make receptor graphical utility (OpenEye Scientific Software Inc)
90
Structured Review
OpenEye Scientific Software Inc
make receptor graphical utility
Make Receptor Graphical Utility, supplied by OpenEye Scientific Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/make_receptor+graphical+utility/make+receptor+function/pm31785857-252-5-16
Average 90 stars, based on 1 article reviews
Make Receptor Graphical Utility, supplied by OpenEye Scientific Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/make_receptor+graphical+utility/make+receptor+function/pm31785857-252-5-16
Average 90 stars, based on 1 article reviews
make receptor graphical utility - by Bioz Stars,
2026-09
90/100 stars
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Selection:Article Title: Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. Article Snippet: In particular, the 3EQM PDB complex was selected as a representative structure of CYP19A1 due to the unavailability of complexes of this target with nonsteroidal ligands, and because of its higher resolution (i.e. 2.9 Å).59 4FDH51 and 6M7X49 PDB complexes were selected as representatives of the CYP11B2 and CYP11B1 enzymes, respectively, as they have been cocrystallized with (R)-fadrozole (PDB ID: 4FDH; PDB ligand ID: 0T3) and (S)-fadrozole (PDB ID: 6M7X; PDB ligand ID: JTD), which emerged in the similarity estimations; the selection of these structures is in line with good practices of structure-based multitarget drug design.70,71 The selected structures were first prepared for docking by using default parameters via the Protein Preparation Wizard utility (Schrödinger).72 Receptor grids were generated by means of the Article Title: Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway. Article Snippet: Colorectal cancer (CRC), among the most aggressive and prevailing neoplasms, is primarily treated with chemotherapy.. Voacamine (VOA), a novel bisindole natural product, possesses a variety of conspicuous pharmacological activities.. Within the current research, we evaluated in vitro and in vivo the anticancer efficacy of VOA against CRC and its potential mechanisms. Article Title: Identification of the potential biological target of N -benzenesulfonyl-1,2,3,4-tetrahydroquinoline compounds active against gram-positive and gram-negative bacteria. Article Snippet: The development of new antibiotics with activity towards a broad spectrum of bacteria, including multiresistant strains, is a very important topic for global public health.. As part of previous works, N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline (BSTHQ) derivatives were described as antimicrobial agents active against Gram-positive and Gram-negative pathogens.. In this work, experimental and molecular modelling studies were performed in order to identify their potential biological target in the light of structure-based design efforts towards further BSTHQ derivatives. Article Title: Molecular Dynamics Simulations Identify Tractable Lead-like Phenyl-Piperazine Scaffolds as eIF4A1 ATP-competitive Inhibitors Article Snippet: Receptor docking grids were generated for virtual screening with Glide Receptor Grid Generation (Schrödinger Release 2019-3: Glide, Schrödinger, LLC, New York, NY, 2019) and OpenEye’s Article Title: AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK Article Snippet: Receptor docking grids were generated for virtual screening with Article Title: AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK. Article Snippet: Receptor docking grids were generated for virtual screening with Generated:Article Title: Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. Article Snippet: In particular, the 3EQM PDB complex was selected as a representative structure of CYP19A1 due to the unavailability of complexes of this target with nonsteroidal ligands, and because of its higher resolution (i.e. 2.9 Å).59 4FDH51 and 6M7X49 PDB complexes were selected as representatives of the CYP11B2 and CYP11B1 enzymes, respectively, as they have been cocrystallized with (R)-fadrozole (PDB ID: 4FDH; PDB ligand ID: 0T3) and (S)-fadrozole (PDB ID: 6M7X; PDB ligand ID: JTD), which emerged in the similarity estimations; the selection of these structures is in line with good practices of structure-based multitarget drug design.70,71 The selected structures were first prepared for docking by using default parameters via the Protein Preparation Wizard utility (Schrödinger).72 Receptor grids were generated by means of the Article Title: Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway. Article Snippet: Colorectal cancer (CRC), among the most aggressive and prevailing neoplasms, is primarily treated with chemotherapy.. Voacamine (VOA), a novel bisindole natural product, possesses a variety of conspicuous pharmacological activities.. Within the current research, we evaluated in vitro and in vivo the anticancer efficacy of VOA against CRC and its potential mechanisms. Article Title: Identification of the potential biological target of N -benzenesulfonyl-1,2,3,4-tetrahydroquinoline compounds active against gram-positive and gram-negative bacteria. Article Snippet: The development of new antibiotics with activity towards a broad spectrum of bacteria, including multiresistant strains, is a very important topic for global public health.. As part of previous works, N-benzenesulfonyl-1,2,3,4-tetrahydroquinoline (BSTHQ) derivatives were described as antimicrobial agents active against Gram-positive and Gram-negative pathogens.. In this work, experimental and molecular modelling studies were performed in order to identify their potential biological target in the light of structure-based design efforts towards further BSTHQ derivatives. Article Title: Molecular Dynamics Simulations Identify Tractable Lead-like Phenyl-Piperazine Scaffolds as eIF4A1 ATP-competitive Inhibitors Article Snippet: Receptor docking grids were generated for virtual screening with Glide Receptor Grid Generation (Schrödinger Release 2019-3: Glide, Schrödinger, LLC, New York, NY, 2019) and OpenEye’s Article Title: AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK Article Snippet: Receptor docking grids were generated for virtual screening with Article Title: AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK. Article Snippet: Receptor docking grids were generated for virtual screening with |