dba 2jrj mice (Janvier Labs)
86
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Janvier Labs
dba 2jrj mice
Dba 2jrj Mice, supplied by Janvier Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dba/1+dba+mice/pm42270907-35-2-7
Average 86 stars, based on 1 article reviews
Dba 2jrj Mice, supplied by Janvier Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dba/1+dba+mice/pm42270907-35-2-7
Average 86 stars, based on 1 article reviews
dba 2jrj mice - by Bioz Stars,
2026-10
86/100 stars
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Sequencing:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. Endpoint Dilution Assay:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. Serial Dilution:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. Enzyme-linked Immunosorbent Assay:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. Comparison:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. MANN-WHITNEY:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. Isolation:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. Virus:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. Injection:Article Title: Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis Article Snippet: Five to six-week-old Article Title: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development. Article Snippet: 50 μL of Working Detection Solution (19 parts of Cell Assay Buffer, five parts of Substrate Reagent 1 and one-part Substrate Reagent 2, DiscoverX PathHunter detection kit 93-001) were added followed by a 1-hour incubation at room temperature in the dark for the reaction to occur. |
![Phenotypic Characterization of Collagen Induced Arthritis <t>in</t> <t>DBA/1J</t> Mice. DBA/1J mice were immunized with bovine type II collagen (N = 11–55; arthritic: n = 6–18; non-arthritic: n = 5–37) or PBS (N = 4–14). A) Representative photographs and E) 3D-rendered micro-CT radiographs of arthritic (red arrow = bone erosion), non-arthritic, and PBS-injected mouse hind limbs. Changes in B) clinical arthritis score, C) anti-bovine type II collagen (CII) IgG and D) anti-mouse CII IgG over time. Dashed line represents the antibody positivity cut-off, indicating the limit of detection. F) Hind limb bone mineral density and G) bone mineral density of bCII-immunized fore and hind limbs over time. H) Pain-like behaviour at day 47 post primary immunization. Graphs show the median [IQR], with each symbol in F-H) representing an individual mouse. For B-D), statistical analysis was performed using a mixed effects model with the Geisser-Greenhouse correction and Tukey's multiple comparisons test, with resulting p-values shown in the graphs. Kruskal-Wallis with Dunn's multiple comparisons test was used for F) and H), and the resulting p-values were p = 0.0008 and p = 0.0003 respectively, with p-values for pairwise comparisons indicated on the graphs. For G), a Spearman correlation coefficient (r) was calculated and p < 0.05 was considered significant.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_0342/pmc12810342/pmc12810342__gr1.jpg)
![Collagen Induced Arthritis Histopathology in DBA/1J Metatarsophalangeal Joints. Representative A) hematoxylin + eosin and B) toluidine blue micrographs of joints from DBA/1J mice immunized with bovine type II collagen (arthritic: N = 9; non-arthritic: N = 11), or PBS (N = 14). The first image in each row was obtained at 140× magnification (scale bar = 300 μm). Adjacent images show enlargement of the outlined regions, obtained at 400× magnification (scale bar = 100 μm). Histopathological features: pannus (yellow arrowheads) with bone marrow penetration (green asterisk), joint debris (green arrows), synovitis (black asterisk), proteoglycan loss (yellow oval), and cartilage erosion (red arrowheads). C) Four histopathology parameters, synovial inflammation, bone erosion, proteoglycan loss, and cartilage erosion, were each scored out of 3. Graphs show the median [IQR], with each symbol representing an individual mouse. Statistical analysis was performed using Kruskal-Wallis with Dunn's multiple comparisons test, and the resulting p-values were p = 0.0013, p = 0.0003, p = 0.0016, and p = 0.0003 respectively, with p-values for pairwise comparisons indicated on the graphs.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_0342/pmc12810342/pmc12810342__gr2.jpg)
![Citrullinated and Homocitrullinated Proteins/Peptides are Present in DBA/1J Metatarsophalangeal Joints. A) Representative hematoxylin + eosin (H&E) at 80× magnification and immunofluorescent micrographs at 20× magnification of joints from DBA/1J mice immunized with bovine type II collagen (arthritic: N = 9; non-arthritic: N = 10) or PBS (N = 9). Scale bars represent 500 μm. Max projections of Z-stacks show nuclei (DAPI; blue), citrullinated proteins/peptides (CitP; green), and homocitrullinated proteins/peptides (HomoCitP; red). Corrected total fluorescence intensity for B) CitP and C) HomoCitP in three joint structures: bone marrow, synovium, and cartilage. Graphs show the median [IQR], with each symbol representing an individual mouse. Statistical analysis was performed using Kruskal-Wallis with Dunn's multiple comparisons test, and the resulting p-values were p = 0.0046, p = 0.0084, p = 0.4076, p = 0.0143, p = 0.0136, and p = 0.1733 respectively, with p-values for pairwise comparisons indicated on the graphs. ns: not significant.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_0342/pmc12810342/pmc12810342__gr3.jpg)
![RA-Specific Serum IgG Antibodies in DBA/1J Mice. Sera were collected biweekly from DBA/1J mice immunized with bovine type II collagen (bCII) (arthritic: N = 9–18; non-arthritic: N = 17–37), or PBS (N = 14) and tested via indirect ELISA for A) anti-CitP, and B) anti-HomoCitP IgG antibodies. Graphs show the median [IQR] for each group, with a cut-off indicating the limit of detection (dashed line). Statistical analysis was performed using a mixed effects model with the Geisser-Greenhouse correction and Tukey's multiple comparisons test. The resulting p-values are indicated on the graphs.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_0342/pmc12810342/pmc12810342__gr6.jpg)