Journal: Diagnostics

Article Title: COVID-19 Infection-Related Coagulopathy and Viscoelastic Methods: A Paradigm for Their Clinical Utility in Critical Illness

doi: 10.3390/diagnostics10100817

Figure Lengend Snippet: Studies assessing the hemostatic profiles in critically ill COVID-19 patients by viscoelastic methods.

Article Snippet: Collett et al., 2020 [ ] , COVID-19 ICU (6) , ROTEM (EXTEM, INTEM, FIBTEM) , A10, CFT, MCF, ML , Reference ranges , Hypercoagulability with minimal fibrinolysis , Thromboprophylaxis , Three patients developed VTE.

Techniques: FIBTEM Assay, Infection

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Comparison of extrinsically stimulated assays between ClotPro ® and ROTEM ® . ( A ): clotting time; ( B ): clot firmness after 5 min (A5 value); and ( C ): clot firmness after 10 min (A10 value); ( D ): maximal clot firmness (MCF value). On the left: Fit plot with a regression line. The blue area around the regression line represents 95% confidence limits for the regression line. The p -value and Pearson’s correlation coefficient “r” are in the lower right corner. In the middle: Bland–Altman plot of the absolute values. On the right: Bland–Altman plot of the relative values. The solid black line indicates zero difference; the red solid line represents the actual mean bias between the ClotPro ® and ROTEM ® parameters; the dashed lines represent the 95% limits of acceptance (95% LOA); the dotted line represents the 99% LOA; and the blue line represents the regression line for the difference between ClotPro ® and ROTEM ® . The numeric values of the mean bias and of the lower and upper 95% LOA are given in the bottom right corner. The clotting times are measured in seconds, and the clot firmness is measured in mm amplitude, respectively.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: Comparison, Coagulation

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Comparison of intrinsically stimulated assays between ClotPro ® and ROTEM ® . ( A ): clotting time; ( B ): clot firmness after 5 min (A5 value); ( C ): clot firmness after 10 min (A10 value); and ( D ): maximal clot firmness (MCF value). On the left: Fit plot with a regression line. The blue area around the regression line represents the 95% confidence limits for the regression line. The p -value and Pearson’s correlation coefficient “r” are in the lower right corner. In the middle: Bland–Altman plot of the absolute values. On the right: Bland–Altman plot of the relative values. The solid black line indicates zero difference; the red solid line represents the actual mean bias between the ClotPro ® and ROTEM ® parameters; The dashed lines represents the 95% limits of acceptance (95% LOA); the dotted line represents the 99% LOA; and the blue line represents the regression line for the difference between ClotPro ® and ROTEM ® . The numeric values of the mean bias and of the lower and upper 95% LOA are given in the bottom right corner. The clotting times are measured in seconds, and the clot firmness is measured in mm amplitude, respectively.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: Comparison, Coagulation

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Comparison of fibrin polymerization assays between ClotPro ® and ROTEM ® . ( A ): clot firmness after 5 min (A5 value); ( B ): clot firmness after 10 min (A10 value); and ( C ): maximal clot firmness (MCF value). On the left: Fit plot with a regression line. The blue area around the regression line represents the 95% confidence limits for the regression line. The p -value and Pearson’s correlation coefficient “r” are located in the lower right corner. In the middle: Bland–Altman plot of the absolute values. On the right: Bland–Altman plot of the relative values. The solid black line indicates zero difference; the red solid line represents the actual mean bias between the ClotPro ® and ROTEM ® parameters; the dashed lines represents the 95% limits of acceptance (95% LOA); the dotted line represents the 99% LOA; and the blue line represents the regression line for the difference between ClotPro ® and ROTEM ® . The numeric values of the mean bias and of the lower and upper 95% LOA are given in the bottom right corner. The clotting times are measured in seconds, and the clot firmness is measured in mm amplitude, respectively.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: Comparison, Coagulation

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Cutoff calculations for ROTEM ® and ClotPro ® parameters based on standard laboratory values.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques: FIBTEM Assay

Journal: Journal of Clinical Medicine

Article Title: Comparison of Two Viscoelastic Testing Devices in a Parturient Population

doi: 10.3390/jcm13030692

Figure Lengend Snippet: Receiver operating characteristics (ROC) curve of the VAH parameters for defined laboratory cutoffs. Low PT = PT < 100 s; low fibrinogen = fibrinogen < 4 g/L; low platelets = platelet count < 150/nL; CP = ClotPro ® ; R = ROTEM ® ; PT = prothrombin time and PC = platelet contribution.

Article Snippet: PT < 100% vs. ROTEM ® EXTEM CT [s] , 29 vs. 602 , 0.6748 (0.59–0.76) , 49 s , 0.31 , 82.8% , 47.8% , 0.07 , 0.93.

