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vanoxerine dihydrochloride  (MedChemExpress)


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    MedChemExpress vanoxerine dihydrochloride
    Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. <t>Vanoxerine</t> <t>dihydrochloride</t> and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.
    Vanoxerine Dihydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vanoxerine dihydrochloride/product/MedChemExpress
    Average 93 stars, based on 6 article reviews
    vanoxerine dihydrochloride - by Bioz Stars, 2026-02
    93/100 stars

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    1) Product Images from "Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor"

    Article Title: Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2024.1422693

    Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. Vanoxerine dihydrochloride and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.
    Figure Legend Snippet: Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. Vanoxerine dihydrochloride and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.

    Techniques Used: Inhibition, Saline, Western Blot



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    Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. <t>Vanoxerine</t> <t>dihydrochloride</t> and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.
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    Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. <t>Vanoxerine</t> <t>dihydrochloride</t> and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.
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    Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. <t>Vanoxerine</t> <t>dihydrochloride</t> and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.
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    Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. <t>Vanoxerine</t> <t>dihydrochloride</t> and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.
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    Image Search Results


    Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. Vanoxerine dihydrochloride and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.

    Journal: Frontiers in Pharmacology

    Article Title: Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor

    doi: 10.3389/fphar.2024.1422693

    Figure Lengend Snippet: Pharmacological inhibition of the 5-HT2C receptor reversed the impairment of cued fear learning and memory in Bmal1 +/− mice. (A) Schematic representation of the experimental timeline. Vanoxerine dihydrochloride and SB242084 were administrated 20 min before cued fear conditioning. (B, C) Freezing levels of Bmal1 +/− mice in cued fear conditioning and the recall test. Saline + Bmal1 +/− group, n = 7 mice; VD + Bmal1 +/− group, n = 7 mice; SB242084 + Bmal1 +/− group, n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084+ Bmal1 +/− group. ns, no significance; * p < 0.05; ** p < 0.01. (D, E) Representative Western blot images (D) and protein levels of DAT, TH, and TPH2 in the PFC of Bmal1 +/− mice after the cued fear conditioning paradigm (E) . n = 7 mice. Data are reported as mean ± SEM. Unpaired t-test. Saline + Bmal1 +/− group vs. VD + Bmal1 +/− group; saline + Bmal1 +/− group vs. SB242084 + Bmal1 +/− group. ns, no significance; *p < 0.05.

    Article Snippet: Experiment 2: to further confirm the functional role of 5-HT and dopamine in cued fear learning and memory, vanoxerine dihydrochloride (VD, a selective dopamine uptake inhibitor, HY-13217, MedChemExpress, NJ, United States, 20 mg/kg dissolved in saline) or SB242084 (selective 5-HT2C receptor antagonist, HY-13409, MedChemExpress, NJ, United States, 1 mg/kg dissolved in saline) was, respectively, injected intraperitoneally 20 min before cued fear conditioning.

    Techniques: Inhibition, Saline, Western Blot