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azd5153  (MedChemExpress)


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    MedChemExpress azd5153
    Azd5153, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/azd5153/product/MedChemExpress
    Average 90 stars, based on 6 article reviews
    azd5153 - by Bioz Stars, 2026-02
    90/100 stars

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    DDR inhibitor drug screening in OC PDX models (A) Tumor volume change curves of OC09_OVPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5 for CON group, n = 6 for WEE1i and PARPi groups). (B) Tumor volume change curves of OC19_OVPF2 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5). (C) Tumor volume change curves of OC13_OVPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 6). (D) Tumor volume change curves of OC04_OVPF2 PDX subjected to WEE1i, PARPi, <t>BRD4/BETi,</t> and vehicle treatment ( n = 5 for CON and WEE1i groups, n = 4 for PARPi and <t>BRD4/BETi</t> groups). (E) Tumor volume change curves of OC21_OVPF5 PDX subjected to WEE1i, PARPi, ATMi, and vehicle treatment ( n = 5). (F) Tumor volume change curves of OC27_AFPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5). For (A)–(F), p values were calculated by t test.
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    DDR inhibitor drug screening in OC PDX models (A) Tumor volume change curves of OC09_OVPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5 for CON group, n = 6 for WEE1i and PARPi groups). (B) Tumor volume change curves of OC19_OVPF2 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5). (C) Tumor volume change curves of OC13_OVPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 6). (D) Tumor volume change curves of OC04_OVPF2 PDX subjected to WEE1i, PARPi, BRD4/BETi, and vehicle treatment ( n = 5 for CON and WEE1i groups, n = 4 for PARPi and BRD4/BETi groups). (E) Tumor volume change curves of OC21_OVPF5 PDX subjected to WEE1i, PARPi, ATMi, and vehicle treatment ( n = 5). (F) Tumor volume change curves of OC27_AFPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5). For (A)–(F), p values were calculated by t test.

    Journal: Cell Reports Medicine

    Article Title: Genomic profiling of a multi-lineage and multi-passage patient-derived xenograft biobank reflects heterogeneity of ovarian cancer

    doi: 10.1016/j.xcrm.2024.101631

    Figure Lengend Snippet: DDR inhibitor drug screening in OC PDX models (A) Tumor volume change curves of OC09_OVPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5 for CON group, n = 6 for WEE1i and PARPi groups). (B) Tumor volume change curves of OC19_OVPF2 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5). (C) Tumor volume change curves of OC13_OVPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 6). (D) Tumor volume change curves of OC04_OVPF2 PDX subjected to WEE1i, PARPi, BRD4/BETi, and vehicle treatment ( n = 5 for CON and WEE1i groups, n = 4 for PARPi and BRD4/BETi groups). (E) Tumor volume change curves of OC21_OVPF5 PDX subjected to WEE1i, PARPi, ATMi, and vehicle treatment ( n = 5). (F) Tumor volume change curves of OC27_AFPF3 PDX subjected to WEE1i, PARPi, and vehicle treatment ( n = 5). For (A)–(F), p values were calculated by t test.

    Article Snippet: BRD4 inhibitor , MedChemExpress , AZD5153.

    Techniques:

    Journal: Cell Reports Medicine

    Article Title: Genomic profiling of a multi-lineage and multi-passage patient-derived xenograft biobank reflects heterogeneity of ovarian cancer

    doi: 10.1016/j.xcrm.2024.101631

    Figure Lengend Snippet:

    Article Snippet: BRD4 inhibitor , MedChemExpress , AZD5153.

    Techniques: Recombinant, Saline, Sequencing, Software