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dna microarray gene detection system  (CapitalBio Corporation)

 
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    CapitalBio Corporation dna microarray gene detection system
    The layout of the <t>DNA</t> <t>microarray</t> method module; each detection panel includes 4 detection modules, which can detect two specimens at the same time. Modules 1 and 3 are used to detect mutations in the rpoB gene, and modules 2 and 4 are used to detect mutations in the katG gene and inhA promoter. QC quality control probe; EC external control probe; BC blank control; NC negative control probe; IC internal control probe; WT wild-type.
    Dna Microarray Gene Detection System, supplied by CapitalBio Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dna+microarray+systems/dna+microarray/pmc08429459-155-18-15
    Average 90 stars, based on 1 article reviews
    dna microarray gene detection system - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study"

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study

    Journal: Scientific Reports

    doi: 10.1038/s41598-021-97559-y

    The layout of the DNA microarray method module; each detection panel includes 4 detection modules, which can detect two specimens at the same time. Modules 1 and 3 are used to detect mutations in the rpoB gene, and modules 2 and 4 are used to detect mutations in the katG gene and inhA promoter. QC quality control probe; EC external control probe; BC blank control; NC negative control probe; IC internal control probe; WT wild-type.
    Figure Legend Snippet: The layout of the DNA microarray method module; each detection panel includes 4 detection modules, which can detect two specimens at the same time. Modules 1 and 3 are used to detect mutations in the rpoB gene, and modules 2 and 4 are used to detect mutations in the katG gene and inhA promoter. QC quality control probe; EC external control probe; BC blank control; NC negative control probe; IC internal control probe; WT wild-type.

    Techniques Used: Microarray, Control, Negative Control

    The drug susceptibility test was used as a standard method to evaluate the efficacy of the DNA microarray for detecting RIF and INH resistance and MDR-TB.
    Figure Legend Snippet: The drug susceptibility test was used as a standard method to evaluate the efficacy of the DNA microarray for detecting RIF and INH resistance and MDR-TB.

    Techniques Used: Microarray

    Comparison of the diagnostic efficacy of the DNA microarray method when sputum smear grades were ≤ 1 + and ≥ 2 +
    Figure Legend Snippet: Comparison of the diagnostic efficacy of the DNA microarray method when sputum smear grades were ≤ 1 + and ≥ 2 +

    Techniques Used: Comparison, Diagnostic Assay, Microarray

    Specimen processing procedure: A total of 5,911 sputum smear-positive specimens were collected. After experimental processing, 4148 specimens that were positive with the DNA microarray method and DST were finally included in the study. NTM, nontuberculous mycobacteria ; DST, drug sensitivity test.
    Figure Legend Snippet: Specimen processing procedure: A total of 5,911 sputum smear-positive specimens were collected. After experimental processing, 4148 specimens that were positive with the DNA microarray method and DST were finally included in the study. NTM, nontuberculous mycobacteria ; DST, drug sensitivity test.

    Techniques Used: Microarray

    Pattern diagrams of several common drug-resistant gene mutations detected by the DNA microarray method. The white box is the detection site of the wild-type codon, and the red box is the site of the detected mutant codon. ( a ) rpoB gene Leu511Pro (CTG → CCG); ( b ) rpoB gene Asp516Tyr (GAC → TAC); ( c ) rpoB gene His526Tyr (CAC → TAC); ( d ) rpoB gene Ser531Trp (TCG → TGG); ( e ) rpoB gene Ser531Leu (TCG → TTG); ( f ) katG gene Ser315Thr (AGC → ACC); ( g ) katG gene Ser315Asn (AGC → AAC); ( h ) inhA gene promoter-15 (C → T).
    Figure Legend Snippet: Pattern diagrams of several common drug-resistant gene mutations detected by the DNA microarray method. The white box is the detection site of the wild-type codon, and the red box is the site of the detected mutant codon. ( a ) rpoB gene Leu511Pro (CTG → CCG); ( b ) rpoB gene Asp516Tyr (GAC → TAC); ( c ) rpoB gene His526Tyr (CAC → TAC); ( d ) rpoB gene Ser531Trp (TCG → TGG); ( e ) rpoB gene Ser531Leu (TCG → TTG); ( f ) katG gene Ser315Thr (AGC → ACC); ( g ) katG gene Ser315Asn (AGC → AAC); ( h ) inhA gene promoter-15 (C → T).

