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aacocf3  (MedChemExpress)


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    MedChemExpress aacocf3
    Effects of BZP on the expression of differentially expressed genes (DEGs) in rUCCAO mice. (A) Volcano plot visualising DEGs induced by BZP. The grey dots indicate genes with no significant difference, the red dots indicate upregulated DEGs, and blue dots indicate down-regulated DEGs. (B) Heatmap of DEGs. (C) Significantly enriched KEGG pathway. (D) Transfection of lenti-12/15-LOX into HT22 cells. Fluoresce microscope was used to observe the transfection efficacy of 12/15-LOX-OE-GFP in HT22 cells (×200 magnification). (E, F) Western blot analysis to detect the expression of 12/15-LOX in control and overexpression (OE) groups. (G) Effect of 12/15-LOX OE on the relative proliferation of HT22 cells. (H–L) Protein expression levels of 12/15-LOX, cPLA 2 , p38 MAPK, p-p38 MAPK, and TNF-α in OE, OE + SB203580, OE + <t>AACOCF3,</t> and OE + BZP groups using Western blot analysis. Data are presented as means ± standard deviation (* p < 0.05, ** p < 0.01, *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01 vs. OE group).
    Aacocf3, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/aacocf3/product/MedChemExpress
    Average 93 stars, based on 6 article reviews
    aacocf3 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Inhibition of 12/15-LOX hyperactivation mitigates cognitive decline in a chronic cerebral hypoperfusion mouse model and in H 2 O 2 -induced HT22 cells: therapeutic effects of brozopine"

    Article Title: Inhibition of 12/15-LOX hyperactivation mitigates cognitive decline in a chronic cerebral hypoperfusion mouse model and in H 2 O 2 -induced HT22 cells: therapeutic effects of brozopine

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    doi: 10.1080/14756366.2025.2547259

    Effects of BZP on the expression of differentially expressed genes (DEGs) in rUCCAO mice. (A) Volcano plot visualising DEGs induced by BZP. The grey dots indicate genes with no significant difference, the red dots indicate upregulated DEGs, and blue dots indicate down-regulated DEGs. (B) Heatmap of DEGs. (C) Significantly enriched KEGG pathway. (D) Transfection of lenti-12/15-LOX into HT22 cells. Fluoresce microscope was used to observe the transfection efficacy of 12/15-LOX-OE-GFP in HT22 cells (×200 magnification). (E, F) Western blot analysis to detect the expression of 12/15-LOX in control and overexpression (OE) groups. (G) Effect of 12/15-LOX OE on the relative proliferation of HT22 cells. (H–L) Protein expression levels of 12/15-LOX, cPLA 2 , p38 MAPK, p-p38 MAPK, and TNF-α in OE, OE + SB203580, OE + AACOCF3, and OE + BZP groups using Western blot analysis. Data are presented as means ± standard deviation (* p < 0.05, ** p < 0.01, *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01 vs. OE group).
    Figure Legend Snippet: Effects of BZP on the expression of differentially expressed genes (DEGs) in rUCCAO mice. (A) Volcano plot visualising DEGs induced by BZP. The grey dots indicate genes with no significant difference, the red dots indicate upregulated DEGs, and blue dots indicate down-regulated DEGs. (B) Heatmap of DEGs. (C) Significantly enriched KEGG pathway. (D) Transfection of lenti-12/15-LOX into HT22 cells. Fluoresce microscope was used to observe the transfection efficacy of 12/15-LOX-OE-GFP in HT22 cells (×200 magnification). (E, F) Western blot analysis to detect the expression of 12/15-LOX in control and overexpression (OE) groups. (G) Effect of 12/15-LOX OE on the relative proliferation of HT22 cells. (H–L) Protein expression levels of 12/15-LOX, cPLA 2 , p38 MAPK, p-p38 MAPK, and TNF-α in OE, OE + SB203580, OE + AACOCF3, and OE + BZP groups using Western blot analysis. Data are presented as means ± standard deviation (* p < 0.05, ** p < 0.01, *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01 vs. OE group).

