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fty720-p  (Novartis)

 
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    Novartis fty720-p
    Fty720 P, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/fty720/pmc11066976-24-0-2
    Average 90 stars, based on 1 article reviews
    fty720-p - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    other:

    Article Title: Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence
    Article Snippet: While the therapeutic role of receptor-mediated sphingosine-1-phosphate (S1P) signaling is well established in multiple sclerosis, where FTY720 (fingolimod, Gilenya TM , Novartis Basel, Switzerland), a non-selective S1P receptor modulator, is widely used, its relevance extends notably to cerebral ischemia.

    Article Title: Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence.
    Article Snippet: The adverse effect profile and safety data of FTY720 have been thoroughly documented by Novartis, Switzerland.

    Article Title:
    Article Snippet: By the end of 2009, Novartis also plans to file for approval of the innovative oral therapy FTY720 (fingolimod).

    Article Title: Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence
    Article Snippet: The adverse effect profile and safety data of FTY720 have been thoroughly documented by Novartis, Switzerland.

    Article Title:
    Article Snippet: · Novartis committed to MS through extensive research and development programs, including novel oral therapy FTY720 currently in Phase III trials

    Article Title: Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence.
    Article Snippet: While the therapeutic role of receptor-mediated sphingosine-1-phosphate (S1P) signaling is well established in multiple sclerosis, where FTY720 (fingolimod, GilenyaTM, Novartis Basel, Switzerland), a non-selective S1P receptor modulator, is widely used, its relevance extends notably to cerebral ischemia.

    Functional Assay:

    Article Title: The Dual Faces of S1P: Orchestrating Immune Responses in Health and Disease
    Article Snippet: .. The significance of S1P signaling on human health first became evident with the discovery of the novel immunosuppressive drug FTY720 (Fingolimod, Gilenya, Novartis), a S1P receptor functional antagonist, which triggers lymphopenia and has been used to suppress autoimmune diseases such as multiple sclerosis [ , , ]. ..

    Article Title: The Dual Faces of S1P: Orchestrating Immune Responses in Health and Disease.
    Article Snippet: .. The significance of S1P signaling on human health first became evident with the discovery of the novel immunosuppressive drug FTY720 (Fingolimod, Gilenya, Novartis), a S1P receptor functional antagonist, which triggers lymphopenia and has been used to suppress autoimmune diseases such as multiple sclerosis [2–4]. ..



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    Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques:

    Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Membrane, Control

    Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Binding Assay

    The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Binding Assay

    Chemical structures of a sphingosine 1-phosphate, b fingolimod, c fingolimod phosphate, d bis-imidazolium functional monomer, and e divinylbenzene cross-linker

    Journal: Analytical and Bioanalytical Chemistry

    Article Title: Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate

    doi: 10.1007/s00216-023-04937-8

    Figure Lengend Snippet: Chemical structures of a sphingosine 1-phosphate, b fingolimod, c fingolimod phosphate, d bis-imidazolium functional monomer, and e divinylbenzene cross-linker

    Article Snippet: Fingolimod (FTY720) and fingolimod phosphate (FTY720-P, FP) were purchased from Novartis Institutes for BioMedical Research (Basel, Switzerland).

    Techniques: Functional Assay