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ccr5 antagonist maraviroc  (MedChemExpress)


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    MedChemExpress ccr5 antagonist maraviroc
    Ccr5 Antagonist Maraviroc, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rantes/RANTES%2FCCL5%2C+Human/pm42010652-46-31-34
    Average 93 stars, based on 4 article reviews
    ccr5 antagonist maraviroc - by Bioz Stars, 2026-10
    93/100 stars

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    Recombinant:

    Article Title: Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies ERK1/2 Antibody Abmart Cat# T40071; RRID: AB_2936996 Phospho-Erk1(T202/Y204) + Erk2 (T185/Y187) Antibody Abmart Cat# T40072; RRID: AB_2937019 Recombinant Anti-PDGFR Alpha antibody [EPR22059-270] Abcam Cat# ab203491; RRID: AB_2892065 Anti-GFP antibody [9F9.F9] Abcam Cat# ab1218; RRID: AB_298911 Anti-Green Fluorescent Protein Antibody Aves Labs Cat# GFP-1010; RRID: AB_2307313 Recombinant Anti-Iba1 antibody [EPR16588] Abcam Cat# ab178846; RRID: AB_2636859 Chicken Anti-GFAP Polyclonal Antibody Abcam Cat# ab4674; RRID: AB_304558 TCR beta Monoclonal Antibody (H57-597), PE Thermo Fisher Scientific Cat# A15408; RRID: AB_2534421 CD45.2 Monoclonal Antibody (104), APC, eBioscience Thermo Fisher Scientific Cat# 17-0454-82; RRID: AB_469400 Goat Anti-Rat IgG H&L (Alexa Fluor® 647) Abcam Cat# ab150167; RRID: AB_2864291 Anti-Rabbit IgG H&L (Alexa Fluor 555) Abcam Cat# ab150078; RRID: AB_2722519 Goat Anti-Chicken IgY H&L (Alexa Fluor® 647) Abcam Cat# ab150171; RRID: AB_2921318 Alexa Fluor 594-AffiniPure Donkey Anti-Chicken IgY (IgG) (H+L) Jackson ImmunoResearch Labs Cat# 703-585-155; RRID: AB_2340377 Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) Abcam Cat# ab150113; RRID: AB_2576208 Mouse CXCL10/IP-10/CRG-2 Antibody R&D Systems Cat# MAB466; RRID: AB_2292486 CXCL10 Polyclonal Antibody Thermo Fisher Scientific Cat# PA5-46999; RRID: AB_2609777 CXCL11 Monoclonal Antibody Thermo Fisher Scientific Cat# MA5-23761; RRID: AB_2610462 CXCL9 Polyclonal Antibody Thermo Fisher Scientific Cat# PA5-47020; RRID: AB_2609301 Mouse CXCL9/MIG Antibody R&D Systems Cat# AF-492-NA; RRID: AB_2086734 Bacterial and virus strains E. coli DH5α CoWin Biosciences CW0812S AAV2/9-CMV-LoX3-1.0-P2A-mCherry This paper N/A AAV2/9-CMV -LoX3-mut-P2A-mCherry This paper N/A