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tecovirimat st 246  (MedChemExpress)


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    Structured Review

    MedChemExpress tecovirimat st 246
    JCS-2022 inhibits VACV EEV formation by targeting F13. A) Chemical structure of JCS-2022 and the molecular docking information of JCS-2022 with F13. B) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within MPXV F13 protein. Different colors in F13 represent various 2D structures: red signifies α-helices, yellow indicates β-folds, and blue denotes β-turns. Amino acids within a 4.5 Å distance around JCS2022 are labeled with their names and positions. Light blue dashed lines represent interactions between molecules, with a maximum energy cutoff of −0.5 kcal/mol. C) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VARV F13 protein. D) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VACV F13 protein. E) HeLa cells were treated with an increased dosage of JCS-2022 for 24 h and then the cell viability was measured by CCK8 assay. ns, no significance. F) Inhibition of EEV by JCS-2022 and <t>ST-246.</t> HeLa cells were infected with VACV WR at a MOI of 3 for 2 h and then added increased dosages of JCS-2022 or ST-246 for another 22 h. The EEV was collected and titrated by BSC-1 cells. G) The effect of JCS-2022 with different dosages on VACV plaque size. BSC-1 cells in 12-well plates were infected with VAVC WR for 2 h and then treated with indicated dosages of JCS-2022 for 3 d. The cells were stained with crystal violet. *, P value < 0.05. H) JCS-2022 reduced the formation of the actin tail. HeLa cells were transfected with the plasmid expressing HA-tagged MPXV F13 for 24 h and then infected with VACV WR (MOI = 3) in the presence of 1.6 μM JCS-2022 or mock for another 24 h. The cells were stained with antibodies against HA (green). Actin tails were stained by Rhodamine-labeled phalloidin (red). Scale bar: 10 μM. Abbreviations: μM, μmol/L; VACV, vaccinia virus; EEV, extracellular enveloped virus; MPXV, mpox virus; VARV, variola virus; CCK8, Cell Counting Kit 8; WR, Western Reserve; MOI, multiplicity of infection; BSC-1, biologics standards-Cercopithecus-1; HA, hemagglutinin; EC 50 , half maximal effective concentration.
    Tecovirimat St 246, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 2 article reviews
    tecovirimat st 246 - by Bioz Stars, 2026-02
    93/100 stars

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    1) Product Images from "AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13"

