gastroplustm v9.8 (Simulations Plus Inc)
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Gastroplustm V9.8, supplied by Simulations Plus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gastroplustm/gastroplustm+software/pm39961585-43-0-2
Average 90 stars, based on 1 article reviews
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Formulation:Article Title: RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling Article Snippet: Using Minitab® 20 (Minitab, LLC, Pennsylvania, USA), shelf life was calculated after determining the percentage drug assay and all the critical parameters (Y1–Y4) . .. The systemic disposition of rivaroxaban from the optimized formulation (F pred ) was predicted using the ‘Advanced Compartmental Absorption and Transit’ (ACAT ®) model embedded in Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations Article Snippet: .. Article Title: QbD-based formulation development and evaluation of lipid-cellulose-based extended-release multi-particulates of cinitapride and its in-silico PBPK modeling. Article Snippet: The study aims to develop and optimize extended-release cinitapride matrix pellets using lipid wax glyceryl monostearate (GMS) and ethyl cellulose (EC) for treating functional dyspepsia and gastrointestinal reflux disease.. Pellets were prepared using the extrusion spheronization technique by applying central composite design (CCD), keeping EC-7cps (matrix former), spheronization speed, and time as variables.. The drug release, sphericity, and aspect ratio were quality parameters. Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations. Article Snippet: .. Software:Article Title: RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling Article Snippet: Using Minitab® 20 (Minitab, LLC, Pennsylvania, USA), shelf life was calculated after determining the percentage drug assay and all the critical parameters (Y1–Y4) . .. The systemic disposition of rivaroxaban from the optimized formulation (F pred ) was predicted using the ‘Advanced Compartmental Absorption and Transit’ (ACAT ®) model embedded in Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations Article Snippet: .. Article Title: High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach Article Snippet: .. The PBPK modelling and simulations of victim drugs and perpetrator (rifampicin), as well as the DDI predictions, were conducted using Article Title: Design and synthesis of novel thioether analogs as promising antiviral agents: In vitro activity against enteroviruses of interest. Article Snippet: .. Article Title: QbD-based formulation development and evaluation of lipid-cellulose-based extended-release multi-particulates of cinitapride and its in-silico PBPK modeling. Article Snippet: The study aims to develop and optimize extended-release cinitapride matrix pellets using lipid wax glyceryl monostearate (GMS) and ethyl cellulose (EC) for treating functional dyspepsia and gastrointestinal reflux disease.. Pellets were prepared using the extrusion spheronization technique by applying central composite design (CCD), keeping EC-7cps (matrix former), spheronization speed, and time as variables.. The drug release, sphericity, and aspect ratio were quality parameters. Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations. Article Snippet: .. Drug discovery:Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations Article Snippet: .. Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations. Article Snippet: .. Polymer:Article Title: In Vitro–In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations Article Snippet: .. Article Title: In Vitro-In Silico Approach in the Development of Clopidogrel Solid Dispersion Formulations. Article Snippet: .. other:Article Title: Physiologically based pharmacokinetic model for oxcarbazepine active metabolite to predict pharmacokinetics in paediatric patients with renal impairment and adjust dosages. Article Snippet: Funding information Joint Funds for the Innovation of Science and Technology, Fujian Province, China (Grant number: 2023Y9025); Natural Science Foundation of Fujian Province, China (Grant number: 2021 J01701); Young and Middleaged Backbone Personnel Training Project of Fujian Province Health and Family Planning Commission, China (Grant number: 2023GGA027); Young and Middle-aged Teachers Education Research Project of Fujian Province, China (Grant number: JAT210110).. Aims: Oxcarbazepine (OXC) has been approved as monotherapy or adjunctive therapy for paediatric partial seizures.. There are few reports on the pharmacokinetics (PK) of OXC in paediatric patients with renal impairment (RI), especially dosage studies of RI, which are rarely conducted on paediatric patients. |
