p21 (Santa Cruz Biotechnology)
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Santa Cruz Biotechnology
p21
P21, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 5694 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p21/p21/pm42883685-261-109-141
Average 96 stars, based on 5694 article reviews
P21, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 5694 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/p21/p21/pm42883685-261-109-141
Average 96 stars, based on 5694 article reviews
p21 - by Bioz Stars,
2026-10
96/100 stars
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Staining:Article Title: Capsaicin Induces G2/M Cell-Cycle Arrest and Impairs Autophagy in Caco-2 Cells: An Exploratory Study. Article Snippet: .. Membranes were then stained with Ponceau S to verify protein transfer, blocked with 5% milk in TBST (0.1% Tween-20) for 1 h, and https://doi.org/10.3390/ijms27198435 incubated overnight at 4 ◦C with primary antibodies against LC3B (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 43566S, Lot No. 14; dilution 1:1000), cathepsin-D (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 2284S, Lot No. 2; dilution 1:1000), occludin (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 91131S, Lot No. 3; dilution 1:1000), PARP (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 9542S, Lot No. 15; dilution 1:1000), cleaved caspase-3 (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 9661S, Lot No. 43; dilution 1:1000), Incubation:Article Title: Capsaicin Induces G2/M Cell-Cycle Arrest and Impairs Autophagy in Caco-2 Cells: An Exploratory Study. Article Snippet: .. Membranes were then stained with Ponceau S to verify protein transfer, blocked with 5% milk in TBST (0.1% Tween-20) for 1 h, and https://doi.org/10.3390/ijms27198435 incubated overnight at 4 ◦C with primary antibodies against LC3B (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 43566S, Lot No. 14; dilution 1:1000), cathepsin-D (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 2284S, Lot No. 2; dilution 1:1000), occludin (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 91131S, Lot No. 3; dilution 1:1000), PARP (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 9542S, Lot No. 15; dilution 1:1000), cleaved caspase-3 (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 9661S, Lot No. 43; dilution 1:1000), Article Title: New C-30 secondary and tertiary amines of betulin with selective antiproliferative activity toward hematological malignancies - Synthesis and biological evaluation Article Snippet: .. Blots were incubated overnight at 4 ◦C with primary antibodies directed against proteins involved in DNA damage response, cell-cycle regulation, and apoptosis, including γH2AX (Novus Biologicals); PCNA, Chk1, Cyclin E1, and Cell-Signaling:Article Title: Capsaicin Induces G2/M Cell-Cycle Arrest and Impairs Autophagy in Caco-2 Cells: An Exploratory Study. Article Snippet: .. Membranes were then stained with Ponceau S to verify protein transfer, blocked with 5% milk in TBST (0.1% Tween-20) for 1 h, and https://doi.org/10.3390/ijms27198435 incubated overnight at 4 ◦C with primary antibodies against LC3B (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 43566S, Lot No. 14; dilution 1:1000), cathepsin-D (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 2284S, Lot No. 2; dilution 1:1000), occludin (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 91131S, Lot No. 3; dilution 1:1000), PARP (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 9542S, Lot No. 15; dilution 1:1000), cleaved caspase-3 (Cell Signaling Technology, Danvers, MA, USA; Cat. No. 9661S, Lot No. 43; dilution 1:1000), Article Title: New C-30 secondary and tertiary amines of betulin with selective antiproliferative activity toward hematological malignancies - Synthesis and biological evaluation Article Snippet: .. Blots were incubated overnight at 4 ◦C with primary antibodies directed against proteins involved in DNA damage response, cell-cycle regulation, and apoptosis, including γH2AX (Novus Biologicals); PCNA, Chk1, Cyclin E1, and Article Title: CDK4/6i Reverses MEIS2 Inhibition of CRL4CRBN and Promotes BCMA Loss to Enhance IMiD/CELMoD Therapy in Multiple Myeloma Article Snippet: .. 160 Immunoblotting 161 Immunoblotting was performed20 using antibodies against phosphorylated Rb (Ser807/811), Rb, 162 CDK4, cleaved caspase-3, IKZF1 and BCMA (Cell Signaling Technology); actin (BD 163 Biosciences); CDK6, cyclin A, cyclin E, Article Title: Targeting p53/p21 Signaling: Linarin as a Novel Modulator of 5-FU Sensitization in Colorectal Cancer Article Snippet: Pifithrin-α (p53 inhibitor) and UC2288 (p21 inhibitor) were purchased from Selleck Chemicals (Houston, TX, USA). .. Primary antibodies against p53 (DO-1), Western Blot:Article Title: CDK4/6i Reverses MEIS2 Inhibition of CRL4CRBN and Promotes BCMA Loss to Enhance IMiD/CELMoD Therapy in Multiple Myeloma Article Snippet: .. 160 Immunoblotting 161 Immunoblotting was performed20 using antibodies against phosphorylated Rb (Ser807/811), Rb, 162 CDK4, cleaved caspase-3, IKZF1 and BCMA (Cell Signaling Technology); actin (BD 163 Biosciences); CDK6, cyclin A, cyclin E, |
![( A ) MCF7-PALR and MCF7-ABER cells were treated with Ctr-ASO-M or SUV-ASO-Ms (0.1 μM). CCK8 assays reveal the cell growth under PAL (0.5 μM) or ABE (0.1 μM) treatment ( N = 3 biological replicates). ( B ) CCK8 assays calculating IC 50 values of SUV-ASO-Ms in MCF7-TAMR, MCF7-PALR, and MCF7-ABER cells ( N = 3 biological replicates). ( C ) Synergy Finder is calculating ZIP scores in MCF7-TAMR to study the synergistic effect between SUV-ASO-Ms and CDK4/6i (PAL and ABE). ( D and E ) MCF7-PALR and MCF7-ABER cells were treated with Ctr-ASO-M or SUV-ASO-Ms (0.1 μM) alone or in combination with CDK4/6i (PAL, 0.5 μM and ABE, 0.1 μM). Flow cytometry analysis (D) and β-Gal activity assays (20× magnification) (E) showing the cell cycle distribution and senescence of the cells. ( F ) Schematic depicting the experimental design of the MCF7-ABER xenograft tumors conducted to assess the efficacy of SUV-ASO2-M or a combination of SUV-ASO2-M with ABE in vivo. ( G to I ) After being treated with Ctr-ASO-M or SUV-ASO2-M in combination with Veh or ABE, the tumor growth curves (G), the harvested tumors (H), and the tumor weight (I) were measured. ( J and K ) RT-qPCR and Western blotting detection of SUV39H2 mRNA (J) and protein (K) in tumors from xenografts. ( L ) IHC staining of <t>p21</t> in tumors from xenografts. H scores were calculated for p21 in all samples. Data were presented as means ± SD [(A to E), N = 3 biological replicates; (G), (I), (J) to (L), N = 5 biological replicates]. The P values were calculated by one-way ANOVA followed by Tukey’s test for multiple-group comparison.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_1863/pmc13651863/pmc13651863__sciadv.aea2001-f4.jpg)
