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extem a10  (Rotem Industries)

 
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    Structured Review

    Rotem Industries extem a10
    Extem A10, supplied by Rotem Industries, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/extem/a10+assay+clauss+fibrinogen+fibtem+%E2%80%A2/pm41125237-2649-7-18
    Average 86 stars, based on 1 article reviews
    extem a10 - by Bioz Stars, 2026-11
    86/100 stars

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    Related Articles

    Functional Assay:

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. Spinal surgery: FC dose was calculated based on body weight (BW) and functional fibrinogen level from clot amplitude after 10 min (FIBTEM A10; measured intraoperatively by rotational thromboelastometry [ROTEM] using ROTEM delta and ROTEM sigma devices [Werfen GmbH, Munich, Germany]), with the aim to restore patient's individual baseline fibrinogen level. ..

    FIBTEM Assay:

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. Spinal surgery: FC dose was calculated based on body weight (BW) and functional fibrinogen level from clot amplitude after 10 min (FIBTEM A10; measured intraoperatively by rotational thromboelastometry [ROTEM] using ROTEM delta and ROTEM sigma devices [Werfen GmbH, Munich, Germany]), with the aim to restore patient's individual baseline fibrinogen level. ..

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) • Coagulation factors ..

    Article Title: ISBT and ANZSBT abstracts of the joint Blood2025-ISBT 36th Regional Congress, Perth, Australia, 26-29 October 2025.
    Article Snippet: Medicinal products derived from human blood and plasma donations are essential to healthcare worldwide.. In 2010, the World Health Assembly adopted resolution WHA 63.12, urging Member States to establish, implement, and support nationally coordinated, well-managed, and sustainable blood and plasma programs to achieve self-sufficiency.. To monitor the global availability, safety, and accessibility of blood for transfusion, the World Health Organization (WHO) launched the Global Database on Blood Safety (GDBS) in 1998.

    Article Title: Viscoelastic haemostatic assays in chronic liver disease—Profiling coagulation in the emergency department
    Article Snippet: .. ROTEM: FIBTEM A10 < 11 mm , 225 (56.7%) , 19 (46.3%). ..

    Article Title: Viscoelastic haemostatic assays in chronic liver disease—Profiling coagulation in the emergency department
    Article Snippet: .. ROTEM: FIBTEM A10 ≥ 11 mm + EXTEM A10 < 43 mm , 45 (11.3%) , 3 (7.3%). ..

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) Follow-up Visit Day 2: All subjects treated with IMP will attend the follow-up visit one day after surgery (Day 2). ..

    Coagulation:

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) • Coagulation factors ..

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) Follow-up Visit Day 2: All subjects treated with IMP will attend the follow-up visit one day after surgery (Day 2). ..

    Activation Assay:

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) • Coagulation factors ..

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) Follow-up Visit Day 2: All subjects treated with IMP will attend the follow-up visit one day after surgery (Day 2). ..

    Clinical Proteomics:

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) • Coagulation factors ..

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) Follow-up Visit Day 2: All subjects treated with IMP will attend the follow-up visit one day after surgery (Day 2). ..

    Activity Assay:

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) • Coagulation factors ..

    Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial
    Article Snippet: .. • Markers of coagulation (Coagulation activation tests) • Plasma activity of fibrinogen (Clauss assay) • FIBTEM A10 and MCF (ROTEM) Follow-up Visit Day 2: All subjects treated with IMP will attend the follow-up visit one day after surgery (Day 2). ..