AAV2/9-CMV –EGFP Vector core, CIBR BV01022 AAV2/9-EF1a-Cre Vector core, CIBR BV06001 AAV2/9-EF1a-EGFP Vector core, CIBR BV01019 AAV2/9-EF1a-mCherry Vector core, CIBR BV01020 AAV2/9-hSyn-jRGECO1a Vector core, CIBR BV04014 MSCV-LoX3-1.0 VectorBuilder (This paper) N/A MSCV-LoX3-mut VectorBuilder (This paper) N/A MSCV-EGFP VectorBuilder (This paper) N/A Chemicals, peptides, and recombinant proteins Lipopolysaccharide (LPS) Sigma L4130 Fluorescein Sigma 518-47-8 OVA peptide (257-264) QYAOBIO 138831-86-4 I-TAC/CXCL11 protein, Human (HEK293) MCE HY-P7228 (Continued on next page) e1 Immunity 58, 2320–2335.e1–e9, September 9, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER GRO-gamma/CXCL3 protein, Human (CHO) MCE HY-P7192 MIP-1 alpha/CCL3 protein, Human (CHO) MCE HY-P7254 I-309/CCL1 protein, Human (CHO) MCE HY-P7198 TARC/CCL17 protein, Human (HEK293, His) MCE HY-P7759 HCC-4/CCL16 protein, Human (CHO) MCE HY-P7196 MCP-3/CCL7 protein, Human (CHO) MCE HY-P7240 NAP-2/CXCL7 protein, Human (CHO) MCE HY-P7267 ENA-78/CXCL5 protein, Human (HEK293) MCE HY-P7157 RANTES/CCL5 protein, Human (HEK293) MCE HY-P7282 PF-4/CXCL4 protein, Human (HEK293, His) MCE HY-P70618 MIP-3 alpha/CCL20 protein, Human (CHO) MCE HY-P7260 GRO-alpha/CXCL1 protein, Human (HEK293, His) MCE HY-P70508 CCL24/Eotaxin-2 protein, Human (HEK293, His) MCE HY-P7766 MCP-2/CCL8 protein, Human (HEK293, His) MCE HY-P7770 HCC-1/CCL14 protein, Human (HEK293, His) MCE HY-P7763 MPIF-1/CCL23 protein, Human MCE HY-P7765 Recombinant CXCL10/IP-10 protein, Human Abcam ab280332 Recombinant CXCL10 (N-terminal truncated, 3-77), Human Novoprotein CXCTX-A Recombinant CXCL10 (C-terminal truncated, 1-73), Human Novoprotein CXCTX TAK-779 MCE HY-13406 BI-6901 MCE HY-116835 LMD-009 MCE HY-121885 VUF11207 fumarate MCE HY-110318 ML339 MCE HY-122197 Kynurenic acid MCE HY-100806 CCR7 ligand 1 (Cmp2105) MCE HY-133073 IL-17A protein, Human (HEK293, His) MCE HY-P70527 IL-18 protein, Human (HEK293, His) MCE HY-P70760 IL-12 protein, Human (HEK293) MCE HY-P7032 CCR2 antagonist 4 hydrochloride MCE HY-103362 IL-10 protein, Human (HEK293) MCE HY-P70751 IL-6 protein, Human (CHO) MCE HY-P7044A IFN-gamma protein, Human MCE HY-P7025 TNF-alpha/TNFSF2 Protein, Human MCE HY-P7058 IL-1 beta protein, Human MCE HY-P7028 Poly(I:C) MCE HY-107202 IFN-beta protein, Human (CHO) MCE HY-P73128 SB-265610 MCE HY-50688 ..

