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oxaliplatin  (MedChemExpress)


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    MedChemExpress oxaliplatin
    Oxaliplatin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/oxaliplatin/product/MedChemExpress
    Average 96 stars, based on 28 article reviews
    oxaliplatin - by Bioz Stars, 2026-02
    96/100 stars

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    (A) At a concentration of 5 nM, TN significantly enhanced the apoptosis induced by 1.56 µM <t>OXA</t> in HCT116 and LoVo cells, as demonstrated through Annexin V/PI staining. Furthermore, HCT116 and LoVo cells that were pre-incubated with or without NAC (5 mM) for 2 h prior to co-administration of OXA and TN exhibited alterations in apoptotic activity. (B)Quantitative analysis of A. (C)The impact of NAC pre-treatment on the combination of TN with OXA treatment on colony formation. (D)Western Blot was used to assess mitochondrial apoptosis-related proteins. (E)The cells were treated with 1.56 μM OXA and/or 5 nM TN, followed by immunoblotting to assess Cleaved Caspase3 and Cleaved PARP protein.This treatment effect was notably mitigated by NAC pre-treatment. (F)HCT116 and LoVo cells were pre-incubated with different concentrations (μM) of Caspase <t>inhibitor</t> <t>Z-VAD-FMK</t> for 2 h before co-administration of TN and OXA drugs. CCK8 method was used to detect cell activity, which was repeated at least 3 times. The control group was given the same amount of DMSO. The results provided originate from three separate trials and are depicted as mean ± standard deviation. Significance levels were indicated as * P < 0.05,** P < 0.01, *** P < 0.001, and **** P < 0.0001.
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    (A) At a concentration of 5 nM, TN significantly enhanced the apoptosis induced by 1.56 µM OXA in HCT116 and LoVo cells, as demonstrated through Annexin V/PI staining. Furthermore, HCT116 and LoVo cells that were pre-incubated with or without NAC (5 mM) for 2 h prior to co-administration of OXA and TN exhibited alterations in apoptotic activity. (B)Quantitative analysis of A. (C)The impact of NAC pre-treatment on the combination of TN with OXA treatment on colony formation. (D)Western Blot was used to assess mitochondrial apoptosis-related proteins. (E)The cells were treated with 1.56 μM OXA and/or 5 nM TN, followed by immunoblotting to assess Cleaved Caspase3 and Cleaved PARP protein.This treatment effect was notably mitigated by NAC pre-treatment. (F)HCT116 and LoVo cells were pre-incubated with different concentrations (μM) of Caspase inhibitor Z-VAD-FMK for 2 h before co-administration of TN and OXA drugs. CCK8 method was used to detect cell activity, which was repeated at least 3 times. The control group was given the same amount of DMSO. The results provided originate from three separate trials and are depicted as mean ± standard deviation. Significance levels were indicated as * P < 0.05,** P < 0.01, *** P < 0.001, and **** P < 0.0001.

    Journal: Translational Oncology

    Article Title: Triptonide stabilizes BIM to enhance oxaliplatin-induced ferroptosis and apoptosis in colorectal cancer

    doi: 10.1016/j.tranon.2025.102491

    Figure Lengend Snippet: (A) At a concentration of 5 nM, TN significantly enhanced the apoptosis induced by 1.56 µM OXA in HCT116 and LoVo cells, as demonstrated through Annexin V/PI staining. Furthermore, HCT116 and LoVo cells that were pre-incubated with or without NAC (5 mM) for 2 h prior to co-administration of OXA and TN exhibited alterations in apoptotic activity. (B)Quantitative analysis of A. (C)The impact of NAC pre-treatment on the combination of TN with OXA treatment on colony formation. (D)Western Blot was used to assess mitochondrial apoptosis-related proteins. (E)The cells were treated with 1.56 μM OXA and/or 5 nM TN, followed by immunoblotting to assess Cleaved Caspase3 and Cleaved PARP protein.This treatment effect was notably mitigated by NAC pre-treatment. (F)HCT116 and LoVo cells were pre-incubated with different concentrations (μM) of Caspase inhibitor Z-VAD-FMK for 2 h before co-administration of TN and OXA drugs. CCK8 method was used to detect cell activity, which was repeated at least 3 times. The control group was given the same amount of DMSO. The results provided originate from three separate trials and are depicted as mean ± standard deviation. Significance levels were indicated as * P < 0.05,** P < 0.01, *** P < 0.001, and **** P < 0.0001.

    Article Snippet: OXA (CAS No 61825-94-3) and Z-VAD-FMK (CAS NO.161401-82-7) were acquired from MedChemexpress (MCE) Biotechnology, New Jersey, USA.

    Techniques: Concentration Assay, Staining, Incubation, Activity Assay, Western Blot, Control, Standard Deviation