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senolytic abt263  (MedChemExpress)


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    MedChemExpress senolytic abt263
    Preparation and characterization of ANCM@SHM. (a) Schematic diagram of NCM preparation. (b) Representative TEM images of native CM and NCM. Bar: 50 nm. (c–d) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of native CM and NCM measured by DLS. (e) Representative TEM images of Lipo, A-lipo, and ANCM. Bar: 50 nm. (f–g) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of Lipo, A-lipo, and ANCM measured by DLS. (h) Representative confocal fluorescence micrographs showing red fluorescently labeled A-lipo and green fluorescently labeled NCM fusing into gold fluorescent ANCM. Bar: 10 μm. (i) Quantification of NKG2D on the surface of CM, NCM, and ANCM nanoparticles by flow cytometry. (j–k) Encapsulation efficiency (EE) (n = 3) and loading efficiency (LE) (n = 3) of <t>ABT263.</t> (l) Representative SEM image of ANCM@SHM. Bar: 100 μm. (m) Representative fluorescence image of PKH67-ANCM@SHM captured by confocal microscope. Bar: 100 μm.
    Senolytic Abt263, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 190 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/senolytic abt263/product/MedChemExpress
    Average 97 stars, based on 190 article reviews
    senolytic abt263 - by Bioz Stars, 2026-02
    97/100 stars

    Images

    1) Product Images from "Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion"

    Article Title: Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion

    Journal: Bioactive Materials

    doi: 10.1016/j.bioactmat.2025.11.038

    Preparation and characterization of ANCM@SHM. (a) Schematic diagram of NCM preparation. (b) Representative TEM images of native CM and NCM. Bar: 50 nm. (c–d) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of native CM and NCM measured by DLS. (e) Representative TEM images of Lipo, A-lipo, and ANCM. Bar: 50 nm. (f–g) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of Lipo, A-lipo, and ANCM measured by DLS. (h) Representative confocal fluorescence micrographs showing red fluorescently labeled A-lipo and green fluorescently labeled NCM fusing into gold fluorescent ANCM. Bar: 10 μm. (i) Quantification of NKG2D on the surface of CM, NCM, and ANCM nanoparticles by flow cytometry. (j–k) Encapsulation efficiency (EE) (n = 3) and loading efficiency (LE) (n = 3) of ABT263. (l) Representative SEM image of ANCM@SHM. Bar: 100 μm. (m) Representative fluorescence image of PKH67-ANCM@SHM captured by confocal microscope. Bar: 100 μm.
    Figure Legend Snippet: Preparation and characterization of ANCM@SHM. (a) Schematic diagram of NCM preparation. (b) Representative TEM images of native CM and NCM. Bar: 50 nm. (c–d) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of native CM and NCM measured by DLS. (e) Representative TEM images of Lipo, A-lipo, and ANCM. Bar: 50 nm. (f–g) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of Lipo, A-lipo, and ANCM measured by DLS. (h) Representative confocal fluorescence micrographs showing red fluorescently labeled A-lipo and green fluorescently labeled NCM fusing into gold fluorescent ANCM. Bar: 10 μm. (i) Quantification of NKG2D on the surface of CM, NCM, and ANCM nanoparticles by flow cytometry. (j–k) Encapsulation efficiency (EE) (n = 3) and loading efficiency (LE) (n = 3) of ABT263. (l) Representative SEM image of ANCM@SHM. Bar: 100 μm. (m) Representative fluorescence image of PKH67-ANCM@SHM captured by confocal microscope. Bar: 100 μm.

    Techniques Used: Zeta Potential Analyzer, Fluorescence, Labeling, Flow Cytometry, Encapsulation, Microscopy

