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impact i pathogen test  (IDEXX)


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    Structured Review

    IDEXX impact i pathogen test
    Impact I Pathogen Test, supplied by IDEXX, used in various techniques. Bioz Stars score: 96/100, based on 291 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pathogen+testing/IMPACT/us12706227-1150-13-17
    Average 96 stars, based on 291 article reviews
    impact i pathogen test - by Bioz Stars, 2026-10
    96/100 stars

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    Related Articles

    other:

    Article Title: IgM promotes antitumor immunity to a Tn-expressing solid tumor.
    Article Snippet: CMT93 and CMT93- Cosmc− cells were tested for Mycoplasma and rodent pathogens (IMPACT IV testing, IDEXX- RADIL) prior to expansion and aliquot freeze- down for use in mice.

    Article Title: Simulation-guided non-thermal low-intensity ultrasound reprograms the tumor immune microenvironment and engages systemic antitumor immunity in a syngeneic orthotopic mouse model of breast cancer
    Article Snippet: Cells tested negative for mycoplasma and mouse pathogens (IMPACT II Test, IDEXX Bioanalytics, Westbrook, USA) and were used in passages 3-4.

    Article Title: PSMA binding of carbamate-containing peptidomimetics influenced by side chain length and stereocenter configuration in preclinical prostate cancer model.
    Article Snippet: To explore how core backbone modifications influence prostate-specific membrane antigen (PSMA) targeting, we synthesized a series of novel peptidomimetics replacing the classic urea linkage of established radiotracers with a carbamate functionality.. This panel systematically varied side chain length (aspartic vs. aminoadipic acid), stereocenter configuration (S/S vs. S/R diastereomers), and the radiometal chelator (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid [DOTA] vs. N,N′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′diacetic acid [HBED-CC]).. In vitro binding assays in LNCaP cells revealed that the carbamate backbone severely compromised PSMA affinity (Ki) for short-chain aspartic acid derivatives, whereas long-chain aminoadipic acid conjugates successfully retained low-nanomolar potencies.

    Article Title: Methods and compositions for treating cancer with von Willebrand factor peptide linked to immunotherapeutic antibodies
    Article Snippet: All cell lines used in this study were checked for mycoplasma contamination by IMPACT I pathogen test (IDEXX BioResearch).

    Polymerase Chain Reaction:

    Article Title: Methods and compositions for treating cancer with cancer-targeted adjuvants
    Article Snippet: SDS-PAGE was performed on 4-20% gradient gels (Bio-Rad) using antibody of a standard curve (2, 1.5, 1, and 0.5 mg/mL) and two dilutions of antibody-pManTLR7 conjugate samples were reduced with 10 mM dithiothreitol. .. All cell lines were tested to confirm a lack of murine pathogens via IMPACT I PCR testing (IDEXX Laboratories). .. Band density of reduced sample and antibody standard curve was then analyzed using ImageJ and antibody concentration of sample was calculated based on intensity, using standard curve generated.

    Article Title: Coordinated immune activation following KRAS inhibition in syngeneic models reveals molecular pathways that potentiate and limit antitumor immunity
    Article Snippet: .. Cell authentication and screening for rodent pathogens and mycoplasma were performed by IDEXX BioAnalytics using the IMPACT VIII PCR Profile and CellCheck mouse STR profile. ..

    Cell Culture:

    Article Title: Four new mouse models of Duchenne muscular dystrophy with clinically relevant exon deletions in the human DMD gene
    Article Snippet: .. ES cells were cultured in a laboratory utilizing materials that passed the ‘IMPACT 2’ mouse pathogen test (IDEXX BioAnalytix). ..

    In Vivo:

    Article Title: Systematic Evaluation of Combination Strategies with Rezatapopt in p53 Y220C–Mutant Cancer Models
    Article Snippet: Mycoplasma testing was 138 performed using the Universal Mycoplasma Detection Kit (ATCC, Cat. # 30-1012K), following the 139 manufacturer’s instructions. .. Prior to in vivo use, cell lines were additionally tested for 140 pathogens at IDEXX (IMPACT MR Test). ..

    Screening:

    Article Title: Coordinated immune activation following KRAS inhibition in syngeneic models reveals molecular pathways that potentiate and limit antitumor immunity
    Article Snippet: .. Cell authentication and screening for rodent pathogens and mycoplasma were performed by IDEXX BioAnalytics using the IMPACT VIII PCR Profile and CellCheck mouse STR profile. ..



