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idh1 inhibitor 2  (MedChemExpress)


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    MedChemExpress idh1 inhibitor 2
    Idh1 Inhibitor 2, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/idh1 inhibitor 2/product/MedChemExpress
    Average 93 stars, based on 4 article reviews
    idh1 inhibitor 2 - by Bioz Stars, 2026-02
    93/100 stars

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    idh1 inhibitor 2  (MedChemExpress)
    93
    MedChemExpress idh1 inhibitor 2
    Idh1 Inhibitor 2, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/idh1 inhibitor 2/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    idh1 inhibitor 2 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier
    idh1 inhibitors  (MedChemExpress)
    93
    MedChemExpress idh1 inhibitors
    Molecular docking of <t>IDH1</t> with SKP2. A RMSD curve of the complex, Rg curve, RMSF curve of the protein, SASA curve of the complex, and hydrogen bond change curve of the complex. B Gibbs free energy topography of the complex. IDH1 protein expression after 2 h, 4 h and 8 h of MG132 and untreated HepG2 cells treated with CHX, respectively. Co-IP assay was used to verify that SKP2 ubiquitinated IDH1 in hepatoblastoma cell lines. SKP2 ubiquitylation modifies IDH1 and then degradation of the ubiquitinated IDH1 protein by the proteasome
    Idh1 Inhibitors, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/idh1 inhibitors/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    idh1 inhibitors - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

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    Molecular docking of IDH1 with SKP2. A RMSD curve of the complex, Rg curve, RMSF curve of the protein, SASA curve of the complex, and hydrogen bond change curve of the complex. B Gibbs free energy topography of the complex. IDH1 protein expression after 2 h, 4 h and 8 h of MG132 and untreated HepG2 cells treated with CHX, respectively. Co-IP assay was used to verify that SKP2 ubiquitinated IDH1 in hepatoblastoma cell lines. SKP2 ubiquitylation modifies IDH1 and then degradation of the ubiquitinated IDH1 protein by the proteasome

    Journal: BMC Cancer

    Article Title: SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism

    doi: 10.1186/s12885-025-14644-5

    Figure Lengend Snippet: Molecular docking of IDH1 with SKP2. A RMSD curve of the complex, Rg curve, RMSF curve of the protein, SASA curve of the complex, and hydrogen bond change curve of the complex. B Gibbs free energy topography of the complex. IDH1 protein expression after 2 h, 4 h and 8 h of MG132 and untreated HepG2 cells treated with CHX, respectively. Co-IP assay was used to verify that SKP2 ubiquitinated IDH1 in hepatoblastoma cell lines. SKP2 ubiquitylation modifies IDH1 and then degradation of the ubiquitinated IDH1 protein by the proteasome

    Article Snippet: To treat the cells, we used SKP2 inhibitors(Selleck, S8652, 10mM (1mL in DMSO), China) as well as IDH1 inhibitors (MedchemExpress, HY-128661, 10mM (1mL in DMSO), USA)to treat the cells.

    Techniques: Expressing, Co-Immunoprecipitation Assay

    Moderate IDH1 inhibitors can lead to the growth of hepatoblastoma. A CCK-8 was used to detect the effect of different concentrations on cell proliferation and the proliferation ability of HepG2 cells in 0.4µM IDH1 inhibitor and non-treatment groups within 48 h. B Western blotting was used to analyze the effect of IDH1 inhibitor. C HepG2 cells after different treatments. D Transwell assay was used to detect the migration and invasion ability of cells. E Cell migration ability was detected by Wound-healing assay. Ability of cells to form colonies after 14 days of inhibitor treatment. F Histogram of glucose metabolism in cells treated with IDH1 inhibitor. Statistical differences are indicated as follows: * p < 0.05, * * p < 0.01, * * * p < 0.001, * * * * p < 0.0001

