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ag 636  (MedChemExpress)


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    MedChemExpress ag 636
    A-E) Dose-response curves of DHODH inhibitors GTX-196 (panel A ), BAY-2402234 (panel B ), PTC299 (panel C) <t>,</t> <t>AG-636</t> (panel D) , and Farudodstat (ASLAN003; panel E) for the indicated normal kidney organoid and ecMRT tumoroid cultures. Data points are represented as the mean ± SD of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). F) Scatterplots showing the individual IC 50 of each ecMRT tumoroid model, grouped per DHODH inhibitor. Mean ± SD are also plotted. G) Dose-response curves of BAY-2402234 for the indicated normal kidney organoid and AT/RT and SCCOHT tumoroid cultures. Data points are represented as the mean ± SD of three independent experiments, each consisting of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). H) Bar graphs representing live (yellow), early apoptotic (orange), and late apoptotic (purple) cell fractions of AT/RT-SHH, AT/RT-MYC and SCCOHT tumoroids upon treatment with 50 nM GTX-196 or DMSO vehicle control for 120 h. The means ± SD of n = 2 models are plotted. (*, p < 0.05).
    Ag 636, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ag 636/product/MedChemExpress
    Average 94 stars, based on 3 article reviews
    ag 636 - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "hENT Inhibition Prevents Pyrimidine-Driven Resistance to DHODH Inhibition in Malignant Rhabdoid Tumors"

    Article Title: hENT Inhibition Prevents Pyrimidine-Driven Resistance to DHODH Inhibition in Malignant Rhabdoid Tumors

    Journal: bioRxiv

    doi: 10.64898/2026.01.25.701565

    A-E) Dose-response curves of DHODH inhibitors GTX-196 (panel A ), BAY-2402234 (panel B ), PTC299 (panel C) , AG-636 (panel D) , and Farudodstat (ASLAN003; panel E) for the indicated normal kidney organoid and ecMRT tumoroid cultures. Data points are represented as the mean ± SD of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). F) Scatterplots showing the individual IC 50 of each ecMRT tumoroid model, grouped per DHODH inhibitor. Mean ± SD are also plotted. G) Dose-response curves of BAY-2402234 for the indicated normal kidney organoid and AT/RT and SCCOHT tumoroid cultures. Data points are represented as the mean ± SD of three independent experiments, each consisting of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). H) Bar graphs representing live (yellow), early apoptotic (orange), and late apoptotic (purple) cell fractions of AT/RT-SHH, AT/RT-MYC and SCCOHT tumoroids upon treatment with 50 nM GTX-196 or DMSO vehicle control for 120 h. The means ± SD of n = 2 models are plotted. (*, p < 0.05).
    Figure Legend Snippet: A-E) Dose-response curves of DHODH inhibitors GTX-196 (panel A ), BAY-2402234 (panel B ), PTC299 (panel C) , AG-636 (panel D) , and Farudodstat (ASLAN003; panel E) for the indicated normal kidney organoid and ecMRT tumoroid cultures. Data points are represented as the mean ± SD of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). F) Scatterplots showing the individual IC 50 of each ecMRT tumoroid model, grouped per DHODH inhibitor. Mean ± SD are also plotted. G) Dose-response curves of BAY-2402234 for the indicated normal kidney organoid and AT/RT and SCCOHT tumoroid cultures. Data points are represented as the mean ± SD of three independent experiments, each consisting of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). H) Bar graphs representing live (yellow), early apoptotic (orange), and late apoptotic (purple) cell fractions of AT/RT-SHH, AT/RT-MYC and SCCOHT tumoroids upon treatment with 50 nM GTX-196 or DMSO vehicle control for 120 h. The means ± SD of n = 2 models are plotted. (*, p < 0.05).