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    Flow diagram depicting patient and sample selection for the comparison of BAL fluid mcfDNA sequencing with the <t>Karius®</t> <t>test</t> and standard of care testing.
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    Image Search Results


    Flow diagram depicting patient and sample selection for the comparison of BAL fluid mcfDNA sequencing with the Karius® test and standard of care testing.

    Journal: medRxiv

    Article Title: Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia

    doi: 10.1101/2025.11.05.25339543

    Figure Lengend Snippet: Flow diagram depicting patient and sample selection for the comparison of BAL fluid mcfDNA sequencing with the Karius® test and standard of care testing.

    Article Snippet: Karius® Test Pathogen Categories: The operating characteristics of the Karius® BAL test have recently been submitted for publication.

    Techniques: Selection, Comparison, Sequencing

    Additive diagnostic value of BAL fluid mcfDNA sequencing with the Karius® test (KT-BAL) compared to standard of care (SOC) testing in immunocompromised patients with pneumonia. A) Number of organisms across all samples identified by either SOC alone, KT-BAL alone, or both techniques, split by KT-BAL category. B) Organisms identified exclusively by KT-BAL across all samples, split by KT-BAL category.

    Journal: medRxiv

    Article Title: Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia

    doi: 10.1101/2025.11.05.25339543

    Figure Lengend Snippet: Additive diagnostic value of BAL fluid mcfDNA sequencing with the Karius® test (KT-BAL) compared to standard of care (SOC) testing in immunocompromised patients with pneumonia. A) Number of organisms across all samples identified by either SOC alone, KT-BAL alone, or both techniques, split by KT-BAL category. B) Organisms identified exclusively by KT-BAL across all samples, split by KT-BAL category.

    Article Snippet: Karius® Test Pathogen Categories: The operating characteristics of the Karius® BAL test have recently been submitted for publication.

    Techniques: Diagnostic Assay, Sequencing

    Analysis of microbial read and human read values reported by the BAL fluid Karius® test (KT-BAL). A) Organisms that are identified in at least five samples by both KT-BAL and standard of care (SOC) testing and in at least five other samples by only KT-BAL have significantly lower microbial read values in the SOC + KT-BAL samples (Mann-Whitney U test, FDR < 0.05). B) KT-BAL microbial read values strongly correlate with culture quantities from SOC (Spearman’s rank correlation). C) KT-BAL human read values do not correlate with markers of host immune response (Spearman’s rank correlation).

    Journal: medRxiv

    Article Title: Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia

    doi: 10.1101/2025.11.05.25339543

    Figure Lengend Snippet: Analysis of microbial read and human read values reported by the BAL fluid Karius® test (KT-BAL). A) Organisms that are identified in at least five samples by both KT-BAL and standard of care (SOC) testing and in at least five other samples by only KT-BAL have significantly lower microbial read values in the SOC + KT-BAL samples (Mann-Whitney U test, FDR < 0.05). B) KT-BAL microbial read values strongly correlate with culture quantities from SOC (Spearman’s rank correlation). C) KT-BAL human read values do not correlate with markers of host immune response (Spearman’s rank correlation).

    Article Snippet: Karius® Test Pathogen Categories: The operating characteristics of the Karius® BAL test have recently been submitted for publication.

    Techniques: MANN-WHITNEY

    Patients for whom BAL fluid mcfDNA testing with the Karius® test (KT-BAL) identified Category One or Two organisms missed by standard of care (SOC) had significantly more cumulative intubation days compared to patients where KT-BAL and SOC were concordant for all Category One or Two organisms. Hospital length of stay, ICU length of stay, and ICU mortality were worse in the KT-BAL only group, but these differences were not significant (Mann-Whitney U test for continuous variables, Fisher’s exact test for mortality).

    Journal: medRxiv

    Article Title: Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia

    doi: 10.1101/2025.11.05.25339543

    Figure Lengend Snippet: Patients for whom BAL fluid mcfDNA testing with the Karius® test (KT-BAL) identified Category One or Two organisms missed by standard of care (SOC) had significantly more cumulative intubation days compared to patients where KT-BAL and SOC were concordant for all Category One or Two organisms. Hospital length of stay, ICU length of stay, and ICU mortality were worse in the KT-BAL only group, but these differences were not significant (Mann-Whitney U test for continuous variables, Fisher’s exact test for mortality).

    Article Snippet: Karius® Test Pathogen Categories: The operating characteristics of the Karius® BAL test have recently been submitted for publication.

    Techniques: MANN-WHITNEY