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cilobradine  (MedChemExpress)


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    MedChemExpress cilobradine
    Mild inhibition of BRV on hyperpolarization-activated cationic current ( I h ) in GH 3 cells. The experiments were conducted in cells immersed in Ca 2+ -free Tyrode’s solution containing 1 µM tetrodotoxin, where the pipette was filled with a K + -containing solution comprising K-aspartate 130 mM, KCl 20 mM, MgCl 2 1 mM, Na 2 ATP 3 mM, Na 2 GTP 0.1 mM, EGTA 0.1 mM, and HEPES 5 mM adjusted to pH 7.2 with KOH. ( A ) Representative I h traces activated by a 2 s hyperpolarizing voltage pulse ranging from −40 to −120 mV (indicated in the upper part of the figure). (1): control, (2): 10 µM BRV, and (3): 10 µM BRV plus 3 µM <t>cilobradine</t> (Cil); ( B ) Summary bar graph showing the effects of BRV and BRV plus cilobradine (Cil) in hyperpolarization-activated I h (mean ± SEM; n = 8). The current amplitude was measured at the endpoint of a 2 s hyperpolarizing pulse ranging from −40 to −120 mV. * indicates significantly different from control ( p < 0.05) and † indicates signficantly different from BRV (10 mM) alone group ( p < 0.05).
    Cilobradine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cilobradine/product/MedChemExpress
    Average 91 stars, based on 1 article reviews
    cilobradine - by Bioz Stars, 2026-02
    91/100 stars

    Images

    1) Product Images from "The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability"

    Article Title: The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability

    Journal: Biomedicines

    doi: 10.3390/biomedicines9040369

    Mild inhibition of BRV on hyperpolarization-activated cationic current ( I h ) in GH 3 cells. The experiments were conducted in cells immersed in Ca 2+ -free Tyrode’s solution containing 1 µM tetrodotoxin, where the pipette was filled with a K + -containing solution comprising K-aspartate 130 mM, KCl 20 mM, MgCl 2 1 mM, Na 2 ATP 3 mM, Na 2 GTP 0.1 mM, EGTA 0.1 mM, and HEPES 5 mM adjusted to pH 7.2 with KOH. ( A ) Representative I h traces activated by a 2 s hyperpolarizing voltage pulse ranging from −40 to −120 mV (indicated in the upper part of the figure). (1): control, (2): 10 µM BRV, and (3): 10 µM BRV plus 3 µM cilobradine (Cil); ( B ) Summary bar graph showing the effects of BRV and BRV plus cilobradine (Cil) in hyperpolarization-activated I h (mean ± SEM; n = 8). The current amplitude was measured at the endpoint of a 2 s hyperpolarizing pulse ranging from −40 to −120 mV. * indicates significantly different from control ( p < 0.05) and † indicates signficantly different from BRV (10 mM) alone group ( p < 0.05).
    Figure Legend Snippet: Mild inhibition of BRV on hyperpolarization-activated cationic current ( I h ) in GH 3 cells. The experiments were conducted in cells immersed in Ca 2+ -free Tyrode’s solution containing 1 µM tetrodotoxin, where the pipette was filled with a K + -containing solution comprising K-aspartate 130 mM, KCl 20 mM, MgCl 2 1 mM, Na 2 ATP 3 mM, Na 2 GTP 0.1 mM, EGTA 0.1 mM, and HEPES 5 mM adjusted to pH 7.2 with KOH. ( A ) Representative I h traces activated by a 2 s hyperpolarizing voltage pulse ranging from −40 to −120 mV (indicated in the upper part of the figure). (1): control, (2): 10 µM BRV, and (3): 10 µM BRV plus 3 µM cilobradine (Cil); ( B ) Summary bar graph showing the effects of BRV and BRV plus cilobradine (Cil) in hyperpolarization-activated I h (mean ± SEM; n = 8). The current amplitude was measured at the endpoint of a 2 s hyperpolarizing pulse ranging from −40 to −120 mV. * indicates significantly different from control ( p < 0.05) and † indicates signficantly different from BRV (10 mM) alone group ( p < 0.05).