    Techniques Used: Control



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    A-E) Dose-response curves of DHODH inhibitors GTX-196 (panel A ), BAY-2402234 (panel B ), PTC299 (panel C) <t>,</t> <t>AG-636</t> (panel D) , and Farudodstat (ASLAN003; panel E) for the indicated normal kidney organoid and ecMRT tumoroid cultures. Data points are represented as the mean ± SD of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). F) Scatterplots showing the individual IC 50 of each ecMRT tumoroid model, grouped per DHODH inhibitor. Mean ± SD are also plotted. G) Dose-response curves of BAY-2402234 for the indicated normal kidney organoid and AT/RT and SCCOHT tumoroid cultures. Data points are represented as the mean ± SD of three independent experiments, each consisting of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). H) Bar graphs representing live (yellow), early apoptotic (orange), and late apoptotic (purple) cell fractions of AT/RT-SHH, AT/RT-MYC and SCCOHT tumoroids upon treatment with 50 nM GTX-196 or DMSO vehicle control for 120 h. The means ± SD of n = 2 models are plotted. (*, p < 0.05).
    Ag 636, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    A-E) Dose-response curves of DHODH inhibitors GTX-196 (panel A ), BAY-2402234 (panel B ), PTC299 (panel C) <t>,</t> <t>AG-636</t> (panel D) , and Farudodstat (ASLAN003; panel E) for the indicated normal kidney organoid and ecMRT tumoroid cultures. Data points are represented as the mean ± SD of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). F) Scatterplots showing the individual IC 50 of each ecMRT tumoroid model, grouped per DHODH inhibitor. Mean ± SD are also plotted. G) Dose-response curves of BAY-2402234 for the indicated normal kidney organoid and AT/RT and SCCOHT tumoroid cultures. Data points are represented as the mean ± SD of three independent experiments, each consisting of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). H) Bar graphs representing live (yellow), early apoptotic (orange), and late apoptotic (purple) cell fractions of AT/RT-SHH, AT/RT-MYC and SCCOHT tumoroids upon treatment with 50 nM GTX-196 or DMSO vehicle control for 120 h. The means ± SD of n = 2 models are plotted. (*, p < 0.05).
    Teriflunomide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    A-E) Dose-response curves of DHODH inhibitors GTX-196 (panel A ), BAY-2402234 (panel B ), PTC299 (panel C) , AG-636 (panel D) , and Farudodstat (ASLAN003; panel E) for the indicated normal kidney organoid and ecMRT tumoroid cultures. Data points are represented as the mean ± SD of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). F) Scatterplots showing the individual IC 50 of each ecMRT tumoroid model, grouped per DHODH inhibitor. Mean ± SD are also plotted. G) Dose-response curves of BAY-2402234 for the indicated normal kidney organoid and AT/RT and SCCOHT tumoroid cultures. Data points are represented as the mean ± SD of three independent experiments, each consisting of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). H) Bar graphs representing live (yellow), early apoptotic (orange), and late apoptotic (purple) cell fractions of AT/RT-SHH, AT/RT-MYC and SCCOHT tumoroids upon treatment with 50 nM GTX-196 or DMSO vehicle control for 120 h. The means ± SD of n = 2 models are plotted. (*, p < 0.05).

    Journal: bioRxiv

    Article Title: hENT Inhibition Prevents Pyrimidine-Driven Resistance to DHODH Inhibition in Malignant Rhabdoid Tumors

    doi: 10.64898/2026.01.25.701565

    Figure Lengend Snippet: A-E) Dose-response curves of DHODH inhibitors GTX-196 (panel A ), BAY-2402234 (panel B ), PTC299 (panel C) , AG-636 (panel D) , and Farudodstat (ASLAN003; panel E) for the indicated normal kidney organoid and ecMRT tumoroid cultures. Data points are represented as the mean ± SD of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). F) Scatterplots showing the individual IC 50 of each ecMRT tumoroid model, grouped per DHODH inhibitor. Mean ± SD are also plotted. G) Dose-response curves of BAY-2402234 for the indicated normal kidney organoid and AT/RT and SCCOHT tumoroid cultures. Data points are represented as the mean ± SD of three independent experiments, each consisting of quadruplicate measurements. Data are normalized to DMSO vehicle (100%). The grey dotted horizontal line represents a viability of 50% (IC 50 ). H) Bar graphs representing live (yellow), early apoptotic (orange), and late apoptotic (purple) cell fractions of AT/RT-SHH, AT/RT-MYC and SCCOHT tumoroids upon treatment with 50 nM GTX-196 or DMSO vehicle control for 120 h. The means ± SD of n = 2 models are plotted. (*, p < 0.05).

    Article Snippet: BAY-2402234 (MedChemExpress, HY-112645), GTX-196 (Genase Therapeutics), AG-636 (MedChemExpress, HY-137463), ASLAN003/Farudodstat (MedChemExpress, HY-129239), PTC299 (MedChemExpress, HY-124593), Dipyridamole (MedChemExpress, HY-B0312), Nitrobenzylthioinosine (NBMPR; MedChemExpress, HY-W010936), and Draflazine (MedChemExpress, HY-106841) were tested at final concentrations ranging between 0.01 nM and 10 μM.

    Techniques: Control