling regulates fallopian tube homeostasis and cancer initiation via inflammatory pathways

    Journal: bioRxiv

    doi: 10.64898/2026.01.21.700864

    (A) Representative pictures from organoid cultures for established WT FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) Estradiol (E2) treatment (1nM). Scale bars=50μm. (B) Quantification of sizes and numbers (at different size ranges) of organoids formed from different cultures as in (A). *: p≤0.05, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (C) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in FTE organoid cells from the indicated cultures in relation to those from the WT FTE only culture (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (D-E) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in FTE cells from the FTE+SC+E2 cultures in relation to those from the FTE+SC cultures (D), or in FTE cells from the FTE+SC cultures in relation to those from the FTE only cultures (E). Gene sets related to inflammation/immune pathways are highlighted. (F) Quantification of sizes of organoids formed from established WT FTE organoid cells co-cultured with MACS-sorted FT stromal cells from PcY (lef) or PEY (right) mice with or without E2 treatment (1nM). Representative organoid pictures are shown in Figure S6D. ***: p≤0.001, ****: p≤0.0001, ns = not significant, Student’s t-test. Error bar represents ±SEM. (G) ATP assay data for organoids in and S6D. *: p≤0.05, **: p≤0.01, by Student’s t-test. Error bar represents ±SEM. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days. (J) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 3 days. (K) qRT-PCR analysis of Foxj1 expression in organoids from J treated with different concentrations of Ruxolitinib for 3 days.
    Figure Legend Snippet: (A) Representative pictures from organoid cultures for established WT FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) Estradiol (E2) treatment (1nM). Scale bars=50μm. (B) Quantification of sizes and numbers (at different size ranges) of organoids formed from different cultures as in (A). *: p≤0.05, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (C) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in FTE organoid cells from the indicated cultures in relation to those from the WT FTE only culture (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (D-E) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in FTE cells from the FTE+SC+E2 cultures in relation to those from the FTE+SC cultures (D), or in FTE cells from the FTE+SC cultures in relation to those from the FTE only cultures (E). Gene sets related to inflammation/immune pathways are highlighted. (F) Quantification of sizes of organoids formed from established WT FTE organoid cells co-cultured with MACS-sorted FT stromal cells from PcY (lef) or PEY (right) mice with or without E2 treatment (1nM). Representative organoid pictures are shown in Figure S6D. ***: p≤0.001, ****: p≤0.0001, ns = not significant, Student’s t-test. Error bar represents ±SEM. (G) ATP assay data for organoids in and S6D. *: p≤0.05, **: p≤0.01, by Student’s t-test. Error bar represents ±SEM. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days. (J) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 3 days. (K) qRT-PCR analysis of Foxj1 expression in organoids from J treated with different concentrations of Ruxolitinib for 3 days.

    Techniques Used: Cell Culture, ATP Assay, Quantitative RT-PCR, Expressing

    (A) Representative pictures from organoid cultures for established PBP -null FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) E2 treatment (1nM). Scale bars=50μm. (B) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE) (as baseline, =0). (C) GSEA showing enrichment of the cell cycle-related Hallmark gene set in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE). (D) Quantification of sizes and numbers (at different size ranges) of organoids in (A). **: p≤0.01, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (E) ATP assay of organoids in (A). *: p≤0.05, **: p≤0.01, Student’s t-test. Error bar represents ±SEM. (F) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells from the indicated cultures in relation to those from the PBP -null FTE only cultures (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (G) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in PBP -null FTE cells in relation to WT FTE cells (left) and in PBP -null FTE cells from the FTE+SC+E2 culture in relation to those from the FTE+SC culture (right). Gene sets related to inflammation/immune pathways are highlighted. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days.
    Figure Legend Snippet: (A) Representative pictures from organoid cultures for established PBP -null FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) E2 treatment (1nM). Scale bars=50μm. (B) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE) (as baseline, =0). (C) GSEA showing enrichment of the cell cycle-related Hallmark gene set in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE). (D) Quantification of sizes and numbers (at different size ranges) of organoids in (A). **: p≤0.01, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (E) ATP assay of organoids in (A). *: p≤0.05, **: p≤0.01, Student’s t-test. Error bar represents ±SEM. (F) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells from the indicated cultures in relation to those from the PBP -null FTE only cultures (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (G) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in PBP -null FTE cells in relation to WT FTE cells (left) and in PBP -null FTE cells from the FTE+SC+E2 culture in relation to those from the FTE+SC culture (right). Gene sets related to inflammation/immune pathways are highlighted. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days.