    Techniques Used: Microarray, Mutagenesis

    Related Articles

    Microarray:

    Article Title: Emerging Rapid Resistance Testing Methods for Clinical Microbiology Laboratories and Their Potential Impact on Patient Management
    Article Snippet: .. In a recent study, Zhang and coworkers described that CapitalBio DNA microarray (CapitalBio Corp.) could in a mean time of 5.8 hours simultaneously identify Mycobacterium species and detect mutations that confer isoniazid (INH) and rifampicin (RMP) resistance in specimens collected from spinal tuberculosis patients as compared to conventional culture and drug susceptibility testing which took a mean time of 56.8 days [ ]. ..

    Article Title: Gene expression patterns and related pathways in the hearts of rhesus monkeys subjected to prolonged myocardial ischemia.
    Article Snippet: .. The DNA microarray technology and part associated bioinformatics analysis were supported by CapitalBio Corporation Company, Beijing, China. ..

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
    Article Snippet: .. Therefore, the CapitalBio DNA microarray method also needs to increase the detection range to increase the detection rate of drug-resistant TB. ..

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
    Article Snippet: .. Therefore, the CapitalBio DNA microarray method also detects the mutation of these two genes to determine the resistance to INH. ..

    Article Title: Fluorescence microarrays for enzyme-free DNA detection based on web hybrid chain reaction
    Article Snippet: Ultrapure water was supplied through a Millipore water purification system (⩾18 MΩ, Milli-Q, Millipore). .. The DNA microarray were printed by Smart Arrayer (Beijing CapitalBio Co. Ltd.) and scanned by Luxsca-10K/A microarray Scanner (532 nm laser source for Cy3, Beijing CapitalBio Co. Ltd.). .. The integrated DNA Technologies online design tool was used to design and test the hybridization structures of the oligonucleotide sequence.

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
    Article Snippet: .. In addition, we detected all 13 rpoB mutation types that can be detected with the CapitalBio DNA microarray method; among them, Gln513Leu, His526Arg, and Asp516Gly were rarely reported in previous studies , , which illustrates the diversity of the gene pool of RIF-resistant TB strains in Lianyungang. ..

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
    Article Snippet: .. To meet the demand for the rapid and accurate detection of Mtb and drug resistance, CapitalBio developed a DNA microarray gene detection system. .. The CapitalBio DNA microarray method can quickly detect Mtb drug resistance within 6 h in full.

    Mutagenesis:

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
    Article Snippet: .. Therefore, the CapitalBio DNA microarray method also detects the mutation of these two genes to determine the resistance to INH. ..

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study
    Article Snippet: .. In addition, we detected all 13 rpoB mutation types that can be detected with the CapitalBio DNA microarray method; among them, Gln513Leu, His526Arg, and Asp516Gly were rarely reported in previous studies , , which illustrates the diversity of the gene pool of RIF-resistant TB strains in Lianyungang. ..

    other:

    Article Title: Clinical characteristics, common sites and drug resistance profile in culture-confirmed extrapulmonary TB/HIV co-infection patients, Southwest China.
    Article Snippet: Mycobacterium tuberulosis H37Rv was used as the control strain. p-Nitrobenzoic acid PNB) and thiophene-2-carboxylic acid hydrazide (TCH) were first sed for M. tuberculosis identification, while a CapitalBio TM DNA icroarray (CapitalBio Corp.) was used for further identification of pecies/complex levels.



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    The layout of the <t>DNA</t> <t>microarray</t> method module; each detection panel includes 4 detection modules, which can detect two specimens at the same time. Modules 1 and 3 are used to detect mutations in the rpoB gene, and modules 2 and 4 are used to detect mutations in the katG gene and inhA promoter. QC quality control probe; EC external control probe; BC blank control; NC negative control probe; IC internal control probe; WT wild-type.
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    Image Search Results


    In this study, genome-wide DNA methylation of 100 samples from 11 patients was assessed. Each patient had multiple primary small intestinal neuroendocrine tumours (ranging from 2-16 per patient), and a subset of 9 patients had a matched normal small intestinal epithelial sample assessed. A subset of 8 patients also had metastases originating from their SI-NETs (ranging from 1-2 per patient). DNA methylation data was used to assess differential methylation relating to the multifocal tumours, the epigenetic clock was used to assess the ‘timing’ of tumour development and metabolic traits predicted by DNA methylation were compared between samples.