    Article Title: AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13

    Journal: Biosafety and Health

    doi: 10.1016/j.bsheal.2024.12.002

    JCS-2022 inhibits VACV EEV formation by targeting F13. A) Chemical structure of JCS-2022 and the molecular docking information of JCS-2022 with F13. B) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within MPXV F13 protein. Different colors in F13 represent various 2D structures: red signifies α-helices, yellow indicates β-folds, and blue denotes β-turns. Amino acids within a 4.5 Å distance around JCS2022 are labeled with their names and positions. Light blue dashed lines represent interactions between molecules, with a maximum energy cutoff of −0.5 kcal/mol. C) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VARV F13 protein. D) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VACV F13 protein. E) HeLa cells were treated with an increased dosage of JCS-2022 for 24 h and then the cell viability was measured by CCK8 assay. ns, no significance. F) Inhibition of EEV by JCS-2022 and ST-246. HeLa cells were infected with VACV WR at a MOI of 3 for 2 h and then added increased dosages of JCS-2022 or ST-246 for another 22 h. The EEV was collected and titrated by BSC-1 cells. G) The effect of JCS-2022 with different dosages on VACV plaque size. BSC-1 cells in 12-well plates were infected with VAVC WR for 2 h and then treated with indicated dosages of JCS-2022 for 3 d. The cells were stained with crystal violet. *, P value < 0.05. H) JCS-2022 reduced the formation of the actin tail. HeLa cells were transfected with the plasmid expressing HA-tagged MPXV F13 for 24 h and then infected with VACV WR (MOI = 3) in the presence of 1.6 μM JCS-2022 or mock for another 24 h. The cells were stained with antibodies against HA (green). Actin tails were stained by Rhodamine-labeled phalloidin (red). Scale bar: 10 μM. Abbreviations: μM, μmol/L; VACV, vaccinia virus; EEV, extracellular enveloped virus; MPXV, mpox virus; VARV, variola virus; CCK8, Cell Counting Kit 8; WR, Western Reserve; MOI, multiplicity of infection; BSC-1, biologics standards-Cercopithecus-1; HA, hemagglutinin; EC 50 , half maximal effective concentration.
    Figure Legend Snippet: JCS-2022 inhibits VACV EEV formation by targeting F13. A) Chemical structure of JCS-2022 and the molecular docking information of JCS-2022 with F13. B) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within MPXV F13 protein. Different colors in F13 represent various 2D structures: red signifies α-helices, yellow indicates β-folds, and blue denotes β-turns. Amino acids within a 4.5 Å distance around JCS2022 are labeled with their names and positions. Light blue dashed lines represent interactions between molecules, with a maximum energy cutoff of −0.5 kcal/mol. C) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VARV F13 protein. D) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VACV F13 protein. E) HeLa cells were treated with an increased dosage of JCS-2022 for 24 h and then the cell viability was measured by CCK8 assay. ns, no significance. F) Inhibition of EEV by JCS-2022 and ST-246. HeLa cells were infected with VACV WR at a MOI of 3 for 2 h and then added increased dosages of JCS-2022 or ST-246 for another 22 h. The EEV was collected and titrated by BSC-1 cells. G) The effect of JCS-2022 with different dosages on VACV plaque size. BSC-1 cells in 12-well plates were infected with VAVC WR for 2 h and then treated with indicated dosages of JCS-2022 for 3 d. The cells were stained with crystal violet. *, P value < 0.05. H) JCS-2022 reduced the formation of the actin tail. HeLa cells were transfected with the plasmid expressing HA-tagged MPXV F13 for 24 h and then infected with VACV WR (MOI = 3) in the presence of 1.6 μM JCS-2022 or mock for another 24 h. The cells were stained with antibodies against HA (green). Actin tails were stained by Rhodamine-labeled phalloidin (red). Scale bar: 10 μM. Abbreviations: μM, μmol/L; VACV, vaccinia virus; EEV, extracellular enveloped virus; MPXV, mpox virus; VARV, variola virus; CCK8, Cell Counting Kit 8; WR, Western Reserve; MOI, multiplicity of infection; BSC-1, biologics standards-Cercopithecus-1; HA, hemagglutinin; EC 50 , half maximal effective concentration.

    Techniques Used: Labeling, CCK-8 Assay, Inhibition, Infection, Staining, Transfection, Plasmid Preparation, Expressing, Virus, Cell Counting, Western Blot, Concentration Assay