    Article Title: Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription
    Article Snippet: Prior to TGF‐β (2 ng/mL; #246‐LP‐025; R&D System, Minneapolis, MN, USA) stimulation, LX‐2 cells were subjected to an overnight serum starvation, which imitated HSC activation in vitro [ ]. .. During certain experiments, recombinant human CCL5 protein (20 ng/mL; #HY‐P7282, MedChemExpress) was added to DMEM with TGF‐β for 24 h. Primary human HSCs (H‐HSCs) were obtained from Lonza Bioscience (Walkersville, MD, USA) and maintained in the culture medium supplied by the vendor. ..

    Article Title: EGCG inhibits tobacco smoke-promoted proliferation of lung cancer cells through targeting CCL5.
    Article Snippet: Background: The occurrence and development of cancer are deeply intertwined with chronic inflammatory processes.. Epigallocatechin gallate (EGCG), the most pharmacologically potent catechin derived from tea, has garnered attention for its anti-inflammatory and anti-carcinogenic properties.. However, the molecular mechanisms through which EGCG modulates tobacco smoke (TS)-induced inflammatory responses in lung carcinogenesis remain incompletely elucidated.

    Article Title: Nuclear Factor I-B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription.
    Article Snippet: Prior to TGF- β (2 ng/mL; #246-LP-025; R&D System, Minneapolis, MN, USA) stimulation, LX-2 cells were subjected to an overnight serum starvation, which imitated HSC activation in vitro [ 48 ]. .. During certain experiments, recombinant human CCL5 protein (20 ng/mL; #HY-P7282, MedChemExpress) was added to DMEM with TGF- β for 24 h. Primary human HSCs (HHSCs) were obtained from Lonza Bioscience (Walkersville, MD, USA) and maintained in the culture medium supplied by the vendor. ..

    Laser Capture Microdissection:

    Article Title: Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies ERK1/2 Antibody Abmart Cat# T40071; RRID: AB_2936996 Phospho-Erk1(T202/Y204) + Erk2 (T185/Y187) Antibody Abmart Cat# T40072; RRID: AB_2937019 Recombinant Anti-PDGFR Alpha antibody [EPR22059-270] Abcam Cat# ab203491; RRID: AB_2892065 Anti-GFP antibody [9F9.F9] Abcam Cat# ab1218; RRID: AB_298911 Anti-Green Fluorescent Protein Antibody Aves Labs Cat# GFP-1010; RRID: AB_2307313 Recombinant Anti-Iba1 antibody [EPR16588] Abcam Cat# ab178846; RRID: AB_2636859 Chicken Anti-GFAP Polyclonal Antibody Abcam Cat# ab4674; RRID: AB_304558 TCR beta Monoclonal Antibody (H57-597), PE Thermo Fisher Scientific Cat# A15408; RRID: AB_2534421 CD45.2 Monoclonal Antibody (104), APC, eBioscience Thermo Fisher Scientific Cat# 17-0454-82; RRID: AB_469400 Goat Anti-Rat IgG H&L (Alexa Fluor® 647) Abcam Cat# ab150167; RRID: AB_2864291 Anti-Rabbit IgG H&L (Alexa Fluor 555) Abcam Cat# ab150078; RRID: AB_2722519 Goat Anti-Chicken IgY H&L (Alexa Fluor® 647) Abcam Cat# ab150171; RRID: AB_2921318 Alexa Fluor 594-AffiniPure Donkey Anti-Chicken IgY (IgG) (H+L) Jackson ImmunoResearch Labs Cat# 703-585-155; RRID: AB_2340377 Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) Abcam Cat# ab150113; RRID: AB_2576208 Mouse CXCL10/IP-10/CRG-2 Antibody R&D Systems Cat# MAB466; RRID: AB_2292486 CXCL10 Polyclonal Antibody Thermo Fisher Scientific Cat# PA5-46999; RRID: AB_2609777 CXCL11 Monoclonal Antibody Thermo Fisher Scientific Cat# MA5-23761; RRID: AB_2610462 CXCL9 Polyclonal Antibody Thermo Fisher Scientific Cat# PA5-47020; RRID: AB_2609301 Mouse CXCL9/MIG Antibody R&D Systems Cat# AF-492-NA; RRID: AB_2086734 Bacterial and virus strains E. coli DH5α CoWin Biosciences CW0812S AAV2/9-CMV-LoX3-1.0-P2A-mCherry This paper N/A AAV2/9-CMV -LoX3-mut-P2A-mCherry This paper N/A AAV2/9-CMV –EGFP Vector core, CIBR BV01022 AAV2/9-EF1a-Cre Vector core, CIBR BV06001 AAV2/9-EF1a-EGFP Vector core, CIBR BV01019 AAV2/9-EF1a-mCherry Vector core, CIBR BV01020 AAV2/9-hSyn-jRGECO1a Vector core, CIBR BV04014 MSCV-LoX3-1.0 VectorBuilder (This paper) N/A MSCV-LoX3-mut VectorBuilder (This paper) N/A MSCV-EGFP VectorBuilder (This paper) N/A Chemicals, peptides, and recombinant proteins Lipopolysaccharide (LPS) Sigma L4130 Fluorescein Sigma 518-47-8 OVA peptide (257-264) QYAOBIO 138831-86-4 I-TAC/CXCL11 protein, Human (HEK293) MCE HY-P7228 (Continued on next page) e1 Immunity 58, 2320–2335.e1–e9, September 9, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER GRO-gamma/CXCL3 protein, Human (CHO) MCE HY-P7192 MIP-1 alpha/CCL3 protein, Human (CHO) MCE HY-P7254 I-309/CCL1 protein, Human (CHO) MCE HY-P7198 TARC/CCL17 protein, Human (HEK293, His) MCE HY-P7759 HCC-4/CCL16 protein, Human (CHO) MCE HY-P7196 MCP-3/CCL7 protein, Human (CHO) MCE HY-P7240 NAP-2/CXCL7 protein, Human (CHO) MCE HY-P7267 ENA-78/CXCL5 protein, Human (HEK293) MCE HY-P7157 RANTES/CCL5 protein, Human (HEK293) MCE HY-P7282 PF-4/CXCL4 protein, Human (HEK293, His) MCE HY-P70618 MIP-3 alpha/CCL20 protein, Human (CHO) MCE HY-P7260 GRO-alpha/CXCL1 protein, Human (HEK293, His) MCE HY-P70508 CCL24/Eotaxin-2 protein, Human (HEK293, His) MCE HY-P7766 MCP-2/CCL8 protein, Human (HEK293, His) MCE HY-P7770 HCC-1/CCL14 protein, Human (HEK293, His) MCE HY-P7763 MPIF-1/CCL23 protein, Human MCE HY-P7765 Recombinant CXCL10/IP-10 protein, Human Abcam ab280332 Recombinant CXCL10 (N-terminal truncated, 3-77), Human Novoprotein CXCTX-A Recombinant CXCL10 (C-terminal truncated, 1-73), Human Novoprotein CXCTX TAK-779 MCE HY-13406 BI-6901 MCE HY-116835 LMD-009 MCE HY-121885 VUF11207 fumarate MCE HY-110318 ML339 MCE HY-122197 Kynurenic acid MCE HY-100806 CCR7 ligand 1 (Cmp2105) MCE HY-133073 IL-17A protein, Human (HEK293, His) MCE HY-P70527 IL-18 protein, Human (HEK293, His) MCE HY-P70760 IL-12 protein, Human (HEK293) MCE HY-P7032 CCR2 antagonist 4 hydrochloride MCE HY-103362 IL-10 protein, Human (HEK293) MCE HY-P70751 IL-6 protein, Human (CHO) MCE HY-P7044A IFN-gamma protein, Human MCE HY-P7025 TNF-alpha/TNFSF2 Protein, Human MCE HY-P7058 IL-1 beta protein, Human MCE HY-P7028 Poly(I:C) MCE HY-107202 IFN-beta protein, Human (CHO) MCE HY-P73128 SB-265610 MCE HY-50688 ..