    Journal: bioRxiv

    Article Title: Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes

    doi: 10.1101/2024.12.02.626017

    Figure Lengend Snippet: In this study, genome-wide DNA methylation of 100 samples from 11 patients was assessed. Each patient had multiple primary small intestinal neuroendocrine tumours (ranging from 2-16 per patient), and a subset of 9 patients had a matched normal small intestinal epithelial sample assessed. A subset of 8 patients also had metastases originating from their SI-NETs (ranging from 1-2 per patient). DNA methylation data was used to assess differential methylation relating to the multifocal tumours, the epigenetic clock was used to assess the ‘timing’ of tumour development and metabolic traits predicted by DNA methylation were compared between samples.

    Article Snippet: Genome-wide DNA methylation microarray data was generated on the Illumina iScan System using the Illumina Infinium MethylationEPIC BeadChip according to the manufacturer’s protocol.

    Techniques: Genome Wide, DNA Methylation Assay, Methylation

    (A) Plot of age predictions for normal epithelia samples (green), primary tumours (purple) and metastatic tumours (blue). Chronological age is indicated with the orange points and patients are indicated in order of chronological age. (B) Boxplot of age acceleration difference for the skin and blood clock predictions. (C) Somatic mutation count from tumours correlates with DNA methylation age in the skin and blood clock (p=0.0007).

    Journal: bioRxiv

    Article Title: Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes

    doi: 10.1101/2024.12.02.626017

    Figure Lengend Snippet: (A) Plot of age predictions for normal epithelia samples (green), primary tumours (purple) and metastatic tumours (blue). Chronological age is indicated with the orange points and patients are indicated in order of chronological age. (B) Boxplot of age acceleration difference for the skin and blood clock predictions. (C) Somatic mutation count from tumours correlates with DNA methylation age in the skin and blood clock (p=0.0007).

    Article Snippet: Genome-wide DNA methylation microarray data was generated on the Illumina iScan System using the Illumina Infinium MethylationEPIC BeadChip according to the manufacturer’s protocol.

    Techniques: Mutagenesis, DNA Methylation Assay

    Sociodemographic and sexual characteristics of the incarcerated women in São Paulo, Brazil.

    Journal: Frontiers in Public Health

    Article Title: Prevalence of sexually transmitted infections and human papillomavirus in cervical samples from incarcerated women in São Paulo, Brazil: a retrospective single-center study

    doi: 10.3389/fpubh.2024.1353845

    Figure Lengend Snippet: Sociodemographic and sexual characteristics of the incarcerated women in São Paulo, Brazil.

    Article Snippet: The STI prevalence was determined using a similar DNA microarray system, EUROArray STI (EUROIMMUN, Germany).

    Techniques:

    Prevalence of STIs among the imprisoned women. The y-axis has been segmented in order to display all results. STIs for which all women were negative for have been excluded.

    Journal: Frontiers in Public Health

    Article Title: Prevalence of sexually transmitted infections and human papillomavirus in cervical samples from incarcerated women in São Paulo, Brazil: a retrospective single-center study

    doi: 10.3389/fpubh.2024.1353845

    Figure Lengend Snippet: Prevalence of STIs among the imprisoned women. The y-axis has been segmented in order to display all results. STIs for which all women were negative for have been excluded.

    Article Snippet: The STI prevalence was determined using a similar DNA microarray system, EUROArray STI (EUROIMMUN, Germany).

    Techniques:

    IHC staining of the NQO1 protein on tissue microarray of cervical lesions. (A) NQO1 protein was weakly positive in cervical SCC. (B) NQO1 protein showed diffuse and strong cytoplasmic-positive staining in cervical SCC. (C) NQO1 protein was negative in normal cervical epithelia. (D) NQO1 protein was positive in SCC.

    Journal: BMC Cancer

    Article Title: NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

    doi: 10.1186/1471-2407-14-414

    Figure Lengend Snippet: IHC staining of the NQO1 protein on tissue microarray of cervical lesions. (A) NQO1 protein was weakly positive in cervical SCC. (B) NQO1 protein showed diffuse and strong cytoplasmic-positive staining in cervical SCC. (C) NQO1 protein was negative in normal cervical epithelia. (D) NQO1 protein was positive in SCC.

    Article Snippet: DNA was extracted from paraffin-embedded cervical lesion specimens using the High Pure PCR Template Preparation kit (Cat.11796828001, Roche, Penzberg, Germany), and HPV detection and genotyping were performed using a PCR-based HPV-DNA microarray system (Biomedlab, Seoul, South Korea).

    Techniques: Immunohistochemistry, Microarray, Staining

    The layout of the DNA microarray method module; each detection panel includes 4 detection modules, which can detect two specimens at the same time. Modules 1 and 3 are used to detect mutations in the rpoB gene, and modules 2 and 4 are used to detect mutations in the katG gene and inhA promoter. QC quality control probe; EC external control probe; BC blank control; NC negative control probe; IC internal control probe; WT wild-type.

