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Simulations Plus Inc gastroplustm v9.8
Gastroplustm V9.8, supplied by Simulations Plus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gastroplustm/gastroplustm+software/pm39961585-43-0-2
Average 90 stars, based on 1 article reviews
gastroplustm v9.8 - by Bioz Stars, 2026-10
90/100 stars

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Formulation:

Article Title: RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling
Article Snippet: Using Minitab® 20 (Minitab, LLC, Pennsylvania, USA), shelf life was calculated after determining the percentage drug assay and all the critical parameters (Y1–Y4) . .. The systemic disposition of rivaroxaban from the optimized formulation (F pred ) was predicted using the ‘Advanced Compartmental Absorption and Transit’ (ACAT ®) model embedded in GastroPlusTM software version 9.9 (Simulations Plus Inc., Lancaster, CA, USA). .. Different formulation and physiological parameters (logP, blood: plasma ratio, pKa, unbound plasma fraction, effective permeability) obtained from the literature and ADMETTM predictor (Simulations Plus Inc., Lancaster, CA, USA) module were incorporated and depicted in Table , , .

Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations
Article Snippet: .. GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

Article Title: QbD-based formulation development and evaluation of lipid-cellulose-based extended-release multi-particulates of cinitapride and its in-silico PBPK modeling.
Article Snippet: The study aims to develop and optimize extended-release cinitapride matrix pellets using lipid wax glyceryl monostearate (GMS) and ethyl cellulose (EC) for treating functional dyspepsia and gastrointestinal reflux disease.. Pellets were prepared using the extrusion spheronization technique by applying central composite design (CCD), keeping EC-7cps (matrix former), spheronization speed, and time as variables.. The drug release, sphericity, and aspect ratio were quality parameters.

Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations.
Article Snippet: .. Clopidogrel-Specific PBBM Model GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

Software:

Article Title: RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling
Article Snippet: Using Minitab® 20 (Minitab, LLC, Pennsylvania, USA), shelf life was calculated after determining the percentage drug assay and all the critical parameters (Y1–Y4) . .. The systemic disposition of rivaroxaban from the optimized formulation (F pred ) was predicted using the ‘Advanced Compartmental Absorption and Transit’ (ACAT ®) model embedded in GastroPlusTM software version 9.9 (Simulations Plus Inc., Lancaster, CA, USA). .. Different formulation and physiological parameters (logP, blood: plasma ratio, pKa, unbound plasma fraction, effective permeability) obtained from the literature and ADMETTM predictor (Simulations Plus Inc., Lancaster, CA, USA) module were incorporated and depicted in Table , , .

Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations
Article Snippet: .. GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

Article Title: High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach
Article Snippet: .. The PBPK modelling and simulations of victim drugs and perpetrator (rifampicin), as well as the DDI predictions, were conducted using GastroPlusTM Software (version 9.7; Simulations Plus, Inc., Lancaster, CA, United States). ..

Article Title: Design and synthesis of novel thioether analogs as promising antiviral agents: In vitro activity against enteroviruses of interest.
Article Snippet: .. GastroPlusTM (Version 9.9; Simulations Plus, Inc., Lancaster, California, USA) software was used with a default parameter, namely the intake of a single tablet containing 100 mg of active compound, diluted in 250 mL of water, by a man on an empty stomach. ..

Article Title: QbD-based formulation development and evaluation of lipid-cellulose-based extended-release multi-particulates of cinitapride and its in-silico PBPK modeling.
Article Snippet: The study aims to develop and optimize extended-release cinitapride matrix pellets using lipid wax glyceryl monostearate (GMS) and ethyl cellulose (EC) for treating functional dyspepsia and gastrointestinal reflux disease.. Pellets were prepared using the extrusion spheronization technique by applying central composite design (CCD), keeping EC-7cps (matrix former), spheronization speed, and time as variables.. The drug release, sphericity, and aspect ratio were quality parameters.

Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations.
Article Snippet: .. Clopidogrel-Specific PBBM Model GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

Drug discovery:

Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations
Article Snippet: .. GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations.
Article Snippet: .. Clopidogrel-Specific PBBM Model GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

Polymer:

Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations
Article Snippet: .. GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations.
Article Snippet: .. Clopidogrel-Specific PBBM Model GastroPlusTM software (version 9.8.2000, Simulations Plus Inc., Research Triangle Park, NC, USA) was used to predict the pharmacokinetics of clopidogrel and the influence of formulation factors (in terms of drug release rate from the formulations with different polymer type and drug-to-polymer ratio) on the absorption and distribution of clopidogrel after peroral administration of the SDs studied. ..

other:

Article Title: Physiologically based pharmacokinetic model for oxcarbazepine active metabolite to predict pharmacokinetics in paediatric patients with renal impairment and adjust dosages.
Article Snippet: Funding information Joint Funds for the Innovation of Science and Technology, Fujian Province, China (Grant number: 2023Y9025); Natural Science Foundation of Fujian Province, China (Grant number: 2021 J01701); Young and Middleaged Backbone Personnel Training Project of Fujian Province Health and Family Planning Commission, China (Grant number: 2023GGA027); Young and Middle-aged Teachers Education Research Project of Fujian Province, China (Grant number: JAT210110).. Aims: Oxcarbazepine (OXC) has been approved as monotherapy or adjunctive therapy for paediatric partial seizures.. There are few reports on the pharmacokinetics (PK) of OXC in paediatric patients with renal impairment (RI), especially dosage studies of RI, which are rarely conducted on paediatric patients.



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Model simulations of vancomycin concentration-time profiles from four studies in the training dataset: (A) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young US population. (B) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young Chinese population. (C) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the HC group. (D) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the LC group.

Journal: Frontiers in Pharmacology

Article Title: High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

doi: 10.3389/fphar.2025.1555276

Figure Lengend Snippet: Model simulations of vancomycin concentration-time profiles from four studies in the training dataset: (A) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young US population. (B) Observed and PBPK model simulated vancomycin plasma concentrations after a single 1,000 mg intravenous dose in a young Chinese population. (C) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the HC group. (D) Observed and PBPK model simulated vancomycin plasma concentrations after multiple 1,000 mg doses every 12 h in the LC group.

Article Snippet: To assess pharmacokinetics and tissue distribution of vancomycin in PJI patients, we employed the commercially available dynamic PBPK modeling software GastroPlusTM version 9.9 (Simulations Plus, Inc.) to construct a stepwise model as previously described ( ).

Techniques: Concentration Assay, Clinical Proteomics

The model to predict vancomycin concentrations in the red marrow, yellow marrow and kidney: (A) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the HC group. (B) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the LC group. (C) Observed and PBPK model simulated concentrations in plasma and kidney in the HC group. (D) Observed and PBPK model simulated concentrations in plasma and kidney in the LC group.

Journal: Frontiers in Pharmacology

Article Title: High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis

doi: 10.3389/fphar.2025.1555276

Figure Lengend Snippet: The model to predict vancomycin concentrations in the red marrow, yellow marrow and kidney: (A) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the HC group. (B) Observed and PBPK model simulated concentrations in plasma, red marrow, and yellow marrow in the LC group. (C) Observed and PBPK model simulated concentrations in plasma and kidney in the HC group. (D) Observed and PBPK model simulated concentrations in plasma and kidney in the LC group.

Article Snippet: To assess pharmacokinetics and tissue distribution of vancomycin in PJI patients, we employed the commercially available dynamic PBPK modeling software GastroPlusTM version 9.9 (Simulations Plus, Inc.) to construct a stepwise model as previously described ( ).

Techniques: Clinical Proteomics