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il-4  (BioCarta)

 
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    BioCarta il-4
    Il 4, supplied by BioCarta, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/constrained+non-negative+matrix+factorization+(cnmfe)+algorithm/il+4/pm39375446-89-35-35
    Average 90 stars, based on 1 article reviews
    il-4 - by Bioz Stars, 2026-10
    90/100 stars

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    Article Title: Scalable, compressed phenotypic screening using pooled perturbations.
    Article Snippet: Nature Biotechnology Article https://doi.org/10.1038/s41587-024-02403-z a c Significant ligand e ects (P < 0.01) in both CS plates Single-ligand validation design g TCGA pancreatic cancer (PAAD) tumors (n = 182) Log-rank test, P = 0.53 High Biocarta IL-4 Low Biocarta IL-4 log-rank test, P = 0.27 High Lu et al. IL-4 signaling Low Lu et al. IL-4 signaling log-rank test, P = 0.41 High Reactome IL-4 signaling Low Reactome IL-4 signaling log-rank test, P = 0.02 High PDAC IL-4/IL-13 Low PDAC IL-4/IL-13 % Su rv iv al 100 80 60 40 20 0 Reactome IL-4/IL-13 (111 genes) Biocarta IL-4 pathway (11 genes) 133 cNMF: PDAC IL-4/IL-13 GEP (133 genes) Lu et al. IL-4 signaling (91 genes) * d scRNA-seq + 12-plex antibody hashing TNF TGFβ1 IFNγ R = 5 (replicates) P = 4.75 (mean pool size) Profile the impact of macrophagederived ligands on PDAC organoid cell states PDAC organoids treated for 7 days 68 cell signaling ligands at curated concentrations R = 4 (replicates) Compressed screen Landmark perturbations Gene expression program (GEP) discovery and deconvolution 2 randomly pooled plates Integrate plates (n = 16,543 cells) and identify GEPs (tumor response modules) by consensus non-negative matrix factorization (cNMF) Perform regularized linear model deconvolution Ligands G EP s How do environmental ligands impact tumor cell state?



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    constrained non-negative matrix factorization (cnmfe) algorithm  (MathWorks Inc)
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    MathWorks Inc constrained non-negative matrix factorization (cnmfe) algorithm
    KEY RESOURCES TABLE
    Constrained Non Negative Matrix Factorization (Cnmfe) Algorithm, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/constrained+non-negative+matrix+factorization+(cnmfe)+algorithm/pmc09210496-506-5-12
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    KEY RESOURCES TABLE

    Journal: Cell reports

    Article Title: Neural circuit pathology driven by Shank3 mutation disrupts social behaviors

    doi: 10.1016/j.celrep.2022.110906

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: We then implemented the constrained non-negative matrix factorization (CNMFe) algorithm written in MATLAB (Mathworks) scripts for simultaneous denoising, deconvolving, and demixing of Ca 2+ signals as well as automatic cell identification ( ).

    Techniques: Virus, Purification, Plasmid Preparation, Recombinant, Adhesive, Electron Microscopy, Software, Optogenetics, Imaging, Microscopy, Hood, Real-time Polymerase Chain Reaction, Injection, Patch Clamp