free mel (Logan Instruments CORP)
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Free Mel, supplied by Logan Instruments CORP, used in various techniques. Bioz Stars score: 96/100, based on 434 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/diffusion/Diffusion/pmc13622936-135-7-20
Average 96 stars, based on 434 article reviews
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1) Product Images from "Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles"
Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles
Journal: International Journal of Nanomedicine
doi: 10.2147/IJN.S618075
Figure Legend Snippet: Formulation Compositions for the Preparation of NM, NM-HA, and NM-HON by ABN
Techniques Used: Formulation
Figure Legend Snippet: Comparative stability of MEL, neutralized MEL (NM) and NM-loaded formulations (NM-HA, and NM-HON) in pH 7.4 PBS (n = 3). **p < 0.01, ***p < 0.001. ****p<0.0001 One-way ANOVA compared with MEL.
Techniques Used: Stability
Figure Legend Snippet: Solid-state stability of freeze-dried NM, NM-HA, and NM-HON at 25 °C and 70 % RH (n = 3). *p<0.05, **p < 0.01, ****p<0.0001 One-way ANOVA compared with MEL.
Techniques Used: Stability
Figure Legend Snippet: FE-SEM images of MEL ( a ), HA ( b ), HOC ( c ), NM ( d ), NM-HA ( e ), and NM-HON ( f ).
Techniques Used:
Figure Legend Snippet: Fourier transform-infrared (FT-IR) spectra ( a ), differential scanning calorimetry (DSC) thermograms ( b ), and high power X- ray diffraction (HP-XRD) patterns ( c) of MEL, NM, NM-HA, NM-HON, and raw materials.
Techniques Used: Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry
Figure Legend Snippet: In vitro permeability profiles of MEL, NM, NM-HA, and NM-HON using permeation barrier membrane (PB-M) in pH 7.4 PBS (n = 3). **p < 0.01, ***p < 0.001. ****p<0.0001 One-Way ANOVA compared with MEL.
Techniques Used: In Vitro, Permeability, Membrane
Figure Legend Snippet: In vitro release profiles of MEL, NM, NM-HA, and NM-HON in pH 7.4 PBS ( a ), pH 5.2 ABS ( b ), and pH 7.4 PBS with 10 mM GSH ( c ) (n = 3). *p < 0.05, **p<0.01, ***p < 0.001. ****p<0.0001 One-way ANOVA compared with MEL.
Techniques Used: In Vitro
Figure Legend Snippet: In vitro cytotoxicity of MEL, NM, NM-HA, and NM-HON in ARPE-19 normal cells ( a ) and WERI-Rb-1 cancer cells ( b ) after incubation for 24 h (n = 3). *p < 0.05, **p<0.01, ***p < 0.001. ****p<0.0001 One-way ANOVA compared with MEL.
Techniques Used: In Vitro, Incubation
Related Articles
Formulation:Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles Article Snippet: The filtered solutions were analyzed thrice for each formulation using HPLC (Waters e2695; Milford, MA, USA) (n = 3). .. Each formulation (NM, NM-HA, and NM-HON) and Permeability:Article Title: Improved Physicochemical Stability and Retinoblastoma Anticancer Activity of Salt-Caged Acid–Base Neutralized Melphalan Loaded in L-Glutathione and pH Responsive Fattigated Nanoparticles Article Snippet: The filtered solutions were analyzed thrice for each formulation using HPLC (Waters e2695; Milford, MA, USA) (n = 3). .. Each formulation (NM, NM-HA, and NM-HON) and Diffusion-based Assay:Article Title: Engineering of sesamol-integrated polymeric nanoparticles for enhanced therapeutic outcomes in cancer and cerebral ischemia Article Snippet: The objective of this research was to improve the brain bioavailability of Sesamol (SAL) via formulating novel-chitosan (CHIT)-coated PLGA-nanoparticles and quantifying SAL using a novel LC-MS/MS analytical approach.. The approach was evaluated for its potential in treating ischemic brain injury and colorectal cancer.. PLGA-based nanoparticles encapsulating sesamol (NPs) were produced through the emulsion-based solvent evaporation approach, followed by surface coating with chitosan. Article Title: Development of antifungal albumin-based films for use as catheter dressing. Article Snippet: The fungal infection caused by Candida albicans in central venous catheters is severe, and patient survival is strongly linked to early source control of the medical devices.. To mitigate this problem, egg albumin-based films containing clioquinol were produced through a casting method to develop an antifungal barrier for catheters.. To enhance the films' mechanical properties, glycerol was added as a plasticizer. Article Title: Enhanced follicular delivery of minoxidil to human scalp skin using cetosomal formulation. Article Snippet: Background: Androgenetic alopecia (AGA) is a common condition marked by progressive hair follicle miniaturization, for which topical minoxidil remains a first-line therapy.. However, conventional hydroalcoholic formulations are associated with poor scalp retention, rapid drug loss, and local irritation.. This study evaluated the follicular targeting, skin retention, and mechanistic behavior of a cetosomal minoxidil formulation. Article Title: Q3 equivalence in semisolids: integrating alkane fingerprinting with rheological analysis for crisaborole ointment Article Snippet: 1 R&D Centre, Sinomune Pharmaceutical Co., Ltd, Wuxi 214194, Jiangsu, China 2 Post-Doc Research Scholar, Department of Pharmaceutics, Manipur International University, Imphal 795140, Manipur, India 3 Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, Hunan, China Abstract The development of generic semisolid formulations requires rigorous rheological characterisation to ensure pharmaceutical equivalence with reference-listed products.. This study systematically optimised critical rheological parameters, including flow curves, yield stress, linear viscoelasticity, and creep tests, for Crisaborole (CB) Ointment 2%, in alignment with regulatory guidelines.. Hydrocarbon profiling by gas chromatography was performed to determine the deformatulation of the ointment base. Ex Vivo:Article Title: Enhanced follicular delivery of minoxidil to human scalp skin using cetosomal formulation. Article Snippet: Background: Androgenetic alopecia (AGA) is a common condition marked by progressive hair follicle miniaturization, for which topical minoxidil remains a first-line therapy.. However, conventional hydroalcoholic formulations are associated with poor scalp retention, rapid drug loss, and local irritation.. This study evaluated the follicular targeting, skin retention, and mechanistic behavior of a cetosomal minoxidil formulation. In Vitro:Article Title: Q3 equivalence in semisolids: integrating alkane fingerprinting with rheological analysis for crisaborole ointment Article Snippet: 1 R&D Centre, Sinomune Pharmaceutical Co., Ltd, Wuxi 214194, Jiangsu, China 2 Post-Doc Research Scholar, Department of Pharmaceutics, Manipur International University, Imphal 795140, Manipur, India 3 Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, Hunan, China Abstract The development of generic semisolid formulations requires rigorous rheological characterisation to ensure pharmaceutical equivalence with reference-listed products.. This study systematically optimised critical rheological parameters, including flow curves, yield stress, linear viscoelasticity, and creep tests, for Crisaborole (CB) Ointment 2%, in alignment with regulatory guidelines.. Hydrocarbon profiling by gas chromatography was performed to determine the deformatulation of the ointment base. |