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htau  (MedChemExpress)


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    Structured Review

    MedChemExpress htau
    The alternating access and inhibition mechanism of TauT. Key helices involved in the conformational changes are colored and labeled. The intracellular and extracellular cavities are depicted by purple and yellow shadows, respectively. The movement of TM1a during the transition from the occluded to the inward-open state is indicated by an ash black arrow. Sodium and chloride ions are represented as purple and green spheres, respectively. Molecules of taurine, GABA, GAA, β-Ala, P4S, I4AA, <t>GES,</t> <t>5AVA,</t> <t>Htau</t> and nipecotic acid are represented as spheres. Red lines indicate that the small molecules block TauT in the current conformation.
    Htau, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/htau/product/MedChemExpress
    Average 94 stars, based on 4 article reviews
    htau - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "Molecular basis of human taurine transporter uptake and inhibition"

    Article Title: Molecular basis of human taurine transporter uptake and inhibition

    Journal: Nature Communications

    doi: 10.1038/s41467-025-62857-w

    The alternating access and inhibition mechanism of TauT. Key helices involved in the conformational changes are colored and labeled. The intracellular and extracellular cavities are depicted by purple and yellow shadows, respectively. The movement of TM1a during the transition from the occluded to the inward-open state is indicated by an ash black arrow. Sodium and chloride ions are represented as purple and green spheres, respectively. Molecules of taurine, GABA, GAA, β-Ala, P4S, I4AA, GES, 5AVA, Htau and nipecotic acid are represented as spheres. Red lines indicate that the small molecules block TauT in the current conformation.
    Figure Legend Snippet: The alternating access and inhibition mechanism of TauT. Key helices involved in the conformational changes are colored and labeled. The intracellular and extracellular cavities are depicted by purple and yellow shadows, respectively. The movement of TM1a during the transition from the occluded to the inward-open state is indicated by an ash black arrow. Sodium and chloride ions are represented as purple and green spheres, respectively. Molecules of taurine, GABA, GAA, β-Ala, P4S, I4AA, GES, 5AVA, Htau and nipecotic acid are represented as spheres. Red lines indicate that the small molecules block TauT in the current conformation.

    Techniques Used: Inhibition, Labeling, Blocking Assay



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    The alternating access and inhibition mechanism of TauT. Key helices involved in the conformational changes are colored and labeled. The intracellular and extracellular cavities are depicted by purple and yellow shadows, respectively. The movement of TM1a during the transition from the occluded to the inward-open state is indicated by an ash black arrow. Sodium and chloride ions are represented as purple and green spheres, respectively. Molecules of taurine, GABA, GAA, β-Ala, P4S, I4AA, <t>GES,</t> <t>5AVA,</t> <t>Htau</t> and nipecotic acid are represented as spheres. Red lines indicate that the small molecules block TauT in the current conformation.
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    The alternating access and inhibition mechanism of TauT. Key helices involved in the conformational changes are colored and labeled. The intracellular and extracellular cavities are depicted by purple and yellow shadows, respectively. The movement of TM1a during the transition from the occluded to the inward-open state is indicated by an ash black arrow. Sodium and chloride ions are represented as purple and green spheres, respectively. Molecules of taurine, GABA, GAA, β-Ala, P4S, I4AA, <t>GES,</t> <t>5AVA,</t> <t>Htau</t> and nipecotic acid are represented as spheres. Red lines indicate that the small molecules block TauT in the current conformation.
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    Image Search Results


    The alternating access and inhibition mechanism of TauT. Key helices involved in the conformational changes are colored and labeled. The intracellular and extracellular cavities are depicted by purple and yellow shadows, respectively. The movement of TM1a during the transition from the occluded to the inward-open state is indicated by an ash black arrow. Sodium and chloride ions are represented as purple and green spheres, respectively. Molecules of taurine, GABA, GAA, β-Ala, P4S, I4AA, GES, 5AVA, Htau and nipecotic acid are represented as spheres. Red lines indicate that the small molecules block TauT in the current conformation.

    Journal: Nature Communications

    Article Title: Molecular basis of human taurine transporter uptake and inhibition

    doi: 10.1038/s41467-025-62857-w

    Figure Lengend Snippet: The alternating access and inhibition mechanism of TauT. Key helices involved in the conformational changes are colored and labeled. The intracellular and extracellular cavities are depicted by purple and yellow shadows, respectively. The movement of TM1a during the transition from the occluded to the inward-open state is indicated by an ash black arrow. Sodium and chloride ions are represented as purple and green spheres, respectively. Molecules of taurine, GABA, GAA, β-Ala, P4S, I4AA, GES, 5AVA, Htau and nipecotic acid are represented as spheres. Red lines indicate that the small molecules block TauT in the current conformation.

    Article Snippet: For the inhibition assay, the cells were incubated in PBS containing 0.5 μCi/mL [ 3 H]taurine and 0.6 mM P4S (MedChemExpress), 0.8 mM I4AA (MedChemExpress), 3 mM GES (MedChemExpress), 1.5 mM 5AVA (MedChemExpress), 2 mM nipecotic acid (MedChemExpress) or 3.5 mM Htau (MedChemExpress).

    Techniques: Inhibition, Labeling, Blocking Assay