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franz diffusion cell system  (Logan Instruments CORP)


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    Structured Review

    Logan Instruments CORP franz diffusion cell system
    Experimental workflow of the comparative IVPT study. Two commercial diclofenac gels, Voltaren® and Olfen®, were evaluated using <t>Franz</t> <t>diffusion</t> <t>cells</t> and two structurally distinct barrier models: Strat-M® and the HaCaT construct. The main permeation outputs included cumulative permeated amount, Jss, t lag, and Kp. The study was designed to assess whether the selection of a barrier model influences the comparative interpretation of formulation performance. Created in BioRender.com .
    Franz Diffusion Cell System, supplied by Logan Instruments CORP, used in various techniques. Bioz Stars score: 96/100, based on 437 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/diffusion/Diffusion/pmc13684325-127-7-14
    Average 96 stars, based on 437 article reviews
    franz diffusion cell system - by Bioz Stars, 2026-11
    96/100 stars

    Images

    1) Product Images from "Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M ® and a HaCaT-based epidermal construct"

    Article Title: Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M ® and a HaCaT-based epidermal construct

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2026.1934405

    Experimental workflow of the comparative IVPT study. Two commercial diclofenac gels, Voltaren® and Olfen®, were evaluated using Franz diffusion cells and two structurally distinct barrier models: Strat-M® and the HaCaT construct. The main permeation outputs included cumulative permeated amount, Jss, t lag, and Kp. The study was designed to assess whether the selection of a barrier model influences the comparative interpretation of formulation performance. Created in BioRender.com .
    Figure Legend Snippet: Experimental workflow of the comparative IVPT study. Two commercial diclofenac gels, Voltaren® and Olfen®, were evaluated using Franz diffusion cells and two structurally distinct barrier models: Strat-M® and the HaCaT construct. The main permeation outputs included cumulative permeated amount, Jss, t lag, and Kp. The study was designed to assess whether the selection of a barrier model influences the comparative interpretation of formulation performance. Created in BioRender.com .

    Techniques Used: Diffusion-based Assay, Construct, Selection, Formulation

    Schematic representation of the two barrier systems as mounted in the Franz diffusion cell. In both panels, the formulation is applied to the donor side (top), and the receptor medium lies below. Left: the Strat-M® synthetic membrane, comprising two polyethersulfone layers of high diffusional resistance over a more permeable polyolefin support, with synthetic lipids distributed throughout the porous structure; this depiction follows the manufacturer’s description of the membrane. Right: the HaCaT construct, comprising keratinocytes cultured at the air–liquid interface on a porous PET insert membrane. The right-hand panel is a generic depiction of this class of model and not a representation of the construct used here: no cross-sectional imaging was performed, multilayer architecture was not confirmed, and neither the number nor the arrangement of the cell layers shown was measured in this study. No stratum corneum is depicted, and none was demonstrated. The drawing is not to scale and is intended solely to contrast the architectural principles of the two model types. Created in BioRender.com .
    Figure Legend Snippet: Schematic representation of the two barrier systems as mounted in the Franz diffusion cell. In both panels, the formulation is applied to the donor side (top), and the receptor medium lies below. Left: the Strat-M® synthetic membrane, comprising two polyethersulfone layers of high diffusional resistance over a more permeable polyolefin support, with synthetic lipids distributed throughout the porous structure; this depiction follows the manufacturer’s description of the membrane. Right: the HaCaT construct, comprising keratinocytes cultured at the air–liquid interface on a porous PET insert membrane. The right-hand panel is a generic depiction of this class of model and not a representation of the construct used here: no cross-sectional imaging was performed, multilayer architecture was not confirmed, and neither the number nor the arrangement of the cell layers shown was measured in this study. No stratum corneum is depicted, and none was demonstrated. The drawing is not to scale and is intended solely to contrast the architectural principles of the two model types. Created in BioRender.com .

    Techniques Used: Diffusion-based Assay, Formulation, Membrane, Construct, Cell Culture, Imaging

    Related Articles

    Formulation:

    Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles
    Article Snippet: The filtered solutions were analyzed thrice for each formulation using HPLC (Waters e2695; Milford, MA, USA) (n = 3). .. Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA). ..

    Permeability:

    Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles
    Article Snippet: The filtered solutions were analyzed thrice for each formulation using HPLC (Waters e2695; Milford, MA, USA) (n = 3). .. Each formulation (NM, NM-HA, and NM-HON) and free MEL were analyzed using a DHC-6TD permeability testing system with a PB-M (Logan Instruments, Somerset, NJ, USA). ..