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    JCS-2022 inhibits VACV EEV formation by targeting F13. A) Chemical structure of JCS-2022 and the molecular docking information of JCS-2022 with F13. B) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within MPXV F13 protein. Different colors in F13 represent various 2D structures: red signifies α-helices, yellow indicates β-folds, and blue denotes β-turns. Amino acids within a 4.5 Å distance around JCS2022 are labeled with their names and positions. Light blue dashed lines represent interactions between molecules, with a maximum energy cutoff of −0.5 kcal/mol. C) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VARV F13 protein. D) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VACV F13 protein. E) HeLa cells were treated with an increased dosage of JCS-2022 for 24 h and then the cell viability was measured by CCK8 assay. ns, no significance. F) Inhibition of EEV by JCS-2022 and <t>ST-246.</t> HeLa cells were infected with VACV WR at a MOI of 3 for 2 h and then added increased dosages of JCS-2022 or ST-246 for another 22 h. The EEV was collected and titrated by BSC-1 cells. G) The effect of JCS-2022 with different dosages on VACV plaque size. BSC-1 cells in 12-well plates were infected with VAVC WR for 2 h and then treated with indicated dosages of JCS-2022 for 3 d. The cells were stained with crystal violet. *, P value < 0.05. H) JCS-2022 reduced the formation of the actin tail. HeLa cells were transfected with the plasmid expressing HA-tagged MPXV F13 for 24 h and then infected with VACV WR (MOI = 3) in the presence of 1.6 μM JCS-2022 or mock for another 24 h. The cells were stained with antibodies against HA (green). Actin tails were stained by Rhodamine-labeled phalloidin (red). Scale bar: 10 μM. Abbreviations: μM, μmol/L; VACV, vaccinia virus; EEV, extracellular enveloped virus; MPXV, mpox virus; VARV, variola virus; CCK8, Cell Counting Kit 8; WR, Western Reserve; MOI, multiplicity of infection; BSC-1, biologics standards-Cercopithecus-1; HA, hemagglutinin; EC 50 , half maximal effective concentration.
    Tecovirimat St 246, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tecovirimat st 246/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    tecovirimat st 246 - by Bioz Stars, 2026-02
    93/100 stars
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    drug inhibition assay  (MedChemExpress)
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    JCS-2022 inhibits VACV EEV formation by targeting F13. A) Chemical structure of JCS-2022 and the molecular docking information of JCS-2022 with F13. B) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within MPXV F13 protein. Different colors in F13 represent various 2D structures: red signifies α-helices, yellow indicates β-folds, and blue denotes β-turns. Amino acids within a 4.5 Å distance around JCS2022 are labeled with their names and positions. Light blue dashed lines represent interactions between molecules, with a maximum energy cutoff of −0.5 kcal/mol. C) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VARV F13 protein. D) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VACV F13 protein. E) HeLa cells were treated with an increased dosage of JCS-2022 for 24 h and then the cell viability was measured by CCK8 assay. ns, no significance. F) Inhibition of EEV by JCS-2022 and <t>ST-246.</t> HeLa cells were infected with VACV WR at a MOI of 3 for 2 h and then added increased dosages of JCS-2022 or ST-246 for another 22 h. The EEV was collected and titrated by BSC-1 cells. G) The effect of JCS-2022 with different dosages on VACV plaque size. BSC-1 cells in 12-well plates were infected with VAVC WR for 2 h and then treated with indicated dosages of JCS-2022 for 3 d. The cells were stained with crystal violet. *, P value < 0.05. H) JCS-2022 reduced the formation of the actin tail. HeLa cells were transfected with the plasmid expressing HA-tagged MPXV F13 for 24 h and then infected with VACV WR (MOI = 3) in the presence of 1.6 μM JCS-2022 or mock for another 24 h. The cells were stained with antibodies against HA (green). Actin tails were stained by Rhodamine-labeled phalloidin (red). Scale bar: 10 μM. Abbreviations: μM, μmol/L; VACV, vaccinia virus; EEV, extracellular enveloped virus; MPXV, mpox virus; VARV, variola virus; CCK8, Cell Counting Kit 8; WR, Western Reserve; MOI, multiplicity of infection; BSC-1, biologics standards-Cercopithecus-1; HA, hemagglutinin; EC 50 , half maximal effective concentration.
    Drug Inhibition Assay, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/drug inhibition assay/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    drug inhibition assay - by Bioz Stars, 2026-02
    93/100 stars
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    JCS-2022 inhibits VACV EEV formation by targeting F13. A) Chemical structure of JCS-2022 and the molecular docking information of JCS-2022 with F13. B) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within MPXV F13 protein. Different colors in F13 represent various 2D structures: red signifies α-helices, yellow indicates β-folds, and blue denotes β-turns. Amino acids within a 4.5 Å distance around JCS2022 are labeled with their names and positions. Light blue dashed lines represent interactions between molecules, with a maximum energy cutoff of −0.5 kcal/mol. C) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VARV F13 protein. D) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VACV F13 protein. E) HeLa cells were treated with an increased dosage of JCS-2022 for 24 h and then the cell viability was measured by CCK8 assay. ns, no significance. F) Inhibition of EEV by JCS-2022 and ST-246. HeLa cells were infected with VACV WR at a MOI of 3 for 2 h and then added increased dosages of JCS-2022 or ST-246 for another 22 h. The EEV was collected and titrated by BSC-1 cells. G) The effect of JCS-2022 with different dosages on VACV plaque size. BSC-1 cells in 12-well plates were infected with VAVC WR for 2 h and then treated with indicated dosages of JCS-2022 for 3 d. The cells were stained with crystal violet. *, P value < 0.05. H) JCS-2022 reduced the formation of the actin tail. HeLa cells were transfected with the plasmid expressing HA-tagged MPXV F13 for 24 h and then infected with VACV WR (MOI = 3) in the presence of 1.6 μM JCS-2022 or mock for another 24 h. The cells were stained with antibodies against HA (green). Actin tails were stained by Rhodamine-labeled phalloidin (red). Scale bar: 10 μM. Abbreviations: μM, μmol/L; VACV, vaccinia virus; EEV, extracellular enveloped virus; MPXV, mpox virus; VARV, variola virus; CCK8, Cell Counting Kit 8; WR, Western Reserve; MOI, multiplicity of infection; BSC-1, biologics standards-Cercopithecus-1; HA, hemagglutinin; EC 50 , half maximal effective concentration.