    Protein-Protein interactions:

    Article Title: Targeting the CCL5/CCR5-PI3K-AKT axis suppresses hepatic stellate cell-induced breast cancer metastasis
    Article Snippet: All cell lines were maintained in a 37 °C, 5% CO 2 incubator (HeracellTM Vios 160i CR CO 2 incubator, 51033770, Thermo ScientificTM, Germany). .. To investigate the impact of the CCL5, CCR5, and PI3K-AKT signaling pathways on BC cells, during the cell culture process, cells were treated with 10 ng/ml CCL5 (MCE, HY-P7282), 100 nM CCR5 antagonist Maraviroc (MCE, HY-13004), and 500 nM of the PI3K inhibitor BKM120 (MCE, HY-70063) were added to the culture medium [ ]. .. A lentiviral short hairpin RNA (shRNA) interference vector (pSIH1-H1-copGFP; SH-, SI501A-1; System Biosciences, USA) was used to generate CCL5 knockdown constructs.

    Article Title: Targeting the CCL5/CCR5-PI3K-AKT axis suppresses hepatic stellate cell-induced breast cancer metastasis.
    Article Snippet: All cell lines were maintained in a 37°C, 5% CO2 incubator (HeracellTM Vios 160i CR CO2 incubator, 51033770, Thermo ScientificTM, Germany). .. To investigate the impact of the CCL5, CCR5, and PI3K-AKT signaling pathways on BC cells, during the cell culture process, cells were treated with 10 ng/ml CCL5 (MCE, HY-P7282), 100 nM CCR5 antagonist Maraviroc (MCE, HY-13004), and 500 nM of the PI3K inhibitor BKM120 (MCE, HY-70063) were added to the culture medium [14]. .. A lentiviral short hairpin RNA (shRNA) interference vector (pSIH1-H1-copGFP; SH-, SI501A-1; System Biosciences, USA) was used to generate CCL5 knockdown constructs.

    Cell Culture:

    Article Title: Targeting the CCL5/CCR5-PI3K-AKT axis suppresses hepatic stellate cell-induced breast cancer metastasis
    Article Snippet: All cell lines were maintained in a 37 °C, 5% CO 2 incubator (HeracellTM Vios 160i CR CO 2 incubator, 51033770, Thermo ScientificTM, Germany). .. To investigate the impact of the CCL5, CCR5, and PI3K-AKT signaling pathways on BC cells, during the cell culture process, cells were treated with 10 ng/ml CCL5 (MCE, HY-P7282), 100 nM CCR5 antagonist Maraviroc (MCE, HY-13004), and 500 nM of the PI3K inhibitor BKM120 (MCE, HY-70063) were added to the culture medium [ ]. .. A lentiviral short hairpin RNA (shRNA) interference vector (pSIH1-H1-copGFP; SH-, SI501A-1; System Biosciences, USA) was used to generate CCL5 knockdown constructs.

    Article Title: Targeting the CCL5/CCR5-PI3K-AKT axis suppresses hepatic stellate cell-induced breast cancer metastasis.
    Article Snippet: All cell lines were maintained in a 37°C, 5% CO2 incubator (HeracellTM Vios 160i CR CO2 incubator, 51033770, Thermo ScientificTM, Germany). .. To investigate the impact of the CCL5, CCR5, and PI3K-AKT signaling pathways on BC cells, during the cell culture process, cells were treated with 10 ng/ml CCL5 (MCE, HY-P7282), 100 nM CCR5 antagonist Maraviroc (MCE, HY-13004), and 500 nM of the PI3K inhibitor BKM120 (MCE, HY-70063) were added to the culture medium [14]. .. A lentiviral short hairpin RNA (shRNA) interference vector (pSIH1-H1-copGFP; SH-, SI501A-1; System Biosciences, USA) was used to generate CCL5 knockdown constructs.



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    Image Search Results


    Influence of LX-2 Cells on MDA-MB-231 Cells through CCL5. Note: ( A ) Schematic representation of the cell experiment process; ( B ) CCK-8 experiment assessing changes in cell proliferation in each group; 100 µL of conditioned medium (CM) per well; ( C ) Scratch assay examining cell migration ability in each group with statistical analysis (scale bar: 100 μm); 2 mL of CM per well; ( D ) Transwell assay measuring cell invasion ability in each group (scale bar: 50 μm); 200 µL of CM per well; ( E ) WB analysis of EMT marker proteins E-cadherin, N-cadherin, and Vimentin, and PI3K-AKT pathway protein expression changes; 2 mL of CM per well. CM: condition medium.* P < 0.05, with all cell experiments repeated three times

    Journal: Cancer Cell International

    Article Title: Targeting the CCL5/CCR5-PI3K-AKT axis suppresses hepatic stellate cell-induced breast cancer metastasis

    doi: 10.1186/s12935-026-04295-2

    Figure Lengend Snippet: Influence of LX-2 Cells on MDA-MB-231 Cells through CCL5. Note: ( A ) Schematic representation of the cell experiment process; ( B ) CCK-8 experiment assessing changes in cell proliferation in each group; 100 µL of conditioned medium (CM) per well; ( C ) Scratch assay examining cell migration ability in each group with statistical analysis (scale bar: 100 μm); 2 mL of CM per well; ( D ) Transwell assay measuring cell invasion ability in each group (scale bar: 50 μm); 200 µL of CM per well; ( E ) WB analysis of EMT marker proteins E-cadherin, N-cadherin, and Vimentin, and PI3K-AKT pathway protein expression changes; 2 mL of CM per well. CM: condition medium.* P < 0.05, with all cell experiments repeated three times

