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tazarotene  (MedChemExpress)


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    Structured Review

    MedChemExpress tazarotene
    Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), <t>tazarotene,</t> or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.
    Tazarotene, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tazarotene/product/MedChemExpress
    Average 91 stars, based on 3 article reviews
    tazarotene - by Bioz Stars, 2026-02
    91/100 stars

    Images

    1) Product Images from "Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RAR γ ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation"

    Article Title: Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RAR γ ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation

    Journal: Advanced Science

    doi: 10.1002/advs.202203173

    Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), tazarotene, or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.
    Figure Legend Snippet: Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), tazarotene, or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.

    Techniques Used: MTT Assay, Flow Cytometry, Western Blot, Expressing



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    tazarotene  (MedChemExpress)
    91
    MedChemExpress tazarotene
    Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), <t>tazarotene,</t> or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.
    Tazarotene, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tazarotene/product/MedChemExpress
    Average 91 stars, based on 1 article reviews
    tazarotene - by Bioz Stars, 2026-02
    91/100 stars
    		  Buy from Supplier

    Image Search Results


    Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), tazarotene, or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.

    Journal: Advanced Science

    Article Title: Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RAR γ ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation

    doi: 10.1002/advs.202203173

    Figure Lengend Snippet: Retinoid WYC‐209 is highly potent in inducing tumor cell apoptosis. A) The IC 50 values of conventional drugs (all‐trans retinoic acid (ATRA), tazarotene, or cisplatin) or WYC‐209 for B16‐F1 TRCs were determined in the MTT assay after treatment for 48 h. B,C) B16 TRCs were treated with ATRA, tazarotene, cisplatin at 10 and 100 µ m and WYC‐209 at 10 µ m for 24 h, then the cell apoptotic ratio analyzed by FITC–Annexin‐V and PI apoptosis detection kit. Representative images of flow cytometry data (B) and quantification data of apoptotic cells ratio (C). Apoptotic cells (%) = 100% − (Annexin‐V − PI − )%. D–K) Representative western blot images (D, F, H, J) and quantification (E, G, I, K) of relative γ H2AX, C‐PARP, and C‐Caspase3 expression of B16 TRCs treated with 100 µ m ATRA, 100 µ m tazarotene, 100 µ m cisplatin, or 10 µ m WYC‐209 for various durations. Mean ± s.e.m.; three independent experiments. One‐way ANOVA testing followed by a Tukey post‐hoc test when appropriate was used for statistics. * p < 0.05; ** p < 0.01; *** p < 0.001; ns = not significantly different.

    Article Snippet: Cisplatin (HY‐17394), tazarotene (HY‐15388), and ATRA (HY‐14649) were obtained from MedChem Express (NJ, USA).

    Techniques: MTT Assay, Flow Cytometry, Western Blot, Expressing