    Diffusion-based Assay:

    Article Title: In Vitro Tyrosinase Inhibitory Activity of Eleutherine bulbosa Bulb Extract and Characterization of Its Liposomal Delivery System
    Article Snippet: .. Franz diffusion cells (Model FDC-6; Logan Instruments Corp., Somerset, NJ, USA) were used to evaluate the in vitro release and transdermal permeation of the extract. ..

    Article Title: Engineering of sesamol-integrated polymeric nanoparticles for enhanced therapeutic outcomes in cancer and cerebral ischemia
    Article Snippet: The objective of this research was to improve the brain bioavailability of Sesamol (SAL) via formulating novel-chitosan (CHIT)-coated PLGA-nanoparticles and quantifying SAL using a novel LC-MS/MS analytical approach.. The approach was evaluated for its potential in treating ischemic brain injury and colorectal cancer.. PLGA-based nanoparticles encapsulating sesamol (NPs) were produced through the emulsion-based solvent evaporation approach, followed by surface coating with chitosan.

    Article Title: Enhanced follicular delivery of minoxidil to human scalp skin using cetosomal formulation.
    Article Snippet: Background: Androgenetic alopecia (AGA) is a common condition marked by progressive hair follicle miniaturization, for which topical minoxidil remains a first-line therapy.. However, conventional hydroalcoholic formulations are associated with poor scalp retention, rapid drug loss, and local irritation.. This study evaluated the follicular targeting, skin retention, and mechanistic behavior of a cetosomal minoxidil formulation.

    Article Title: Development and Characterization of Shikonin-Loaded NLC with Enhanced Photostability in Hydrogel-Based Dermal Patch
    Article Snippet: .. Membrane Retention and Permeation Study of Hydrogel-Based Dermal Patch Containing Shikonin-Loaded NLC The in vitro membrane retention and permeation study was evaluated using Franz diffusion cells (Logan Instruments, Somerset, NJ, USA) with some modifications [41]. .. This study was to investigate the permeation and retention of shikonin released from a hydrogel dermal patch containing shikonin-loaded NLC through the Strat-M membrane (Strat-M EMD Millipore, Burlington, MA, USA).

    Article Title: Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M ® and a HaCaT-based epidermal construct
    Article Snippet: .. Permeation experiments were performed using an automated Franz diffusion cell system (Logan System 912-6; Logan Instruments Corp., Somerset, NJ, United States) equipped with vertical glass diffusion cells with a diffusion area of 3.14 cm 2 and a receptor compartment volume of 15 mL. ..

    In Vitro:

    Article Title: In Vitro Tyrosinase Inhibitory Activity of Eleutherine bulbosa Bulb Extract and Characterization of Its Liposomal Delivery System
    Article Snippet: .. Franz diffusion cells (Model FDC-6; Logan Instruments Corp., Somerset, NJ, USA) were used to evaluate the in vitro release and transdermal permeation of the extract. ..

    Article Title: Development and Characterization of Shikonin-Loaded NLC with Enhanced Photostability in Hydrogel-Based Dermal Patch
    Article Snippet: .. Membrane Retention and Permeation Study of Hydrogel-Based Dermal Patch Containing Shikonin-Loaded NLC The in vitro membrane retention and permeation study was evaluated using Franz diffusion cells (Logan Instruments, Somerset, NJ, USA) with some modifications [41]. .. This study was to investigate the permeation and retention of shikonin released from a hydrogel dermal patch containing shikonin-loaded NLC through the Strat-M membrane (Strat-M EMD Millipore, Burlington, MA, USA).

    Ex Vivo:

    Article Title: Enhanced follicular delivery of minoxidil to human scalp skin using cetosomal formulation.
    Article Snippet: Background: Androgenetic alopecia (AGA) is a common condition marked by progressive hair follicle miniaturization, for which topical minoxidil remains a first-line therapy.. However, conventional hydroalcoholic formulations are associated with poor scalp retention, rapid drug loss, and local irritation.. This study evaluated the follicular targeting, skin retention, and mechanistic behavior of a cetosomal minoxidil formulation.

    Membrane:

    Article Title: Development and Characterization of Shikonin-Loaded NLC with Enhanced Photostability in Hydrogel-Based Dermal Patch
    Article Snippet: .. Membrane Retention and Permeation Study of Hydrogel-Based Dermal Patch Containing Shikonin-Loaded NLC The in vitro membrane retention and permeation study was evaluated using Franz diffusion cells (Logan Instruments, Somerset, NJ, USA) with some modifications [41]. .. This study was to investigate the permeation and retention of shikonin released from a hydrogel dermal patch containing shikonin-loaded NLC through the Strat-M membrane (Strat-M EMD Millipore, Burlington, MA, USA).

