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fty720-p  (Novartis)

 
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    Structured Review

    Novartis fty720-p
    Fty720 P, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fty720-p/fty720/pmc11066976-24-0-2
    Average 90 stars, based on 1 article reviews
    fty720-p - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Fluorescence:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    RNA Sequencing Assay:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Expressing:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Immunohistochemistry:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Immunolabeling:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    MANN-WHITNEY:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Binding Assay:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Mutagenesis:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Flow Cytometry:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Functional Assay:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Inhibition:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Recombinant:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Isolation:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Sequencing:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Software:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Western Blot:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Molecular Weight:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Membrane:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Microscopy:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.

    Staining:

    Article Title: Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways
    Article Snippet: Siponimod/BAF312 and FTY720-p used in this study were supplied by Novartis Pharmaceuticals Corporation (Basel, Switzerland) and dissolved in DMSO solution.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: FTY720 and FTY720-p, the phosphorylated, active form of FTY720, were kindly provided by Novartis (Basel, Switzerland).

    Article Title: Role of p38MAPK in S1P receptor-mediated differentiation of human oligodendrocyte progenitors.
    Article Snippet: FTY720 is a sphingosine 1-phosphate receptor (S1PR) modulator used as a daily therapy to reduce disease activity in the relapsing form of multiple sclerosis (MS).. FTY720 readily accesses the CNS.. Previous studies have shown that phosphorylated FTY720 (FTY720-p) enhances oligodendrocyte progenitor cell (OPC) survival, differentiation, and remyelination following experimentally induced demyelination in rodents.

    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p, Dr. Elsa Bello-Reuss (Texas Tech University) for providing TKPTS cells, and all members of the Okusa laboratory.


    Article Title: Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury
    Article Snippet: We gratefully acknowledge the University of Virginia Advanced Microscopy Facility for ultrathin sectioning and staining and the University of Virginia Research Histology core, Dr. V. Brinkmann (Novartis, Basel, Switzerland) for providing FTY720-p,Dr.

    Article Title: Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 signaling induces COX-2 expression in Wilms tumor
    Article Snippet: We thank Dr. Herman Yeger for the WiT49 cell line, Novartis Pharma for FTY720-P and the Children’s Oncology Group Biopathology Center for the Wilms tumor specimens.



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    Image Search Results


    Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Effects of cytotoxicity observed with FTY720 (S)-P exposure on HepG2 cells after 24–48 and 72 h treatment. The cells were treated with 0.3125–10 μM concentrations.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques:

    Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Effects of FTY720-S(P) (0.3125–10 μM) on cell viability by A) MTT, B) LDH and C) NRU assays in HepG2 cells after 72 h treatments. The cells were treated with 0.3125–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in the ATP content observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in mitochondrial membrane potential (MMP) observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Quadrants of JC-1 aggregates (PE channel) and monomers (FITC channel), B) MMP levels. The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05 and * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Membrane, Control

    Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Oxidative stress production observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Cellular ROS production, B) mitochondrial ROS production. The cells were treated with 0,625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Changes in antioxidant enzyme levels observed with FTY720 (S)-P exposure on HepG2 cells after 72 h treatment. A) Total superoxide dismutase (T-SOD), B) glutathione (GSH), (C) catalase (CAT). The cells were treated with 0.625–10 μM concentrations. Data are expressed as mean ± SD, * P < 0.05, * * P < 0.01 versus the control group.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Control

    Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: Molecular docking of FTY720 (S)-P depicted as 2D and 3D simulations within the binding sites of human SIRT3 (A) and SIRT5 (B), utilizing the X-ray crystallographic structures with PDB codes 4JSR and 5XHS, respectively.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Binding Assay

    The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.

    Journal: Toxicology Research

    Article Title: In vitro investigation of the toxicological mechanisms of Fingolimod (S)-phosphate in HEPG2 cells

    doi: 10.1093/toxres/tfaf064

    Figure Lengend Snippet: The Interaction profiles and docking scores of FTY720 (S)-P within the binding pocket of the SIRT3 (PDB ID: 4JSR) and SIRT5 (PDB ID: 5XHS) proteins.

    Article Snippet: FTY720 (S)-P was purchased from Cayman Chemical Company (USA) and dissolved in dimethyl sulfoxide (DMSO).

    Techniques: Binding Assay

    Chemical structures of a sphingosine 1-phosphate, b fingolimod, c fingolimod phosphate, d bis-imidazolium functional monomer, and e divinylbenzene cross-linker

    Journal: Analytical and Bioanalytical Chemistry

    Article Title: Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate

    doi: 10.1007/s00216-023-04937-8

    Figure Lengend Snippet: Chemical structures of a sphingosine 1-phosphate, b fingolimod, c fingolimod phosphate, d bis-imidazolium functional monomer, and e divinylbenzene cross-linker

    Article Snippet: Fingolimod (FTY720) and fingolimod phosphate (FTY720-P, FP) were purchased from Novartis Institutes for BioMedical Research (Basel, Switzerland).

    Techniques: Functional Assay