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bms193885  (MedChemExpress)


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    MedChemExpress bms193885
    VGLUT3 + sensory fibers alleviate mechanical and chemical itch via spinal NPY-Y1R and DYN-KOR-signaling pathway, respectively. A, F Schematic of experimental design. B, C Pretreatment of Y1 receptor antagonist <t>(BMS193885)</t> does not alter the inhibitory effect of VGLUT3 + fibers on both histamine and chloroquine itch models. D, E Pretreatment of BMS193885 abrogates the inhibitory effect of VGLUT3 + fibers on mechanical itch and reduces the degree of inhibition. G, H Pretreatment of KOR antagonist (norBNI) attenuates the degree of itch inhibition mediated by VGLUT3 + fibers on both histamine and chloroquine itch models. I,J Pretreatment of KOR antagonist (norBNI) does not alter VGLUT3 + fiber-mediated suppression of mechanical itch. Data are represented as mean with SEM and assessed using two-tailed unpaired t test, exact p-values are reported for all statistical comparisons
    Bms193885, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bms193885/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    bms193885 - by Bioz Stars, 2026-02
    94/100 stars

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    1) Product Images from "Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition"

    Article Title: Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition

    Journal: Molecular Brain

    doi: 10.1186/s13041-025-01245-3

    VGLUT3 + sensory fibers alleviate mechanical and chemical itch via spinal NPY-Y1R and DYN-KOR-signaling pathway, respectively. A, F Schematic of experimental design. B, C Pretreatment of Y1 receptor antagonist (BMS193885) does not alter the inhibitory effect of VGLUT3 + fibers on both histamine and chloroquine itch models. D, E Pretreatment of BMS193885 abrogates the inhibitory effect of VGLUT3 + fibers on mechanical itch and reduces the degree of inhibition. G, H Pretreatment of KOR antagonist (norBNI) attenuates the degree of itch inhibition mediated by VGLUT3 + fibers on both histamine and chloroquine itch models. I,J Pretreatment of KOR antagonist (norBNI) does not alter VGLUT3 + fiber-mediated suppression of mechanical itch. Data are represented as mean with SEM and assessed using two-tailed unpaired t test, exact p-values are reported for all statistical comparisons
    Figure Legend Snippet: VGLUT3 + sensory fibers alleviate mechanical and chemical itch via spinal NPY-Y1R and DYN-KOR-signaling pathway, respectively. A, F Schematic of experimental design. B, C Pretreatment of Y1 receptor antagonist (BMS193885) does not alter the inhibitory effect of VGLUT3 + fibers on both histamine and chloroquine itch models. D, E Pretreatment of BMS193885 abrogates the inhibitory effect of VGLUT3 + fibers on mechanical itch and reduces the degree of inhibition. G, H Pretreatment of KOR antagonist (norBNI) attenuates the degree of itch inhibition mediated by VGLUT3 + fibers on both histamine and chloroquine itch models. I,J Pretreatment of KOR antagonist (norBNI) does not alter VGLUT3 + fiber-mediated suppression of mechanical itch. Data are represented as mean with SEM and assessed using two-tailed unpaired t test, exact p-values are reported for all statistical comparisons