    Automated:

    Article Title: Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M ® and a HaCaT-based epidermal construct
    Article Snippet: .. Permeation experiments were performed using an automated Franz diffusion cell system (Logan System 912-6; Logan Instruments Corp., Somerset, NJ, United States) equipped with vertical glass diffusion cells with a diffusion area of 3.14 cm 2 and a receptor compartment volume of 15 mL. ..

    Glass:

    Article Title: Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M ® and a HaCaT-based epidermal construct
    Article Snippet: .. Permeation experiments were performed using an automated Franz diffusion cell system (Logan System 912-6; Logan Instruments Corp., Somerset, NJ, United States) equipped with vertical glass diffusion cells with a diffusion area of 3.14 cm 2 and a receptor compartment volume of 15 mL. ..



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    Image Search Results


    Experimental workflow of the comparative IVPT study. Two commercial diclofenac gels, Voltaren® and Olfen®, were evaluated using Franz diffusion cells and two structurally distinct barrier models: Strat-M® and the HaCaT construct. The main permeation outputs included cumulative permeated amount, Jss, t lag, and Kp. The study was designed to assess whether the selection of a barrier model influences the comparative interpretation of formulation performance. Created in BioRender.com .

    Journal: Frontiers in Pharmacology

    Article Title: Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M ® and a HaCaT-based epidermal construct

    doi: 10.3389/fphar.2026.1934405

    Figure Lengend Snippet: Experimental workflow of the comparative IVPT study. Two commercial diclofenac gels, Voltaren® and Olfen®, were evaluated using Franz diffusion cells and two structurally distinct barrier models: Strat-M® and the HaCaT construct. The main permeation outputs included cumulative permeated amount, Jss, t lag, and Kp. The study was designed to assess whether the selection of a barrier model influences the comparative interpretation of formulation performance. Created in BioRender.com .

    Article Snippet: Permeation experiments were performed using an automated Franz diffusion cell system (Logan System 912-6; Logan Instruments Corp., Somerset, NJ, United States) equipped with vertical glass diffusion cells with a diffusion area of 3.14 cm 2 and a receptor compartment volume of 15 mL.

    Techniques: Diffusion-based Assay, Construct, Selection, Formulation

    Schematic representation of the two barrier systems as mounted in the Franz diffusion cell. In both panels, the formulation is applied to the donor side (top), and the receptor medium lies below. Left: the Strat-M® synthetic membrane, comprising two polyethersulfone layers of high diffusional resistance over a more permeable polyolefin support, with synthetic lipids distributed throughout the porous structure; this depiction follows the manufacturer’s description of the membrane. Right: the HaCaT construct, comprising keratinocytes cultured at the air–liquid interface on a porous PET insert membrane. The right-hand panel is a generic depiction of this class of model and not a representation of the construct used here: no cross-sectional imaging was performed, multilayer architecture was not confirmed, and neither the number nor the arrangement of the cell layers shown was measured in this study. No stratum corneum is depicted, and none was demonstrated. The drawing is not to scale and is intended solely to contrast the architectural principles of the two model types. Created in BioRender.com .

    Journal: Frontiers in Pharmacology

    Article Title: Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M ® and a HaCaT-based epidermal construct

    doi: 10.3389/fphar.2026.1934405

    Figure Lengend Snippet: Schematic representation of the two barrier systems as mounted in the Franz diffusion cell. In both panels, the formulation is applied to the donor side (top), and the receptor medium lies below. Left: the Strat-M® synthetic membrane, comprising two polyethersulfone layers of high diffusional resistance over a more permeable polyolefin support, with synthetic lipids distributed throughout the porous structure; this depiction follows the manufacturer’s description of the membrane. Right: the HaCaT construct, comprising keratinocytes cultured at the air–liquid interface on a porous PET insert membrane. The right-hand panel is a generic depiction of this class of model and not a representation of the construct used here: no cross-sectional imaging was performed, multilayer architecture was not confirmed, and neither the number nor the arrangement of the cell layers shown was measured in this study. No stratum corneum is depicted, and none was demonstrated. The drawing is not to scale and is intended solely to contrast the architectural principles of the two model types. Created in BioRender.com .

    Article Snippet: Permeation experiments were performed using an automated Franz diffusion cell system (Logan System 912-6; Logan Instruments Corp., Somerset, NJ, United States) equipped with vertical glass diffusion cells with a diffusion area of 3.14 cm 2 and a receptor compartment volume of 15 mL.

    Techniques: Diffusion-based Assay, Formulation, Membrane, Construct, Cell Culture, Imaging