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BioFocus DPI small molecule screening assay
Small Molecule Screening Assay, supplied by BioFocus DPI, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/throughput+screening/high+throughput+screening/pmc04871731-445-15-19
Average 90 stars, based on 1 article reviews
small molecule screening assay - by Bioz Stars, 2026-09
90/100 stars

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Article Title: In Brief
Article Snippet: On February 10, pharmaceutical giant Johnson & Johnson (J&J; New Brunswick, NJ) announced the purchase of biopharmaceutical firm Scios (Sunnyvale, CA) for $2.4 billion in an all-stock transaction.. Scios shareholders will receive $45 per share, a 30% premium on Scios’ February 7 share price, which rose 26% to $43.92 on the news.. J&J gets Scios’ Natrecor, a recombinant human B-type natriuretic peptide for congestive heart failure with annual sales expected to reach $160–170 million in 2003.

Article Title: Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-D-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC)
Article Snippet: Herein we report the high-throughput screen (HTS) of 201,368 compounds from the NIH Molecular Libraries Small Molecule Repository (BioFocus DPI) against Mycobacterium tuberculosis RmlC and RmlD in the same assay.

Article Title: Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding
Article Snippet: We thank Professor Peter Ratcliffe (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) for providing input and support and for providing us with Chinese hamster ovary HREluciferase–expressing cell lines, renal cancer cell lines RCC4 and 786-0, and pGL3-HRE PGK Luciferase constructs; BioFocus Discovery for carrying out the initial high-throughput screening; Dr. Raj Mehta (Cancer Research Technology, London, United Kingdom) for support; Professor Christopher Schofield (Department of Chemistry University of Oxford, Oxford, United Kingdom); and Dr. Tony Raynham (Head of the Medicinal Chemistry Group Cancer Research Technology) for their input on chemistry; and all members of Adrian Harris laboratory for their technical input and support.

Article Title: CONCENTRATES
Article Snippet: Three biotech firms announced restructuring plans and staff cuts last week.. QLT, which specializes in eye disease therapy, announced a plan to halt other drug development programs that could amount to a 46% reduction of its staff of 474.. Half the jobs will be eliminated in January; the rest may be cut through subsequent divestitures, according to Acting CEO Robert Butchofsky.

Article Title: Summary of Recent Deal Activity
Article Snippet: Abbott, Celera Genomics R&D agreement Two antigen targets discovered by Celera Genomics have been selected for further investigation by Abbott for therapeutic development.. These are the first targets to be selected for advancement in the strategic collaboration established in 2004.. Under the terms of the agreement, a number of protein antigens identified and validated by Celera Genomics are being screened by Abbott.

Screening Assay:

Article Title: A small molecule mitigates hearing loss in a mouse model of Usher syndrome III
Article Snippet: .. N.A.L. accommodated the small molecule screening assay at BioFocus; K.O. and F.J.A. conducted the small molecule screening assay at BioFocus; K.F.M., N.A.L., D.F.F., R.W.B., A.M.M. and W.E.H. provided project supervision at BioFocus. ..

Control:

Article Title: Screening assay for insecticides
Article Snippet: .. Sample control group averages from BioFocus compound screening showing first and second addition assay windows, and potential activator and antagonist profiles. .. Basic Test Protocol Cells were dispensed in a 50 μl volume containing 7,500 cells into 384-well TC clear/black assay plates (Greiner 781091) using a Multidrop 384 dispenser, incubated at ambient temperature for one hour (to reduce edge effects), and incubated overnight at 37° C./5% CO2.



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