    Techniques Used: Inhibition, Transferring



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    cilobradine  (MedChemExpress)
    91
    MedChemExpress cilobradine
    Mild inhibition of BRV on hyperpolarization-activated cationic current ( I h ) in GH 3 cells. The experiments were conducted in cells immersed in Ca 2+ -free Tyrode’s solution containing 1 µM tetrodotoxin, where the pipette was filled with a K + -containing solution comprising K-aspartate 130 mM, KCl 20 mM, MgCl 2 1 mM, Na 2 ATP 3 mM, Na 2 GTP 0.1 mM, EGTA 0.1 mM, and HEPES 5 mM adjusted to pH 7.2 with KOH. ( A ) Representative I h traces activated by a 2 s hyperpolarizing voltage pulse ranging from −40 to −120 mV (indicated in the upper part of the figure). (1): control, (2): 10 µM BRV, and (3): 10 µM BRV plus 3 µM <t>cilobradine</t> (Cil); ( B ) Summary bar graph showing the effects of BRV and BRV plus cilobradine (Cil) in hyperpolarization-activated I h (mean ± SEM; n = 8). The current amplitude was measured at the endpoint of a 2 s hyperpolarizing pulse ranging from −40 to −120 mV. * indicates significantly different from control ( p < 0.05) and † indicates signficantly different from BRV (10 mM) alone group ( p < 0.05).
    Cilobradine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cilobradine/product/MedChemExpress
    Average 91 stars, based on 1 article reviews
    cilobradine - by Bioz Stars, 2026-02
    91/100 stars
    		  Buy from Supplier

    Image Search Results


    Mild inhibition of BRV on hyperpolarization-activated cationic current ( I h ) in GH 3 cells. The experiments were conducted in cells immersed in Ca 2+ -free Tyrode’s solution containing 1 µM tetrodotoxin, where the pipette was filled with a K + -containing solution comprising K-aspartate 130 mM, KCl 20 mM, MgCl 2 1 mM, Na 2 ATP 3 mM, Na 2 GTP 0.1 mM, EGTA 0.1 mM, and HEPES 5 mM adjusted to pH 7.2 with KOH. ( A ) Representative I h traces activated by a 2 s hyperpolarizing voltage pulse ranging from −40 to −120 mV (indicated in the upper part of the figure). (1): control, (2): 10 µM BRV, and (3): 10 µM BRV plus 3 µM cilobradine (Cil); ( B ) Summary bar graph showing the effects of BRV and BRV plus cilobradine (Cil) in hyperpolarization-activated I h (mean ± SEM; n = 8). The current amplitude was measured at the endpoint of a 2 s hyperpolarizing pulse ranging from −40 to −120 mV. * indicates significantly different from control ( p < 0.05) and † indicates signficantly different from BRV (10 mM) alone group ( p < 0.05).

    Journal: Biomedicines

    Article Title: The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability

    doi: 10.3390/biomedicines9040369

    Figure Lengend Snippet: Mild inhibition of BRV on hyperpolarization-activated cationic current ( I h ) in GH 3 cells. The experiments were conducted in cells immersed in Ca 2+ -free Tyrode’s solution containing 1 µM tetrodotoxin, where the pipette was filled with a K + -containing solution comprising K-aspartate 130 mM, KCl 20 mM, MgCl 2 1 mM, Na 2 ATP 3 mM, Na 2 GTP 0.1 mM, EGTA 0.1 mM, and HEPES 5 mM adjusted to pH 7.2 with KOH. ( A ) Representative I h traces activated by a 2 s hyperpolarizing voltage pulse ranging from −40 to −120 mV (indicated in the upper part of the figure). (1): control, (2): 10 µM BRV, and (3): 10 µM BRV plus 3 µM cilobradine (Cil); ( B ) Summary bar graph showing the effects of BRV and BRV plus cilobradine (Cil) in hyperpolarization-activated I h (mean ± SEM; n = 8). The current amplitude was measured at the endpoint of a 2 s hyperpolarizing pulse ranging from −40 to −120 mV. * indicates significantly different from control ( p < 0.05) and † indicates signficantly different from BRV (10 mM) alone group ( p < 0.05).

    Article Snippet: GAL-021 and PF1022A were acquired from MedChemExpress (Everything Biotech, New Taipei City, Taiwan); cilobradine was obtained from Cayman (Excel Biomedical, Taipei, Taiwan); 2-chloro-α, α-diphenylbenzeneacetonitrile (TRAM39) was obtained from Tocris (Union Biomed Inc., Taipei, Taiwan), and tefluthrhin, tetraethylammonium chloride and tetrodotoxin were obtained from Sigma-Aldrich (Merck Ltd., Taipei, Taiwan).

    Techniques: Inhibition, Transferring