    Journal: Scientific Reports

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study

    doi: 10.1038/s41598-021-97559-y

    Figure Lengend Snippet: The layout of the DNA microarray method module; each detection panel includes 4 detection modules, which can detect two specimens at the same time. Modules 1 and 3 are used to detect mutations in the rpoB gene, and modules 2 and 4 are used to detect mutations in the katG gene and inhA promoter. QC quality control probe; EC external control probe; BC blank control; NC negative control probe; IC internal control probe; WT wild-type.

    Article Snippet: To meet the demand for the rapid and accurate detection of Mtb and drug resistance, CapitalBio developed a DNA microarray gene detection system.

    Techniques: Microarray, Control, Negative Control

    The drug susceptibility test was used as a standard method to evaluate the efficacy of the DNA microarray for detecting RIF and INH resistance and MDR-TB.

    Journal: Scientific Reports

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study

    doi: 10.1038/s41598-021-97559-y

    Figure Lengend Snippet: The drug susceptibility test was used as a standard method to evaluate the efficacy of the DNA microarray for detecting RIF and INH resistance and MDR-TB.

    Article Snippet: To meet the demand for the rapid and accurate detection of Mtb and drug resistance, CapitalBio developed a DNA microarray gene detection system.

    Techniques: Microarray

    Comparison of the diagnostic efficacy of the DNA microarray method when sputum smear grades were ≤ 1 + and ≥ 2 +

    Journal: Scientific Reports

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study

    doi: 10.1038/s41598-021-97559-y

    Figure Lengend Snippet: Comparison of the diagnostic efficacy of the DNA microarray method when sputum smear grades were ≤ 1 + and ≥ 2 +

    Article Snippet: To meet the demand for the rapid and accurate detection of Mtb and drug resistance, CapitalBio developed a DNA microarray gene detection system.

    Techniques: Comparison, Diagnostic Assay, Microarray

    Specimen processing procedure: A total of 5,911 sputum smear-positive specimens were collected. After experimental processing, 4148 specimens that were positive with the DNA microarray method and DST were finally included in the study. NTM, nontuberculous mycobacteria ; DST, drug sensitivity test.

    Journal: Scientific Reports

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study

    doi: 10.1038/s41598-021-97559-y

    Figure Lengend Snippet: Specimen processing procedure: A total of 5,911 sputum smear-positive specimens were collected. After experimental processing, 4148 specimens that were positive with the DNA microarray method and DST were finally included in the study. NTM, nontuberculous mycobacteria ; DST, drug sensitivity test.

    Article Snippet: To meet the demand for the rapid and accurate detection of Mtb and drug resistance, CapitalBio developed a DNA microarray gene detection system.

    Techniques: Microarray

    Pattern diagrams of several common drug-resistant gene mutations detected by the DNA microarray method. The white box is the detection site of the wild-type codon, and the red box is the site of the detected mutant codon. ( a ) rpoB gene Leu511Pro (CTG → CCG); ( b ) rpoB gene Asp516Tyr (GAC → TAC); ( c ) rpoB gene His526Tyr (CAC → TAC); ( d ) rpoB gene Ser531Trp (TCG → TGG); ( e ) rpoB gene Ser531Leu (TCG → TTG); ( f ) katG gene Ser315Thr (AGC → ACC); ( g ) katG gene Ser315Asn (AGC → AAC); ( h ) inhA gene promoter-15 (C → T).

    Journal: Scientific Reports

    Article Title: Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study

    doi: 10.1038/s41598-021-97559-y

    Figure Lengend Snippet: Pattern diagrams of several common drug-resistant gene mutations detected by the DNA microarray method. The white box is the detection site of the wild-type codon, and the red box is the site of the detected mutant codon. ( a ) rpoB gene Leu511Pro (CTG → CCG); ( b ) rpoB gene Asp516Tyr (GAC → TAC); ( c ) rpoB gene His526Tyr (CAC → TAC); ( d ) rpoB gene Ser531Trp (TCG → TGG); ( e ) rpoB gene Ser531Leu (TCG → TTG); ( f ) katG gene Ser315Thr (AGC → ACC); ( g ) katG gene Ser315Asn (AGC → AAC); ( h ) inhA gene promoter-15 (C → T).

    Article Snippet: To meet the demand for the rapid and accurate detection of Mtb and drug resistance, CapitalBio developed a DNA microarray gene detection system.

    Techniques: Microarray, Mutagenesis