    ANCM@SHM facilitates apoptosis of senescent chondrocytes through triggering MOMP. (a–b) Representative immunofluorescence images with quantitative analysis showing mitochondrial Cyt c co-localization in ANCM@SHM-treated cells (n = 4). Bar: 5 μm. (c–d) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with ANCM@SHM (n = 4). Bar: 5 μm. (e–f) Mitochondrial Cyt c co-localization assessment in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (g–h) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (i–j) Representative dot plots and statistical analysis of apoptosis in cells treated with BAI1 and ANCM@SHM evaluated by flow cytometry (n = 3). (k–l) WB analysis of apoptotic protein expression post treatment with BAI1 and ANCM@SHM (n = 3). (m) Schematic diagram of mechanism of ABT263-induced cell apoptosis. The data are expressed as the mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 and ∗∗∗ p < 0.001. Statistical significance was explored through the one-way ANOVA.
    Figure Legend Snippet: ANCM@SHM facilitates apoptosis of senescent chondrocytes through triggering MOMP. (a–b) Representative immunofluorescence images with quantitative analysis showing mitochondrial Cyt c co-localization in ANCM@SHM-treated cells (n = 4). Bar: 5 μm. (c–d) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with ANCM@SHM (n = 4). Bar: 5 μm. (e–f) Mitochondrial Cyt c co-localization assessment in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (g–h) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (i–j) Representative dot plots and statistical analysis of apoptosis in cells treated with BAI1 and ANCM@SHM evaluated by flow cytometry (n = 3). (k–l) WB analysis of apoptotic protein expression post treatment with BAI1 and ANCM@SHM (n = 3). (m) Schematic diagram of mechanism of ABT263-induced cell apoptosis. The data are expressed as the mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 and ∗∗∗ p < 0.001. Statistical significance was explored through the one-way ANOVA.

    Techniques Used: Immunofluorescence, Fluorescence, Flow Cytometry, Expressing



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    Preparation and characterization of ANCM@SHM. (a) Schematic diagram of NCM preparation. (b) Representative TEM images of native CM and NCM. Bar: 50 nm. (c–d) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of native CM and NCM measured by DLS. (e) Representative TEM images of Lipo, A-lipo, and ANCM. Bar: 50 nm. (f–g) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of Lipo, A-lipo, and ANCM measured by DLS. (h) Representative confocal fluorescence micrographs showing red fluorescently labeled A-lipo and green fluorescently labeled NCM fusing into gold fluorescent ANCM. Bar: 10 μm. (i) Quantification of NKG2D on the surface of CM, NCM, and ANCM nanoparticles by flow cytometry. (j–k) Encapsulation efficiency (EE) (n = 3) and loading efficiency (LE) (n = 3) of <t>ABT263.</t> (l) Representative SEM image of ANCM@SHM. Bar: 100 μm. (m) Representative fluorescence image of PKH67-ANCM@SHM captured by confocal microscope. Bar: 100 μm.
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    Preparation and characterization of ANCM@SHM. (a) Schematic diagram of NCM preparation. (b) Representative TEM images of native CM and NCM. Bar: 50 nm. (c–d) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of native CM and NCM measured by DLS. (e) Representative TEM images of Lipo, A-lipo, and ANCM. Bar: 50 nm. (f–g) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of Lipo, A-lipo, and ANCM measured by DLS. (h) Representative confocal fluorescence micrographs showing red fluorescently labeled A-lipo and green fluorescently labeled NCM fusing into gold fluorescent ANCM. Bar: 10 μm. (i) Quantification of NKG2D on the surface of CM, NCM, and ANCM nanoparticles by flow cytometry. (j–k) Encapsulation efficiency (EE) (n = 3) and loading efficiency (LE) (n = 3) of <t>ABT263.</t> (l) Representative SEM image of ANCM@SHM. Bar: 100 μm. (m) Representative fluorescence image of PKH67-ANCM@SHM captured by confocal microscope. Bar: 100 μm.
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    Preparation and characterization of ANCM@SHM. (a) Schematic diagram of NCM preparation. (b) Representative TEM images of native CM and NCM. Bar: 50 nm. (c–d) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of native CM and NCM measured by DLS. (e) Representative TEM images of Lipo, A-lipo, and ANCM. Bar: 50 nm. (f–g) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of Lipo, A-lipo, and ANCM measured by DLS. (h) Representative confocal fluorescence micrographs showing red fluorescently labeled A-lipo and green fluorescently labeled NCM fusing into gold fluorescent ANCM. Bar: 10 μm. (i) Quantification of NKG2D on the surface of CM, NCM, and ANCM nanoparticles by flow cytometry. (j–k) Encapsulation efficiency (EE) (n = 3) and loading efficiency (LE) (n = 3) of ABT263. (l) Representative SEM image of ANCM@SHM. Bar: 100 μm. (m) Representative fluorescence image of PKH67-ANCM@SHM captured by confocal microscope. Bar: 100 μm.

