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bexarotene  (MedChemExpress)


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    MedChemExpress bexarotene
    RA–RARα signaling induces CIITA‐dependent antigen‐presenting programming in mast cells. A) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +TTNPB and IFN‐γ <t>+Bexarotene</t> treatment for 48 h ( n = 3). B) Flow cytometry analysis showing CD40 expression after IFN‐γ +TTNPB and IFN‐γ +Bexarotene treatment for 48 h ( n = 3). C) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +AM580, IFN‐γ +Adapalene, and IFN‐γ +Palovarotene treatment for 48 h ( n = 3). D) Flow cytometry analysis showing CD40 expression after IFN‐γ +AM580, IFN‐γ +Adapalene, and IFN‐γ +Palovarotene treatment for 48 h ( n = 3). E) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3). F) Flow cytometry analysis showing CD40 expression after IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3). G) Flow cytometry analysis showing CMV antigen presentation by mast cells to CD4⁺ and CD8⁺ T cells under different treatments, with T cell activation assessed by 4‐1BB and TNF‐α expression. H) Volcano plot showing significantly differentially expressed genes between the IFN‐γ + RA treatment group and the IFN‐γ treatment alone group. I) The mRNA expression of CIITA after IFN‐γ, RA, IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3).
    Bexarotene, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 35 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bexarotene/product/MedChemExpress
    Average 94 stars, based on 35 article reviews
    bexarotene - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity"

    Article Title: Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

    Journal: Advanced Science

    doi: 10.1002/advs.202509340

    RA–RARα signaling induces CIITA‐dependent antigen‐presenting programming in mast cells. A) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +TTNPB and IFN‐γ +Bexarotene treatment for 48 h ( n = 3). B) Flow cytometry analysis showing CD40 expression after IFN‐γ +TTNPB and IFN‐γ +Bexarotene treatment for 48 h ( n = 3). C) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +AM580, IFN‐γ +Adapalene, and IFN‐γ +Palovarotene treatment for 48 h ( n = 3). D) Flow cytometry analysis showing CD40 expression after IFN‐γ +AM580, IFN‐γ +Adapalene, and IFN‐γ +Palovarotene treatment for 48 h ( n = 3). E) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3). F) Flow cytometry analysis showing CD40 expression after IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3). G) Flow cytometry analysis showing CMV antigen presentation by mast cells to CD4⁺ and CD8⁺ T cells under different treatments, with T cell activation assessed by 4‐1BB and TNF‐α expression. H) Volcano plot showing significantly differentially expressed genes between the IFN‐γ + RA treatment group and the IFN‐γ treatment alone group. I) The mRNA expression of CIITA after IFN‐γ, RA, IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3).
    Figure Legend Snippet: RA–RARα signaling induces CIITA‐dependent antigen‐presenting programming in mast cells. A) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +TTNPB and IFN‐γ +Bexarotene treatment for 48 h ( n = 3). B) Flow cytometry analysis showing CD40 expression after IFN‐γ +TTNPB and IFN‐γ +Bexarotene treatment for 48 h ( n = 3). C) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +AM580, IFN‐γ +Adapalene, and IFN‐γ +Palovarotene treatment for 48 h ( n = 3). D) Flow cytometry analysis showing CD40 expression after IFN‐γ +AM580, IFN‐γ +Adapalene, and IFN‐γ +Palovarotene treatment for 48 h ( n = 3). E) Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3). F) Flow cytometry analysis showing CD40 expression after IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3). G) Flow cytometry analysis showing CMV antigen presentation by mast cells to CD4⁺ and CD8⁺ T cells under different treatments, with T cell activation assessed by 4‐1BB and TNF‐α expression. H) Volcano plot showing significantly differentially expressed genes between the IFN‐γ + RA treatment group and the IFN‐γ treatment alone group. I) The mRNA expression of CIITA after IFN‐γ, RA, IFN‐γ +RA, IFN‐γ + RA+ Ro 41‐5253 treatment for 48 h ( n = 3).

    Techniques Used: Flow Cytometry, Expressing, Immunopeptidomics, Activation Assay



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