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furamidine dihydrochloride db75  (MedChemExpress)


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    MedChemExpress furamidine dihydrochloride db75
    Furamidine Dihydrochloride Db75, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/furamidine dihydrochloride db75/product/MedChemExpress
    Average 93 stars, based on 6 article reviews
    furamidine dihydrochloride db75 - by Bioz Stars, 2026-02
    93/100 stars

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    MedChemExpress furamidine dihydrochloride
    The effect of PRMT1 on the methylation of STAT3 and FAS transcription. U‐2 OS cells transfected with pLenti control or pLenti‐PRMT1 plasmids were administrated with 5 µM <t>furamidine</t> <t>dihydrochloride</t> <t>(DB75),</t> a PRMT1 inhibitor, for 8 h. A, The expression of PRMT1 was detected by Western blot. B, Methylation of STAT3 was tested by immunoprecipitation with anti‐mono and dimethyl‐arginine antibody (MetR) and immunoblotting with an antibody against STAT3. C, The phosphorylation of STAT3 was tested in nucleus by Western blot. D, The mRNA level of FAS was detected by qPCR assay. The mRNA analysis result is expressed as the fold increase over control. n = 3. * P < 0.05 vs the Con group. ** P < 0.01 vs the Con group
    Furamidine Dihydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 93 stars, based on 1 article reviews
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    The effect of PRMT1 on the methylation of STAT3 and FAS transcription. U‐2 OS cells transfected with pLenti control or pLenti‐PRMT1 plasmids were administrated with 5 µM furamidine dihydrochloride (DB75), a PRMT1 inhibitor, for 8 h. A, The expression of PRMT1 was detected by Western blot. B, Methylation of STAT3 was tested by immunoprecipitation with anti‐mono and dimethyl‐arginine antibody (MetR) and immunoblotting with an antibody against STAT3. C, The phosphorylation of STAT3 was tested in nucleus by Western blot. D, The mRNA level of FAS was detected by qPCR assay. The mRNA analysis result is expressed as the fold increase over control. n = 3. * P < 0.05 vs the Con group. ** P < 0.01 vs the Con group

    Journal: Journal of Cellular and Molecular Medicine

    Article Title: Geranylgeranylacetone promotes human osteosarcoma cell apoptosis by inducing the degradation of PRMT1 through the E3 ubiquitin ligase CHIP

    doi: 10.1111/jcmm.16725

    Figure Lengend Snippet: The effect of PRMT1 on the methylation of STAT3 and FAS transcription. U‐2 OS cells transfected with pLenti control or pLenti‐PRMT1 plasmids were administrated with 5 µM furamidine dihydrochloride (DB75), a PRMT1 inhibitor, for 8 h. A, The expression of PRMT1 was detected by Western blot. B, Methylation of STAT3 was tested by immunoprecipitation with anti‐mono and dimethyl‐arginine antibody (MetR) and immunoblotting with an antibody against STAT3. C, The phosphorylation of STAT3 was tested in nucleus by Western blot. D, The mRNA level of FAS was detected by qPCR assay. The mRNA analysis result is expressed as the fold increase over control. n = 3. * P < 0.05 vs the Con group. ** P < 0.01 vs the Con group

    Article Snippet: Furamidine dihydrochloride (DB75, HY‐110137) was obtained from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques: Methylation, Transfection, Control, Expressing, Western Blot, Immunoprecipitation