    Journal: Bioactive Materials

    Article Title: Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion

    doi: 10.1016/j.bioactmat.2025.11.038

    Figure Lengend Snippet: Preparation and characterization of ANCM@SHM. (a) Schematic diagram of NCM preparation. (b) Representative TEM images of native CM and NCM. Bar: 50 nm. (c–d) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of native CM and NCM measured by DLS. (e) Representative TEM images of Lipo, A-lipo, and ANCM. Bar: 50 nm. (f–g) Zeta potential (n = 3), particle size (n = 3), and PDI (n = 3) of Lipo, A-lipo, and ANCM measured by DLS. (h) Representative confocal fluorescence micrographs showing red fluorescently labeled A-lipo and green fluorescently labeled NCM fusing into gold fluorescent ANCM. Bar: 10 μm. (i) Quantification of NKG2D on the surface of CM, NCM, and ANCM nanoparticles by flow cytometry. (j–k) Encapsulation efficiency (EE) (n = 3) and loading efficiency (LE) (n = 3) of ABT263. (l) Representative SEM image of ANCM@SHM. Bar: 100 μm. (m) Representative fluorescence image of PKH67-ANCM@SHM captured by confocal microscope. Bar: 100 μm.

    Article Snippet: Cholesterol (Aladdin, China), lecithin (Macklin, China), and senolytic ABT263 (MCE, China) were accurately weighed at a mass ratio of 8:2:1 and subsequently dissolved in dichloromethane.

    Techniques: Zeta Potential Analyzer, Fluorescence, Labeling, Flow Cytometry, Encapsulation, Microscopy

    ANCM@SHM facilitates apoptosis of senescent chondrocytes through triggering MOMP. (a–b) Representative immunofluorescence images with quantitative analysis showing mitochondrial Cyt c co-localization in ANCM@SHM-treated cells (n = 4). Bar: 5 μm. (c–d) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with ANCM@SHM (n = 4). Bar: 5 μm. (e–f) Mitochondrial Cyt c co-localization assessment in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (g–h) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (i–j) Representative dot plots and statistical analysis of apoptosis in cells treated with BAI1 and ANCM@SHM evaluated by flow cytometry (n = 3). (k–l) WB analysis of apoptotic protein expression post treatment with BAI1 and ANCM@SHM (n = 3). (m) Schematic diagram of mechanism of ABT263-induced cell apoptosis. The data are expressed as the mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 and ∗∗∗ p < 0.001. Statistical significance was explored through the one-way ANOVA.

    Journal: Bioactive Materials

    Article Title: Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion

    doi: 10.1016/j.bioactmat.2025.11.038

    Figure Lengend Snippet: ANCM@SHM facilitates apoptosis of senescent chondrocytes through triggering MOMP. (a–b) Representative immunofluorescence images with quantitative analysis showing mitochondrial Cyt c co-localization in ANCM@SHM-treated cells (n = 4). Bar: 5 μm. (c–d) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with ANCM@SHM (n = 4). Bar: 5 μm. (e–f) Mitochondrial Cyt c co-localization assessment in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (g–h) Mitochondrial BAX6A7 fluorescence images and statistical analysis in cells treated with BAI1 and ANCM@SHM (n = 4). Bar: 5 μm. (i–j) Representative dot plots and statistical analysis of apoptosis in cells treated with BAI1 and ANCM@SHM evaluated by flow cytometry (n = 3). (k–l) WB analysis of apoptotic protein expression post treatment with BAI1 and ANCM@SHM (n = 3). (m) Schematic diagram of mechanism of ABT263-induced cell apoptosis. The data are expressed as the mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 and ∗∗∗ p < 0.001. Statistical significance was explored through the one-way ANOVA.

    Article Snippet: Cholesterol (Aladdin, China), lecithin (Macklin, China), and senolytic ABT263 (MCE, China) were accurately weighed at a mass ratio of 8:2:1 and subsequently dissolved in dichloromethane.

    Techniques: Immunofluorescence, Fluorescence, Flow Cytometry, Expressing