    Techniques Used: Inhibition, Two Tailed Test

    Schematic model of the spinal inhibitory circuit for DRG VGLUT3 -mediated suppression of itch. A Optogenetic activation of VGLUT3-expressing LTMR terminals inhibits itch signaling in the spinal cord through distinct pathways. Chemical itch is suppressed via a dynorphin (DYN)-mediated inhibitory pathway, where VGLUT3⁺ LTMR activation recruits DYN⁺ inhibitory interneurons to suppress κ-opioid receptor (KOR)-expressing pruriceptive neurons. This anti-pruritic effect is abolished by the selective KOR antagonist norBNI. B Mechanical itch is inhibited through a distinct neuropeptide Y (NPY)-dependent pathway, where VGLUT3⁺ LTMR activation recruits NPY⁺ inhibitory interneurons to suppress itch-transmission neurons via Y1 receptor (Y1R) signaling. This anti-pruritic effect is selectively blocked by the Y1R antagonist BMS193885
    Figure Legend Snippet: Schematic model of the spinal inhibitory circuit for DRG VGLUT3 -mediated suppression of itch. A Optogenetic activation of VGLUT3-expressing LTMR terminals inhibits itch signaling in the spinal cord through distinct pathways. Chemical itch is suppressed via a dynorphin (DYN)-mediated inhibitory pathway, where VGLUT3⁺ LTMR activation recruits DYN⁺ inhibitory interneurons to suppress κ-opioid receptor (KOR)-expressing pruriceptive neurons. This anti-pruritic effect is abolished by the selective KOR antagonist norBNI. B Mechanical itch is inhibited through a distinct neuropeptide Y (NPY)-dependent pathway, where VGLUT3⁺ LTMR activation recruits NPY⁺ inhibitory interneurons to suppress itch-transmission neurons via Y1 receptor (Y1R) signaling. This anti-pruritic effect is selectively blocked by the Y1R antagonist BMS193885

    Techniques Used: Activation Assay, Expressing, Transmission Assay



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    bms193885  (MedChemExpress)
    94
    MedChemExpress bms193885
    VGLUT3 + sensory fibers alleviate mechanical and chemical itch via spinal NPY-Y1R and DYN-KOR-signaling pathway, respectively. A, F Schematic of experimental design. B, C Pretreatment of Y1 receptor antagonist <t>(BMS193885)</t> does not alter the inhibitory effect of VGLUT3 + fibers on both histamine and chloroquine itch models. D, E Pretreatment of BMS193885 abrogates the inhibitory effect of VGLUT3 + fibers on mechanical itch and reduces the degree of inhibition. G, H Pretreatment of KOR antagonist (norBNI) attenuates the degree of itch inhibition mediated by VGLUT3 + fibers on both histamine and chloroquine itch models. I,J Pretreatment of KOR antagonist (norBNI) does not alter VGLUT3 + fiber-mediated suppression of mechanical itch. Data are represented as mean with SEM and assessed using two-tailed unpaired t test, exact p-values are reported for all statistical comparisons
    Bms193885, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bms193885/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    bms193885 - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier
    bms-193885  (MedChemExpress)
    94
    MedChemExpress bms-193885
    VGLUT3 + sensory fibers alleviate mechanical and chemical itch via spinal NPY-Y1R and DYN-KOR-signaling pathway, respectively. A, F Schematic of experimental design. B, C Pretreatment of Y1 receptor antagonist <t>(BMS193885)</t> does not alter the inhibitory effect of VGLUT3 + fibers on both histamine and chloroquine itch models. D, E Pretreatment of BMS193885 abrogates the inhibitory effect of VGLUT3 + fibers on mechanical itch and reduces the degree of inhibition. G, H Pretreatment of KOR antagonist (norBNI) attenuates the degree of itch inhibition mediated by VGLUT3 + fibers on both histamine and chloroquine itch models. I,J Pretreatment of KOR antagonist (norBNI) does not alter VGLUT3 + fiber-mediated suppression of mechanical itch. Data are represented as mean with SEM and assessed using two-tailed unpaired t test, exact p-values are reported for all statistical comparisons
    Bms 193885, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bms-193885/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    bms-193885 - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    VGLUT3 + sensory fibers alleviate mechanical and chemical itch via spinal NPY-Y1R and DYN-KOR-signaling pathway, respectively. A, F Schematic of experimental design. B, C Pretreatment of Y1 receptor antagonist (BMS193885) does not alter the inhibitory effect of VGLUT3 + fibers on both histamine and chloroquine itch models. D, E Pretreatment of BMS193885 abrogates the inhibitory effect of VGLUT3 + fibers on mechanical itch and reduces the degree of inhibition. G, H Pretreatment of KOR antagonist (norBNI) attenuates the degree of itch inhibition mediated by VGLUT3 + fibers on both histamine and chloroquine itch models. I,J Pretreatment of KOR antagonist (norBNI) does not alter VGLUT3 + fiber-mediated suppression of mechanical itch. Data are represented as mean with SEM and assessed using two-tailed unpaired t test, exact p-values are reported for all statistical comparisons

