epigenetic compound screen (TargetMol)
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epigenetic compound screen
Epigenetic Compound Screen, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/epigenetic+modification/Histone+Modification+Compound+Library/pmc12830624-24-13-30
Average 94 stars, based on 19 article reviews
Epigenetic Compound Screen, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/epigenetic+modification/Histone+Modification+Compound+Library/pmc12830624-24-13-30
Average 94 stars, based on 19 article reviews
epigenetic compound screen - by Bioz Stars,
2026-10
94/100 stars
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1) Product Images from "Identification of targetable epigenetic vulnerabilities for uveal melanoma"
Article Title: Identification of targetable epigenetic vulnerabilities for uveal melanoma
Journal: Cell Death & Disease
doi: 10.1038/s41419-025-08295-4
Figure Legend Snippet: A Mean viability of the three UM cell lines following 72 h treatment with 932 epigenetic modulators at a concentration of 1 μM ( n = 2) relative to the negative control (0.1% DMSO treatment). Hit cut-offs (dashed lines) were determined as the mean percentage viability of the negative controls in each cell line minus three standard deviations. Yellow dashed line is the hit cut-off for MP41 cells (65.8% viability), purple dashed line is the hit cut-off for MP46 cells (74.0% viability), and the green dashed line is the hit cut-off for MP38 cells (58.9% viability). For full list of compounds and average UM cell viabilities, see Supplementary Data . B Radar plot showing the mean difference in percent of cell viability of UM cells caused by 72 h 1 μM treatment with 932 compounds, relative to the DMSO control. Negative values, shown in gray, indicate ineffective compounds leading to greater cell viability than the negative control. The positive values, shown in color, indicate compounds that induced cell death, with higher peaks indicating greater cell death. Compounds are grouped by drug mechanism of action. C Pie charts of the molecular activities of all screened compounds ( n = 932) (left) and the hits identified ( n = 24) (right). D Concentration-response experiments for the 24 hit compounds (10 concentrations, n = 4 per concentration per cell line). Center values represent mean viability, error bars represent standard error of mean (SEM). E Log IC 50 (M) values of the top hit compounds for each cell line. Error bars represent 95% confidence interval. F Log IC 50 (M) of BAP1 mutant cell lines (MP46 and MP38) plotted against the log IC 50 (M) of the BAP1 wildtype cell line (MP41) for each drug treatment.
Techniques Used: Concentration Assay, Negative Control, Control, Mutagenesis
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Modification:Article Title: WTAP-mediated m 6 A methylation of PHF19 facilitates cell cycle progression by remodeling the accessible chromatin landscape in t(8;21) AML. Article Snippet: To induce the protein expression of HIF1α, cells were treated with 100 μM CoCl2.6H2O (Sigma-Aldrich, #C8661-25G) for 24 h. Cells treated with 0.1% (v/v) dimethyl sulfoxide (DMSO) served as the vehicle control. .. To test the drug sensitivity of Drug discovery:Article Title: WTAP-mediated m 6 A methylation of PHF19 facilitates cell cycle progression by remodeling the accessible chromatin landscape in t(8;21) AML. Article Snippet: To induce the protein expression of HIF1α, cells were treated with 100 μM CoCl2.6H2O (Sigma-Aldrich, #C8661-25G) for 24 h. Cells treated with 0.1% (v/v) dimethyl sulfoxide (DMSO) served as the vehicle control. .. To test the drug sensitivity of Article Title: Identification of targetable epigenetic vulnerabilities for uveal melanoma Article Snippet: .. Given the global epigenetic changes elicited by BAP1 loss, we performed a comprehensive Article Title: Pharmacological inhibition of histone deacetylase 6 and DNA damage repair enhances radiosensitivity in melanoma. Article Snippet: 16 Melanoma, a malignant tumour originating from melanin-producing melanocytes, poses a 17 significant threat to human health, including cutaneous melanoma and uveal melanoma 18 (UM).. Although surgical resection remains a primary treatment modality, radiotherapy has 19 emerged as another therapeutic option, particularly for UM.. Nevertheless, the adverse 20 effects induced by radiotherapy are considerably pronounced. Concentration Assay:Article Title: WTAP-mediated m 6 A methylation of PHF19 facilitates cell cycle progression by remodeling the accessible chromatin landscape in t(8;21) AML. Article Snippet: To induce the protein expression of HIF1α, cells were treated with 100 μM CoCl2.6H2O (Sigma-Aldrich, #C8661-25G) for 24 h. Cells treated with 0.1% (v/v) dimethyl sulfoxide (DMSO) served as the vehicle control. .. To test the drug sensitivity of Screening:Article Title: Pharmacological inhibition of histone deacetylase 6 and DNA damage repair enhances radiosensitivity in melanoma. Article Snippet: 16 Melanoma, a malignant tumour originating from melanin-producing melanocytes, poses a 17 significant threat to human health, including cutaneous melanoma and uveal melanoma 18 (UM).. Although surgical resection remains a primary treatment modality, radiotherapy has 19 emerged as another therapeutic option, particularly for UM.. Nevertheless, the adverse 20 effects induced by radiotherapy are considerably pronounced. other:Article Title: Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer Article Snippet: A high-throughput drug screen was performed using a compound library consisting of 619 compounds, including 59 SGC epigenetic compounds, |
