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fxr antagonist guggulsterone  (MedChemExpress)


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    MedChemExpress fxr antagonist guggulsterone
    (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and <t>DSS/LCA/guggulsterone</t> (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).
    Fxr Antagonist Guggulsterone, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fxr antagonist guggulsterone/product/MedChemExpress
    Average 94 stars, based on 26 article reviews
    fxr antagonist guggulsterone - by Bioz Stars, 2026-02
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    Images

    1) Product Images from "Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system"

    Article Title: Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system

    Journal: bioRxiv

    doi: 10.1101/2025.11.07.686950

    (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and DSS/LCA/guggulsterone (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).
    Figure Legend Snippet: (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and DSS/LCA/guggulsterone (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).

    Techniques Used: Permeability, Two Tailed Test, Fluorescence



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    (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and <t>DSS/LCA/guggulsterone</t> (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).
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    (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and <t>DSS/LCA/guggulsterone</t> (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).
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    (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and <t>DSS/LCA/guggulsterone</t> (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).
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    (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and <t>DSS/LCA/guggulsterone</t> (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).
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    Image Search Results


    (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and DSS/LCA/guggulsterone (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).

    Journal: bioRxiv

    Article Title: Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system

    doi: 10.1101/2025.11.07.686950

    Figure Lengend Snippet: (A) Measurement of FITC-dextran permeability (shown as calculated permeability coefficient P app in cm/s) after 48 h. Bars represent mean ± SD of 3 independent experiments (n = 3) with 3 individual MDM donors. Significances are directly indicated as written p-values (Paired two-tailed t test). One data point (GMM +LPS +1 µM SBI-115) was excluded due to leakage of the biochip. (B) Quantification of Ki-67 mean fluorescence intensity (MFI) within the identified nuclei in untreated models (w/o) or models treated with DSS (+DSS), DSS/LCA (+DSS +LCA), DSS/LCA/SBI-115 (1 µM) (+DSS +LCA +SBI-115), and DSS/LCA/guggulsterone (3 µM) (+DSS +LCA +Guggul). Violin plots with indicated median and quartiles of 3 independent experiments (n = 3) with 3 individual MDM donors. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 (Unpaired two-tailed t test).

    Article Snippet: FXR antagonist guggulsterone (CAS number: 95975-55-6, MedChemExpress) was solubilized in DMSO to a stock concentration of 50 mM.

    Techniques: Permeability, Two Tailed Test, Fluorescence