    Journal: Molecular Brain

    Article Title: Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition

    doi: 10.1186/s13041-025-01245-3

    Figure Lengend Snippet: VGLUT3 + sensory fibers alleviate mechanical and chemical itch via spinal NPY-Y1R and DYN-KOR-signaling pathway, respectively. A, F Schematic of experimental design. B, C Pretreatment of Y1 receptor antagonist (BMS193885) does not alter the inhibitory effect of VGLUT3 + fibers on both histamine and chloroquine itch models. D, E Pretreatment of BMS193885 abrogates the inhibitory effect of VGLUT3 + fibers on mechanical itch and reduces the degree of inhibition. G, H Pretreatment of KOR antagonist (norBNI) attenuates the degree of itch inhibition mediated by VGLUT3 + fibers on both histamine and chloroquine itch models. I,J Pretreatment of KOR antagonist (norBNI) does not alter VGLUT3 + fiber-mediated suppression of mechanical itch. Data are represented as mean with SEM and assessed using two-tailed unpaired t test, exact p-values are reported for all statistical comparisons

    Article Snippet: The nor-Binaltorphimine (nor-BNI) (Cat# AB120078 , Abcam) and BMS193885 (Cat#HY-120619, MCE) were dissolved in saline.

    Techniques: Inhibition, Two Tailed Test

    Schematic model of the spinal inhibitory circuit for DRG VGLUT3 -mediated suppression of itch. A Optogenetic activation of VGLUT3-expressing LTMR terminals inhibits itch signaling in the spinal cord through distinct pathways. Chemical itch is suppressed via a dynorphin (DYN)-mediated inhibitory pathway, where VGLUT3⁺ LTMR activation recruits DYN⁺ inhibitory interneurons to suppress κ-opioid receptor (KOR)-expressing pruriceptive neurons. This anti-pruritic effect is abolished by the selective KOR antagonist norBNI. B Mechanical itch is inhibited through a distinct neuropeptide Y (NPY)-dependent pathway, where VGLUT3⁺ LTMR activation recruits NPY⁺ inhibitory interneurons to suppress itch-transmission neurons via Y1 receptor (Y1R) signaling. This anti-pruritic effect is selectively blocked by the Y1R antagonist BMS193885

    Journal: Molecular Brain

    Article Title: Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition

    doi: 10.1186/s13041-025-01245-3

    Figure Lengend Snippet: Schematic model of the spinal inhibitory circuit for DRG VGLUT3 -mediated suppression of itch. A Optogenetic activation of VGLUT3-expressing LTMR terminals inhibits itch signaling in the spinal cord through distinct pathways. Chemical itch is suppressed via a dynorphin (DYN)-mediated inhibitory pathway, where VGLUT3⁺ LTMR activation recruits DYN⁺ inhibitory interneurons to suppress κ-opioid receptor (KOR)-expressing pruriceptive neurons. This anti-pruritic effect is abolished by the selective KOR antagonist norBNI. B Mechanical itch is inhibited through a distinct neuropeptide Y (NPY)-dependent pathway, where VGLUT3⁺ LTMR activation recruits NPY⁺ inhibitory interneurons to suppress itch-transmission neurons via Y1 receptor (Y1R) signaling. This anti-pruritic effect is selectively blocked by the Y1R antagonist BMS193885

    Article Snippet: The nor-Binaltorphimine (nor-BNI) (Cat# AB120078 , Abcam) and BMS193885 (Cat#HY-120619, MCE) were dissolved in saline.

    Techniques: Activation Assay, Expressing, Transmission Assay