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    (a) Violin plots of rotational thromboelastometry (ROTEM) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and interquartile ranges (IQRs) and red shaded reference ranges. (b) Violin plots of thromboelastogram (TEG) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and IQRs and red shaded reference ranges. <t>A10,</t> amplitude 10 min after start of clotting time (CT); CFF, clot formation time; CK R, clotting time (R‐time) in citrated kaolin channel of TEG 6s; CRT, clot reaction time; EXTEM, extrinsically activated thromboelastometry; FIBTEM, fibrin‐based thromboelastometry; LY30, lysis 30 min after maximum amplitude; MA, maximum amplitude; ML, maximum lysis.
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    (a) Violin plots of rotational thromboelastometry (ROTEM) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and interquartile ranges (IQRs) and red shaded reference ranges. (b) Violin plots of thromboelastogram (TEG) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and IQRs and red shaded reference ranges. <t>A10,</t> amplitude 10 min after start of clotting time (CT); CFF, clot formation time; CK R, clotting time (R‐time) in citrated kaolin channel of TEG 6s; CRT, clot reaction time; EXTEM, extrinsically activated thromboelastometry; FIBTEM, fibrin‐based thromboelastometry; LY30, lysis 30 min after maximum amplitude; MA, maximum amplitude; ML, maximum lysis.
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    Image Search Results


    (a) Violin plots of rotational thromboelastometry (ROTEM) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and interquartile ranges (IQRs) and red shaded reference ranges. (b) Violin plots of thromboelastogram (TEG) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and IQRs and red shaded reference ranges. A10, amplitude 10 min after start of clotting time (CT); CFF, clot formation time; CK R, clotting time (R‐time) in citrated kaolin channel of TEG 6s; CRT, clot reaction time; EXTEM, extrinsically activated thromboelastometry; FIBTEM, fibrin‐based thromboelastometry; LY30, lysis 30 min after maximum amplitude; MA, maximum amplitude; ML, maximum lysis.

    Journal: Vox Sanguinis

    Article Title: Viscoelastic haemostatic assays in chronic liver disease—Profiling coagulation in the emergency department

    doi: 10.1111/vox.70167

    Figure Lengend Snippet: (a) Violin plots of rotational thromboelastometry (ROTEM) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and interquartile ranges (IQRs) and red shaded reference ranges. (b) Violin plots of thromboelastogram (TEG) parameters ( n = 397). Blue violins show distributions with individual values (crosses), annotated medians and IQRs and red shaded reference ranges. A10, amplitude 10 min after start of clotting time (CT); CFF, clot formation time; CK R, clotting time (R‐time) in citrated kaolin channel of TEG 6s; CRT, clot reaction time; EXTEM, extrinsically activated thromboelastometry; FIBTEM, fibrin‐based thromboelastometry; LY30, lysis 30 min after maximum amplitude; MA, maximum amplitude; ML, maximum lysis.

    Article Snippet: ROTEM: FIBTEM A10 ≥ 11 mm + EXTEM A10 < 43 mm , 45 (11.3%) , 3 (7.3%).

    Techniques: Coagulation, FIBTEM Assay, Lysis

    (a) Patient‐level combinations of fibrinogen, platelet and coagulation factor deficiencies, and hyperfibrinolysis in rotational thromboelastometry (ROTEM) ( n = 397). (b) Patient‐level combinations of fibrinogen, platelet and coagulation factor deficiencies, and hyperfibrinolysis in thromboelastogram (TEG) ( n = 41). A10, amplitude 10 min after start of clotting time (CT); CFF, clot formation time; CK R, clotting time (R‐time) in citrated kaolin channel of TEG 6s; CRT, clot reaction time; EXTEM, extrinsically activated thromboelastometry; FIBTEM, fibrin‐based thromboelastometry; LY30, lysis 30 min after maximum amplitude; MA, maximum amplitude; ML, maximum lysis.

    Journal: Vox Sanguinis

    Article Title: Viscoelastic haemostatic assays in chronic liver disease—Profiling coagulation in the emergency department

    doi: 10.1111/vox.70167

    Figure Lengend Snippet: (a) Patient‐level combinations of fibrinogen, platelet and coagulation factor deficiencies, and hyperfibrinolysis in rotational thromboelastometry (ROTEM) ( n = 397). (b) Patient‐level combinations of fibrinogen, platelet and coagulation factor deficiencies, and hyperfibrinolysis in thromboelastogram (TEG) ( n = 41). A10, amplitude 10 min after start of clotting time (CT); CFF, clot formation time; CK R, clotting time (R‐time) in citrated kaolin channel of TEG 6s; CRT, clot reaction time; EXTEM, extrinsically activated thromboelastometry; FIBTEM, fibrin‐based thromboelastometry; LY30, lysis 30 min after maximum amplitude; MA, maximum amplitude; ML, maximum lysis.