    Journal: Biosafety and Health

    Article Title: AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13

    doi: 10.1016/j.bsheal.2024.12.002

    Figure Lengend Snippet: JCS-2022 inhibits VACV EEV formation by targeting F13. A) Chemical structure of JCS-2022 and the molecular docking information of JCS-2022 with F13. B) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within MPXV F13 protein. Different colors in F13 represent various 2D structures: red signifies α-helices, yellow indicates β-folds, and blue denotes β-turns. Amino acids within a 4.5 Å distance around JCS2022 are labeled with their names and positions. Light blue dashed lines represent interactions between molecules, with a maximum energy cutoff of −0.5 kcal/mol. C) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VARV F13 protein. D) The poses with the minimum free energy of JCS-2022 along with its corresponding interactions plots within VACV F13 protein. E) HeLa cells were treated with an increased dosage of JCS-2022 for 24 h and then the cell viability was measured by CCK8 assay. ns, no significance. F) Inhibition of EEV by JCS-2022 and ST-246. HeLa cells were infected with VACV WR at a MOI of 3 for 2 h and then added increased dosages of JCS-2022 or ST-246 for another 22 h. The EEV was collected and titrated by BSC-1 cells. G) The effect of JCS-2022 with different dosages on VACV plaque size. BSC-1 cells in 12-well plates were infected with VAVC WR for 2 h and then treated with indicated dosages of JCS-2022 for 3 d. The cells were stained with crystal violet. *, P value < 0.05. H) JCS-2022 reduced the formation of the actin tail. HeLa cells were transfected with the plasmid expressing HA-tagged MPXV F13 for 24 h and then infected with VACV WR (MOI = 3) in the presence of 1.6 μM JCS-2022 or mock for another 24 h. The cells were stained with antibodies against HA (green). Actin tails were stained by Rhodamine-labeled phalloidin (red). Scale bar: 10 μM. Abbreviations: μM, μmol/L; VACV, vaccinia virus; EEV, extracellular enveloped virus; MPXV, mpox virus; VARV, variola virus; CCK8, Cell Counting Kit 8; WR, Western Reserve; MOI, multiplicity of infection; BSC-1, biologics standards-Cercopithecus-1; HA, hemagglutinin; EC 50 , half maximal effective concentration.

    Article Snippet: Tecovirimat (ST-246) is from MedChemExpress. dimethylsulfoxide (DMSO) (Solarbio, D8371, China) was used to prepare the stock solutions of JCS-2022 and ST-246.

    Techniques: Labeling, CCK-8 Assay, Inhibition, Infection, Staining, Transfection, Plasmid Preparation, Expressing, Virus, Cell Counting, Western Blot, Concentration Assay