    Techniques Used: Cell Culture, ATP Assay



    Similar Products

    ruxolitinib  (MedChemExpress)
    96
    MedChemExpress ruxolitinib
    (A) Representative pictures from organoid cultures for established WT FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) Estradiol (E2) treatment (1nM). Scale bars=50μm. (B) Quantification of sizes and numbers (at different size ranges) of organoids formed from different cultures as in (A). *: p≤0.05, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (C) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in FTE organoid cells from the indicated cultures in relation to those from the WT FTE only culture (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (D-E) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in FTE cells from the FTE+SC+E2 cultures in relation to those from the FTE+SC cultures (D), or in FTE cells from the FTE+SC cultures in relation to those from the FTE only cultures (E). Gene sets related to inflammation/immune pathways are highlighted. (F) Quantification of sizes of organoids formed from established WT FTE organoid cells co-cultured with MACS-sorted FT stromal cells from PcY (lef) or PEY (right) mice with or without E2 treatment (1nM). Representative organoid pictures are shown in Figure S6D. ***: p≤0.001, ****: p≤0.0001, ns = not significant, Student’s t-test. Error bar represents ±SEM. (G) ATP assay data for organoids in and S6D. *: p≤0.05, **: p≤0.01, by Student’s t-test. Error bar represents ±SEM. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of <t>Ruxolitinib</t> for 7 days. (J) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 3 days. (K) qRT-PCR analysis of Foxj1 expression in organoids from J treated with different concentrations of Ruxolitinib for 3 days.
    Ruxolitinib, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ruxolitinib/product/MedChemExpress
    Average 96 stars, based on 1 article reviews
    ruxolitinib - by Bioz Stars, 2026-02
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Representative pictures from organoid cultures for established WT FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) Estradiol (E2) treatment (1nM). Scale bars=50μm. (B) Quantification of sizes and numbers (at different size ranges) of organoids formed from different cultures as in (A). *: p≤0.05, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (C) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in FTE organoid cells from the indicated cultures in relation to those from the WT FTE only culture (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (D-E) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in FTE cells from the FTE+SC+E2 cultures in relation to those from the FTE+SC cultures (D), or in FTE cells from the FTE+SC cultures in relation to those from the FTE only cultures (E). Gene sets related to inflammation/immune pathways are highlighted. (F) Quantification of sizes of organoids formed from established WT FTE organoid cells co-cultured with MACS-sorted FT stromal cells from PcY (lef) or PEY (right) mice with or without E2 treatment (1nM). Representative organoid pictures are shown in Figure S6D. ***: p≤0.001, ****: p≤0.0001, ns = not significant, Student’s t-test. Error bar represents ±SEM. (G) ATP assay data for organoids in and S6D. *: p≤0.05, **: p≤0.01, by Student’s t-test. Error bar represents ±SEM. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days. (J) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 3 days. (K) qRT-PCR analysis of Foxj1 expression in organoids from J treated with different concentrations of Ruxolitinib for 3 days.

    Journal: bioRxiv

    Article Title: Stromal estrogen signaling regulates fallopian tube homeostasis and cancer initiation via inflammatory pathways