    Article Snippet: ROTEM: FIBTEM A10 ≥ 11 mm + EXTEM A10 < 43 mm , 45 (11.3%) , 3 (7.3%).

    Techniques: Coagulation, FIBTEM Assay, Lysis

    Concordance of fibrinogen, platelet and coagulation factor deficiencies detected by viscoelastic haemostatic assay (VHA) and conventional coagulation test (CCT) in paired samples ( n = 120). Rotational thromboelastometry (ROTEM) and thromboelastogram (TEG) were combined. Definitions: Fibrinogen—ROTEM: Fibrin‐based thromboelastometry (FIBTEM) amplitude 10 min after start of clotting time (CT) (A10) <11 mm; TEG: citrated functional fibrinogen (CFF) maximum amplitude (MA) <15 mm; CCT: Fibrinogen <1.0 g/L. Platelet—ROTEM: FIBTEM A10 ≥11 mm + extrinsically activated thromboelastometry (EXTEM) A10 <43 mm; TEG: CFF MA ≥15 mm + clot reaction time (CRT) MA <50 mm; CCT: Platelets <50 × 10 9 /L. Coagulation factor—ROTEM: EXTEM CT >80 s; TEG: Clotting time (R‐time) in citrated kaolin channel of TEG 6s (CK R) > 9 min; CCT: international normalized ratio (INR) >1.5.

    Journal: Vox Sanguinis

    Article Title: Viscoelastic haemostatic assays in chronic liver disease—Profiling coagulation in the emergency department

    doi: 10.1111/vox.70167

    Figure Lengend Snippet: Concordance of fibrinogen, platelet and coagulation factor deficiencies detected by viscoelastic haemostatic assay (VHA) and conventional coagulation test (CCT) in paired samples ( n = 120). Rotational thromboelastometry (ROTEM) and thromboelastogram (TEG) were combined. Definitions: Fibrinogen—ROTEM: Fibrin‐based thromboelastometry (FIBTEM) amplitude 10 min after start of clotting time (CT) (A10) <11 mm; TEG: citrated functional fibrinogen (CFF) maximum amplitude (MA) <15 mm; CCT: Fibrinogen <1.0 g/L. Platelet—ROTEM: FIBTEM A10 ≥11 mm + extrinsically activated thromboelastometry (EXTEM) A10 <43 mm; TEG: CFF MA ≥15 mm + clot reaction time (CRT) MA <50 mm; CCT: Platelets <50 × 10 9 /L. Coagulation factor—ROTEM: EXTEM CT >80 s; TEG: Clotting time (R‐time) in citrated kaolin channel of TEG 6s (CK R) > 9 min; CCT: international normalized ratio (INR) >1.5.

    Article Snippet: ROTEM: FIBTEM A10 ≥ 11 mm + EXTEM A10 < 43 mm , 45 (11.3%) , 3 (7.3%).

    Techniques: Coagulation, FIBTEM Assay, Functional Assay

    Graphical representation of ROTEM assay (EXTEM, INTEM, FIBTEM). ROTEM = Rotational thromboelastometry

    Journal: Indian Journal of Anaesthesia

    Article Title: Rotational thromboelastometry (ROTEM) based comparison of coagulation parameters in transurethral resection of the prostate surgery using saline versus glycine as an irrigant fluid – A prospective observational comparative study

    doi: 10.4103/ija.ija_553_25

    Figure Lengend Snippet: Graphical representation of ROTEM assay (EXTEM, INTEM, FIBTEM). ROTEM = Rotational thromboelastometry

    Article Snippet: ROTEM – EXTEM , Clotting time (CT, s) , 106.05 (77.37) , 83.78 (44.87) , 0.119 , — , —.

    Techniques: FIBTEM Assay