    Article Snippet: To investigate the impact of the CCL5, CCR5, and PI3K-AKT signaling pathways on BC cells, during the cell culture process, cells were treated with 10 ng/ml CCL5 (MCE, HY-P7282), 100 nM CCR5 antagonist Maraviroc (MCE, HY-13004), and 500 nM of the PI3K inhibitor BKM120 (MCE, HY-70063) were added to the culture medium [ ].

    Techniques: CCK-8 Assay, Wound Healing Assay, Migration, Transwell Assay, Marker, Expressing

    Impact of CCR5 and PI3K-AKT Pathway Inhibition on MDA-MB-231 Cells. Note: ( A ) CCK-8 experiment evaluating changes in cell proliferation in each group; ( B ) Scratch assay assessing cell migration ability in each group with statistical representation (scale bar: 100 μm); ( C ) Transwell assay measuring cell invasion ability in each group (scale bar: 50 μm); ( D ) WB analysis of EMT marker proteins E-cadherin, N-cadherin, and Vimentin, and PI3K-AKT pathway protein expression changes. * P < 0.05, with all cell experiments repeated three times

    Journal: Cancer Cell International

    Article Title: Targeting the CCL5/CCR5-PI3K-AKT axis suppresses hepatic stellate cell-induced breast cancer metastasis

    doi: 10.1186/s12935-026-04295-2

    Figure Lengend Snippet: Impact of CCR5 and PI3K-AKT Pathway Inhibition on MDA-MB-231 Cells. Note: ( A ) CCK-8 experiment evaluating changes in cell proliferation in each group; ( B ) Scratch assay assessing cell migration ability in each group with statistical representation (scale bar: 100 μm); ( C ) Transwell assay measuring cell invasion ability in each group (scale bar: 50 μm); ( D ) WB analysis of EMT marker proteins E-cadherin, N-cadherin, and Vimentin, and PI3K-AKT pathway protein expression changes. * P < 0.05, with all cell experiments repeated three times

    Article Snippet: To investigate the impact of the CCL5, CCR5, and PI3K-AKT signaling pathways on BC cells, during the cell culture process, cells were treated with 10 ng/ml CCL5 (MCE, HY-P7282), 100 nM CCR5 antagonist Maraviroc (MCE, HY-13004), and 500 nM of the PI3K inhibitor BKM120 (MCE, HY-70063) were added to the culture medium [ ].

    Techniques: Inhibition, CCK-8 Assay, Wound Healing Assay, Migration, Transwell Assay, Marker, Expressing

    CCL5 Derived from HSCs Activates the PI3K-AKT Pathway through the CCL5/CCR5 Axis to Promote the Invasion and Metastasis of Breast Cancer Cells

    Journal: Cancer Cell International

    Article Title: Targeting the CCL5/CCR5-PI3K-AKT axis suppresses hepatic stellate cell-induced breast cancer metastasis

    doi: 10.1186/s12935-026-04295-2

    Figure Lengend Snippet: CCL5 Derived from HSCs Activates the PI3K-AKT Pathway through the CCL5/CCR5 Axis to Promote the Invasion and Metastasis of Breast Cancer Cells

    Article Snippet: To investigate the impact of the CCL5, CCR5, and PI3K-AKT signaling pathways on BC cells, during the cell culture process, cells were treated with 10 ng/ml CCL5 (MCE, HY-P7282), 100 nM CCR5 antagonist Maraviroc (MCE, HY-13004), and 500 nM of the PI3K inhibitor BKM120 (MCE, HY-70063) were added to the culture medium [ ].

    Techniques: Derivative Assay