    doi: 10.64898/2026.01.21.700864

    Figure Lengend Snippet: (A) Representative pictures from organoid cultures for established WT FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) Estradiol (E2) treatment (1nM). Scale bars=50μm. (B) Quantification of sizes and numbers (at different size ranges) of organoids formed from different cultures as in (A). *: p≤0.05, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (C) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in FTE organoid cells from the indicated cultures in relation to those from the WT FTE only culture (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (D-E) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in FTE cells from the FTE+SC+E2 cultures in relation to those from the FTE+SC cultures (D), or in FTE cells from the FTE+SC cultures in relation to those from the FTE only cultures (E). Gene sets related to inflammation/immune pathways are highlighted. (F) Quantification of sizes of organoids formed from established WT FTE organoid cells co-cultured with MACS-sorted FT stromal cells from PcY (lef) or PEY (right) mice with or without E2 treatment (1nM). Representative organoid pictures are shown in Figure S6D. ***: p≤0.001, ****: p≤0.0001, ns = not significant, Student’s t-test. Error bar represents ±SEM. (G) ATP assay data for organoids in and S6D. *: p≤0.05, **: p≤0.01, by Student’s t-test. Error bar represents ±SEM. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days. (J) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 3 days. (K) qRT-PCR analysis of Foxj1 expression in organoids from J treated with different concentrations of Ruxolitinib for 3 days.

    Article Snippet: 1nM 17β-Estradiol (Sigma-Aldrich #3301-1GM), JSH-23 (MedChem Express # HY-13982), BMS-195614 (MedChem Express # HY-101259) and Ruxolitinib (MedChem Express #HY-50856) were added to culture medium.

    Techniques: Cell Culture, ATP Assay, Quantitative RT-PCR, Expressing

    (A) Representative pictures from organoid cultures for established PBP -null FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) E2 treatment (1nM). Scale bars=50μm. (B) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE) (as baseline, =0). (C) GSEA showing enrichment of the cell cycle-related Hallmark gene set in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE). (D) Quantification of sizes and numbers (at different size ranges) of organoids in (A). **: p≤0.01, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (E) ATP assay of organoids in (A). *: p≤0.05, **: p≤0.01, Student’s t-test. Error bar represents ±SEM. (F) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells from the indicated cultures in relation to those from the PBP -null FTE only cultures (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (G) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in PBP -null FTE cells in relation to WT FTE cells (left) and in PBP -null FTE cells from the FTE+SC+E2 culture in relation to those from the FTE+SC culture (right). Gene sets related to inflammation/immune pathways are highlighted. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days.

    Journal: bioRxiv

    Article Title: Stromal estrogen signaling regulates fallopian tube homeostasis and cancer initiation via inflammatory pathways

    doi: 10.64898/2026.01.21.700864

    Figure Lengend Snippet: (A) Representative pictures from organoid cultures for established PBP -null FTE organoid cells growing in the BET medium alone (FTE only) or co-cultured with WT FT stromal cells (SC) with (FTE+SC+E2) or without (FTE+SC) E2 treatment (1nM). Scale bars=50μm. (B) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE) (as baseline, =0). (C) GSEA showing enrichment of the cell cycle-related Hallmark gene set in PBP -null FTE organoid cells (PBP_FTE) in relation to WT FTE organoid cells (WT_FTE). (D) Quantification of sizes and numbers (at different size ranges) of organoids in (A). **: p≤0.01, ****: p≤0.0001, Student’s t-test. Error bar represents ±SEM. (E) ATP assay of organoids in (A). *: p≤0.05, **: p≤0.01, Student’s t-test. Error bar represents ±SEM. (F) Relative enrichment or depletion (based on GSEA) of the indicated gene sets for FTE lineages (#1-10) based on human single-cell dataset in Dinh et al in PBP -null FTE organoid cells from the indicated cultures in relation to those from the PBP -null FTE only cultures (as baseline, =0). Arrows indicate E2-induced FTE lineage changes in FTE+SC+E2 cultures in relation to the FTE+SC cultures. (G) GSEA data showing top enriched gene sets in the Hallmark collection from the MSigDB in PBP -null FTE cells in relation to WT FTE cells (left) and in PBP -null FTE cells from the FTE+SC+E2 culture in relation to those from the FTE+SC culture (right). Gene sets related to inflammation/immune pathways are highlighted. (H) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of JSH-23 for 7 days. AUC=area under the curve. (I) Linear regression curves of ATP assay for organoids from the indicated culture conditions treated with different concentrations of Ruxolitinib for 7 days.

    Article Snippet: 1nM 17β-Estradiol (Sigma-Aldrich #3301-1GM), JSH-23 (MedChem Express # HY-13982), BMS-195614 (MedChem Express # HY-101259) and Ruxolitinib (MedChem Express #HY-50856) were added to culture medium.

    Techniques: Cell Culture, ATP Assay