    Journal: BMC Cancer

    Article Title: SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism

    doi: 10.1186/s12885-025-14644-5

    Figure Lengend Snippet: Moderate IDH1 inhibitors can lead to the growth of hepatoblastoma. A CCK-8 was used to detect the effect of different concentrations on cell proliferation and the proliferation ability of HepG2 cells in 0.4µM IDH1 inhibitor and non-treatment groups within 48 h. B Western blotting was used to analyze the effect of IDH1 inhibitor. C HepG2 cells after different treatments. D Transwell assay was used to detect the migration and invasion ability of cells. E Cell migration ability was detected by Wound-healing assay. Ability of cells to form colonies after 14 days of inhibitor treatment. F Histogram of glucose metabolism in cells treated with IDH1 inhibitor. Statistical differences are indicated as follows: * p < 0.05, * * p < 0.01, * * * p < 0.001, * * * * p < 0.0001

    Article Snippet: To treat the cells, we used SKP2 inhibitors(Selleck, S8652, 10mM (1mL in DMSO), China) as well as IDH1 inhibitors (MedchemExpress, HY-128661, 10mM (1mL in DMSO), USA)to treat the cells.

    Techniques: CCK-8 Assay, Western Blot, Transwell Assay, Migration, Wound Healing Assay

    IDH1 inhibitor attenuates the effect of SKP2 inhibitor. A CCK-8 was used to detect the cell proliferation after 3 days of treatment with different inhibitors. B Edu reagent was used to detect cell proliferation at different times and 3 days after treatment. C Cell migration ability was detected by Wound-healing assay. Ability of cells to form colonies after 14 days of inhibitor treatment. D Cell cycle plots under different inhibitor treatments

    Journal: BMC Cancer

    Article Title: SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism

    doi: 10.1186/s12885-025-14644-5

    Figure Lengend Snippet: IDH1 inhibitor attenuates the effect of SKP2 inhibitor. A CCK-8 was used to detect the cell proliferation after 3 days of treatment with different inhibitors. B Edu reagent was used to detect cell proliferation at different times and 3 days after treatment. C Cell migration ability was detected by Wound-healing assay. Ability of cells to form colonies after 14 days of inhibitor treatment. D Cell cycle plots under different inhibitor treatments

    Article Snippet: To treat the cells, we used SKP2 inhibitors(Selleck, S8652, 10mM (1mL in DMSO), China) as well as IDH1 inhibitors (MedchemExpress, HY-128661, 10mM (1mL in DMSO), USA)to treat the cells.

    Techniques: CCK-8 Assay, Migration, Wound Healing Assay

    IDH1 inhibitor attenuates the effect of SKP2 inhibitor. A Flow plots of apoptosis in response to different inhibitor treatments. B & C Fluorescence plot and flow plot of glucose uptake assay in cells treated with different inhibitors for 3 days. D & E Fluorescence and flow plots of mitochondrial membrane potential at 3 days after treatment with different inhibitors. F Histogram of glucose metabolism in cells treated with different inhibitor. Statistical differences are indicated as follows: * p < 0.05, * * p < 0.01, * * * p < 0.001, * * * * p < 0.0001

    Journal: BMC Cancer

    Article Title: SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism

    doi: 10.1186/s12885-025-14644-5

    Figure Lengend Snippet: IDH1 inhibitor attenuates the effect of SKP2 inhibitor. A Flow plots of apoptosis in response to different inhibitor treatments. B & C Fluorescence plot and flow plot of glucose uptake assay in cells treated with different inhibitors for 3 days. D & E Fluorescence and flow plots of mitochondrial membrane potential at 3 days after treatment with different inhibitors. F Histogram of glucose metabolism in cells treated with different inhibitor. Statistical differences are indicated as follows: * p < 0.05, * * p < 0.01, * * * p < 0.001, * * * * p < 0.0001

    Article Snippet: To treat the cells, we used SKP2 inhibitors(Selleck, S8652, 10mM (1mL in DMSO), China) as well as IDH1 inhibitors (MedchemExpress, HY-128661, 10mM (1mL in DMSO), USA)to treat the cells.

    Techniques: Fluorescence, Membrane