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Forschungszentrum gmbh glc-ms analysis
Glc Ms Analysis, supplied by Forschungszentrum gmbh, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/glc-ms+analysis/hplc/pm11368168-123-9-5
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glc-ms analysis - by Bioz Stars, 2026-11
90/100 stars

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Nuclear Magnetic Resonance:

Article Title: [ 18 F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.
Article Snippet: Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-D-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline.. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsychotic potential in a number of animal models.. Whereas clinical application of ALX5407 is limited by adverse effects on motor performance and respiratory function, a suitably radiolabeled drug could represent a promising PET tracer for the visualization of GlyT1 in the brain.

High Performance Liquid Chromatography:

Article Title: [ 18 F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.
Article Snippet: Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-D-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline.. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsychotic potential in a number of animal models.. Whereas clinical application of ALX5407 is limited by adverse effects on motor performance and respiratory function, a suitably radiolabeled drug could represent a promising PET tracer for the visualization of GlyT1 in the brain.

Article Title: Characterization of recombinant thiamine diphosphate-dependent phosphonopyruvate decarboxylase from Streptomyces viridochromogenes Tü494
Article Snippet: Phosphonopyruvate decarboxylase (PPDC) catalyzes the thiamine diphosphate-dependent non-oxidative decarboxylation of phosphonopyruvate to phosphonoacetaldehyde and carbon dioxide.. The enzyme of S. viridochromogenes Tü494 was expressed as a recombinant fusion protein with an N-terminal 10× histidine-tag in Escherichia coli cells, and was purified to homogeneity by nickel affinity chromatography.. The biochemical properties of the recombinant enzyme were characterized, measuring phosphonoacetaldehyde formation by two newly developed coupled enzyme assays.

Article Title: Structure elucidation of the thermal degradation products of the nucleotide cofactors NADH and NADPH by nano-ESI-FTICR-MS and HPLC-MS.
Article Snippet: Redox cofactors like NADH and NADPH are essential for the catalytic activity of several oxidoreductases.. Here, we describe a comparative study of the thermal degradation products of both cofactors in the dry and liquid states.. The degradation products were first separated, detected, and quantified by high-performance liquid chromatography (HPLC).

Article Title: Streamlined Pseudomonas taiwanensis VLB120 Chassis Strains with Improved Bioprocess Features.
Article Snippet: Microbes harbor many traits that are dispensable or even unfavorable under industrial and laboratory settings.. The elimination of such traits could improve the host’s efficiency, genetic stability, and robustness, thereby increasing the predictability and boosting its performance as a microbial cell

In Vitro:

Article Title: [ 18 F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.
Article Snippet: Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-D-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline.. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsychotic potential in a number of animal models.. Whereas clinical application of ALX5407 is limited by adverse effects on motor performance and respiratory function, a suitably radiolabeled drug could represent a promising PET tracer for the visualization of GlyT1 in the brain.

Ex Vivo:

Article Title: [ 18 F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.
Article Snippet: Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-D-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline.. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsychotic potential in a number of animal models.. Whereas clinical application of ALX5407 is limited by adverse effects on motor performance and respiratory function, a suitably radiolabeled drug could represent a promising PET tracer for the visualization of GlyT1 in the brain.

In Vivo:

Article Title: [ 18 F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.
Article Snippet: Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-D-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline.. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsychotic potential in a number of animal models.. Whereas clinical application of ALX5407 is limited by adverse effects on motor performance and respiratory function, a suitably radiolabeled drug could represent a promising PET tracer for the visualization of GlyT1 in the brain.

Imaging:

Article Title: [ 18 F]ALX5406: A Brain-Penetrating Prodrug for GlyT1-Specific PET Imaging.
Article Snippet: Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-D-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline.. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsychotic potential in a number of animal models.. Whereas clinical application of ALX5407 is limited by adverse effects on motor performance and respiratory function, a suitably radiolabeled drug could represent a promising PET tracer for the visualization of GlyT1 in the brain.

other:

Article Title: Gamma radiolysis of hydrophilic diglycolamide ligands in concentrated aqueous nitrate solution.
Article Snippet: Irradiated samples were analyzed at Forschungszentrum Jülich (FZJ) by high performance liquid chromatography – electrospray ionization mass spectrometry/mass spectrometry (HPLC-ESI-MS/MS).

Article Title: Functional identification of a delta8-sphingolipid desaturase from Borago officinalis.
Article Snippet: Petra Sperling,* Balázs Libisch,† Ulrich Zähringer,‡ Johnathan A. Napier,† and Ernst Heinz* *Institut für Allgemeine Botanik, Universität Hamburg, Ohnhorststrasse 18, D-22609 Hamburg, Germany; †IACR-Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS 41 9 AF, United Kingdom; and ‡Laborgruppe Immunchemie, Forschungszentrum Borstel, Parkallee 22, D-23845 Borstel, Germany

Article Title: Altered turnover of β-carotene and Chl a in Arabidopsis leaves treated with lincomycin or norflurazon.
Article Snippet: Acknowledgments We thank Diana Hofmann and Stephan Köppchen (Forschungszentrum Jülich) for valuable suggestions and technical assistance with radio-HPLC analysis.

Article Title: Validation of analytical HPLC with post-column injection as a method for rapid and precise quantification of radiochemical yields.
Article Snippet: Accurate assessment of isolated radiochemical yields (RCYs) is a prerequisite for efficient and reliable optimization of labeling reactions.. In practice, radiochemical conversions (RCCs) determined by HPLC analysis of crude reaction mixtures are often used to estimate RCYs.. However, incomplete recovery of radioactivity from the stationary phase can lead to significant inaccuracies if RCCs are calculated based on the activity eluted from the column (i.e. the summed integrals of all peaks).

Mass Spectrometry:

Article Title: Characterization of recombinant thiamine diphosphate-dependent phosphonopyruvate decarboxylase from Streptomyces viridochromogenes Tü494
Article Snippet: Phosphonopyruvate decarboxylase (PPDC) catalyzes the thiamine diphosphate-dependent non-oxidative decarboxylation of phosphonopyruvate to phosphonoacetaldehyde and carbon dioxide.. The enzyme of S. viridochromogenes Tü494 was expressed as a recombinant fusion protein with an N-terminal 10× histidine-tag in Escherichia coli cells, and was purified to homogeneity by nickel affinity chromatography.. The biochemical properties of the recombinant enzyme were characterized, measuring phosphonoacetaldehyde formation by two newly developed coupled enzyme assays.

Chromatography:

Article Title: Structure elucidation of the thermal degradation products of the nucleotide cofactors NADH and NADPH by nano-ESI-FTICR-MS and HPLC-MS.
Article Snippet: Redox cofactors like NADH and NADPH are essential for the catalytic activity of several oxidoreductases.. Here, we describe a comparative study of the thermal degradation products of both cofactors in the dry and liquid states.. The degradation products were first separated, detected, and quantified by high-performance liquid chromatography (HPLC).

Ion Exchange Chromatography:

Article Title: Structure elucidation of the thermal degradation products of the nucleotide cofactors NADH and NADPH by nano-ESI-FTICR-MS and HPLC-MS.
Article Snippet: Redox cofactors like NADH and NADPH are essential for the catalytic activity of several oxidoreductases.. Here, we describe a comparative study of the thermal degradation products of both cofactors in the dry and liquid states.. The degradation products were first separated, detected, and quantified by high-performance liquid chromatography (HPLC).



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