Techniques:

Journal: Cureus

Article Title: Viscoelastometry to Manage Bleeding in Liver Disease

doi: 10.7759/cureus.41401

Figure Lengend Snippet: Studies evaluating viscoelastic testing as a predictor of bleeding in liver disease. ACLF = acute-on-chronic liver failure; CT = clotting time; FFP = fresh frozen plasma; MCF = maximal clot firmness; RBC = red blood cell; TXA = tranexamic acid; SCT = standard coagulation tests

Article Snippet: Examples of tests employed by two instruments, ROTEM and ClotPro, in the setting of liver disease are the EXTEM (ROTEM) and EX-test (ClotPro) that test the extrinsic pathway, INTEM (ROTEM) and IN-test (ClotPro) that test the intrinsic pathway, FIBTEM (ROTEM) and FIB-test (ClotPro) that assess fibrinogen contribution, and APTEM (ROTEM) and AP-test (ClotPro) that evaluate fibrinolysis.

Techniques: Coagulation, Clinical Proteomics, Transplantation Assay, FIBTEM Assay, Virus

Journal: Cureus

Article Title: Viscoelastometry to Manage Bleeding in Liver Disease

doi: 10.7759/cureus.41401

Figure Lengend Snippet: Studies investigating viscoelastic testing goal-directed algorithms in liver transplantation. CT = clotting time; FFP = fresh frozen plasma; Hb = haemoglobin; INR = international normalised ratio; MA = maximum amplitude; MCF = maximal clot firmness; RBC = red blood cell; RCT = randomised control trial; R time = reaction time; TEG = thromboelastograpthy; TXA = tranexamic acid; SCT = standard coagulation tests

Article Snippet: Examples of tests employed by two instruments, ROTEM and ClotPro, in the setting of liver disease are the EXTEM (ROTEM) and EX-test (ClotPro) that test the extrinsic pathway, INTEM (ROTEM) and IN-test (ClotPro) that test the intrinsic pathway, FIBTEM (ROTEM) and FIB-test (ClotPro) that assess fibrinogen contribution, and APTEM (ROTEM) and AP-test (ClotPro) that evaluate fibrinolysis.

Techniques: Transplantation Assay, Coagulation, Clinical Proteomics, Control, Concentration Assay, FIBTEM Assay, Lysis

Journal: PLoS ONE

Article Title: Thromboelastometry profile in critically ill patients: A single-center, retrospective, observational study

doi: 10.1371/journal.pone.0192965

Figure Lengend Snippet: Coagulation profile of studied patients.

Article Snippet: Rotational thromboelastometry (ROTEM®, TEM International GmbH, Munich, Germany) analyses were performed with EXTEM (extrinsic coagulation pathway assessment), INTEM (intrinsic coagulation pathway assessment) and FIBTEM (extrinsic coagulation pathway assessment with additional platelet inhibition using Cytochalasin D) tests according to the manufacturer’s instructions [ ].

Techniques: Coagulation, FIBTEM Assay

Journal: PLoS ONE

Article Title: Thromboelastometry profile in critically ill patients: A single-center, retrospective, observational study

doi: 10.1371/journal.pone.0192965

Figure Lengend Snippet: Conventional coagulation tests according to rotational thromboelastometry profile.

Article Snippet: Rotational thromboelastometry (ROTEM®, TEM International GmbH, Munich, Germany) analyses were performed with EXTEM (extrinsic coagulation pathway assessment), INTEM (intrinsic coagulation pathway assessment) and FIBTEM (extrinsic coagulation pathway assessment with additional platelet inhibition using Cytochalasin D) tests according to the manufacturer’s instructions [ ].

Techniques: Coagulation, FIBTEM Assay

Journal: PLoS ONE

Article Title: Thromboelastometry profile in critically ill patients: A single-center, retrospective, observational study

doi: 10.1371/journal.pone.0192965

Figure Lengend Snippet: Transfusion therapy according to rotational thromboelastometry profile.

Article Snippet: Rotational thromboelastometry (ROTEM®, TEM International GmbH, Munich, Germany) analyses were performed with EXTEM (extrinsic coagulation pathway assessment), INTEM (intrinsic coagulation pathway assessment) and FIBTEM (extrinsic coagulation pathway assessment with additional platelet inhibition using Cytochalasin D) tests according to the manufacturer’s instructions [ ].

Techniques: Clinical Proteomics, FIBTEM Assay

Journal: Journal of Cardiothoracic Surgery

Article Title: Factors affecting postoperative blood loss in children undergoing cardiac surgery

doi: 10.1186/1749-8090-9-32

Figure Lengend Snippet: Coagulation parameters based on age and the presence of cyanotic disease. (A) Fibrinogen levels measured using the Clauss method at baseline and after cardiopulmonary bypass (CPB) (p < 0.001). (B) Platelet count at baseline and after CPB (p < 0.001). (C) Maximal clot firmness obtained on FIBTEM after CPB. (D) Maximal clot firmness obtained on EXTEM after CPB. ***p < 0.001 comparing < 1 month and all other groups with cyanotic and non-cyanotic diseases, #p < 0.01 comparing < 1 month and all other groups with cyanotic diseases. Blue, cyanotic patients; red, non-cyanotic patients; clear symbols represent baseline tests; and full symbols represent post-CPB tests.

Article Snippet: Ten minutes after protamine administration, blood samples were drawn to measure platelet count, fibrinogen plasma concentration (Claus method), and parameters determined by the EXTEM and FIBTEM tests on ROTEM® (ROTEM®, TEM® International GmbH, Munich, Germany).

Techniques: Coagulation, FIBTEM Assay