    Techniques Used: Expressing, Transfection, Microscopy, Western Blot, Control, Over Expression, Standard Deviation



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    Effects of BZP on the expression of differentially expressed genes (DEGs) in rUCCAO mice. (A) Volcano plot visualising DEGs induced by BZP. The grey dots indicate genes with no significant difference, the red dots indicate upregulated DEGs, and blue dots indicate down-regulated DEGs. (B) Heatmap of DEGs. (C) Significantly enriched KEGG pathway. (D) Transfection of lenti-12/15-LOX into HT22 cells. Fluoresce microscope was used to observe the transfection efficacy of 12/15-LOX-OE-GFP in HT22 cells (×200 magnification). (E, F) Western blot analysis to detect the expression of 12/15-LOX in control and overexpression (OE) groups. (G) Effect of 12/15-LOX OE on the relative proliferation of HT22 cells. (H–L) Protein expression levels of 12/15-LOX, cPLA 2 , p38 MAPK, p-p38 MAPK, and TNF-α in OE, OE + SB203580, OE + <t>AACOCF3,</t> and OE + BZP groups using Western blot analysis. Data are presented as means ± standard deviation (* p < 0.05, ** p < 0.01, *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01 vs. OE group).
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    Image Search Results


    Effects of BZP on the expression of differentially expressed genes (DEGs) in rUCCAO mice. (A) Volcano plot visualising DEGs induced by BZP. The grey dots indicate genes with no significant difference, the red dots indicate upregulated DEGs, and blue dots indicate down-regulated DEGs. (B) Heatmap of DEGs. (C) Significantly enriched KEGG pathway. (D) Transfection of lenti-12/15-LOX into HT22 cells. Fluoresce microscope was used to observe the transfection efficacy of 12/15-LOX-OE-GFP in HT22 cells (×200 magnification). (E, F) Western blot analysis to detect the expression of 12/15-LOX in control and overexpression (OE) groups. (G) Effect of 12/15-LOX OE on the relative proliferation of HT22 cells. (H–L) Protein expression levels of 12/15-LOX, cPLA 2 , p38 MAPK, p-p38 MAPK, and TNF-α in OE, OE + SB203580, OE + AACOCF3, and OE + BZP groups using Western blot analysis. Data are presented as means ± standard deviation (* p < 0.05, ** p < 0.01, *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01 vs. OE group).

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Inhibition of 12/15-LOX hyperactivation mitigates cognitive decline in a chronic cerebral hypoperfusion mouse model and in H 2 O 2 -induced HT22 cells: therapeutic effects of brozopine

    doi: 10.1080/14756366.2025.2547259

    Figure Lengend Snippet: Effects of BZP on the expression of differentially expressed genes (DEGs) in rUCCAO mice. (A) Volcano plot visualising DEGs induced by BZP. The grey dots indicate genes with no significant difference, the red dots indicate upregulated DEGs, and blue dots indicate down-regulated DEGs. (B) Heatmap of DEGs. (C) Significantly enriched KEGG pathway. (D) Transfection of lenti-12/15-LOX into HT22 cells. Fluoresce microscope was used to observe the transfection efficacy of 12/15-LOX-OE-GFP in HT22 cells (×200 magnification). (E, F) Western blot analysis to detect the expression of 12/15-LOX in control and overexpression (OE) groups. (G) Effect of 12/15-LOX OE on the relative proliferation of HT22 cells. (H–L) Protein expression levels of 12/15-LOX, cPLA 2 , p38 MAPK, p-p38 MAPK, and TNF-α in OE, OE + SB203580, OE + AACOCF3, and OE + BZP groups using Western blot analysis. Data are presented as means ± standard deviation (* p < 0.05, ** p < 0.01, *** p < 0.001 vs. control group, # p < 0.05, ## p < 0.01 vs. OE group).

    Article Snippet: Baicalein (purity: ≥98%; LOT: 122452) and AACOCF3 (purity: ≥98%; LOT: 438371) were purchased from MedChemExpress Bio-Technology Co., Ltd. (Shanghai, China).

    Techniques: Expressing, Transfection, Microscopy, Western Blot, Control, Over Expression, Standard Deviation