tmpyp4 (Santa Cruz Biotechnology)
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93
Structured Review
Santa Cruz Biotechnology
tmpyp4
Tmpyp4, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tmpyp4/TMPyP4/pm38918043-195-0-2
Average 93 stars, based on 10 article reviews
Tmpyp4, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tmpyp4/TMPyP4/pm38918043-195-0-2
Average 93 stars, based on 10 article reviews
tmpyp4 - by Bioz Stars,
2026-10
93/100 stars
Images
1) Product Images from "Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis."
Article Title: Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis.
Journal: RNA (New York, N.Y.)
doi: 10.1261/rna.080043.124
Figure Legend Snippet: FIGURE 1. Inhibition of CST–PP activity by TMPyP4. (A) Representative gels showing C-strand synthesis on the 9xTEL template in NaCl/KCl (left) or LiCl (right) with trace amount of radiolabeled template (T) serving as recovery control. Twofold dilutions of TMPyP4 (highest concentration: 3200 nM) were incubated with the template before the addition of CST–PP and nucleotides. (B) Plot of relative synthesis intensities as a function of TMPyP4 concentration in NaCl/KCl or LiCl. Points represent mean values and error bars represent SD for n = 5 (Na+/K+) or n = 4 (Li+) indepen- dent experiments. (C,D) Same as panels A,B except that the template was 9xnoGG. For panel D, n = 4.
Techniques Used: Inhibition, Activity Assay, Control, Concentration Assay, Incubation
Figure Legend Snippet: FIGURE 2. TMPyP4 inhibits CST–PP binding to template DNA. (A) Representative gels of CST–PP binding to radiolabeled template DNA in NaCl/KCl (left) or LiCl (right) following incubation of DNA with increasing concentrations of TMPyP4 (twofold dilutions from 3200 nM). (T) Template, (T–P) template–protein complex, (W) well. (B) Plot of fraction DNA bound at each concentration of TMPyP4 normalized to fraction bound with no inhibitor in NaCl/KCl or LiCl. Points represent mean values and error bars represent SD for n = 6 independent experiments, except 9xnoGG in Li+ (n = 4).
Techniques Used: Binding Assay, Incubation, Concentration Assay
Figure Legend Snippet: FIGURE 4. (A) Native gel electrophoresis with 9xTEL DNA incubated with twofold dilutions of TMPyP4 (highest concentration: 3200 nM) in NaCl/KCl (left half of gel) or LiCl (right half). (B) As in panel A but with 9xnoGG DNA. (C) Native gel of 9xTEL DNA incubated with twofold dilutions of PDS (highest concentration: 1600 nM) in NaCl/KCl (left half) or LiCl (right half). (D) As in panel C but with 9xnoGG DNA.
Techniques Used: Nucleic Acid Electrophoresis, Incubation, Concentration Assay
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