Review



compound e  (Tocris)


Bioz Verified Symbol Tocris is a verified supplier
Bioz Manufacturer Symbol Tocris manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 95
      Buy from Supplier

    Structured Review

    Tocris compound e
    Compound E, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 33 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Compound+E/pmc07655657-32-74-76
    Average 95 stars, based on 33 article reviews
    compound e - by Bioz Stars, 2026-11
    95/100 stars

    Images

    Related Articles

    other:

    Article Title: Deep learning modeling of rare noncoding genetic variants in human motor neurons defines CCDC146 as a therapeutic target for ALS
    Article Snippet: On day 19 motor neuron progenitors were split with accutase onto to matrigel-coated plates and the medium was replaced with neural medium supplemented with RA 0.5 μm, PMN 0.1 μm, compound E 0.1 μm (Cpd E, Tocris), BDNF 10ng/mL, CNTF 10ng/mL and IGF 10ng/mL until day 28.

    Article Title: Capture of Human Neuromesodermal and Posterior Neural Tube Axial Stem Cells
    Article Snippet: The next day, the medium was replaced with differentiation medium consisting of a 1:1 mixture of DMEM/F12 and Neurobasal-A medium, 1X B27, 1X N2, 0.1 μM Retinoic acid (RA) (Sigma), 100 ng/ml SHH (Peprotech), 100 μM cAMP (Sigma), 10 ng/ml GDNF (Peprotech), 10 ng/ml BDNF (Peprotech), 10 ng/ml IGF (Peprotech), and 0.1 μM Compound E (Biotechne).

    Isolation:

    Article Title: Methods and systems for screening therapeutic compositions for treating age-related macular degeneration
    Article Snippet: .. TABLE 1 Step Description 1 Grow monolayers of pigmented RPE 2 Place cells in hypoxic O2 environment for a period of time to induce exosome release 3 Add test compound (e.g., drug) to be tested, incubate for a period of time 4 Collect conditioned media with exosomes 5 Isolate exosomes by any appropriate method (eg., polyethylene glycol precipitation, exosome isolation kit, etc.) .. 6 Measure protein in isolated exosomes (any appropriate method to measure, e.g., direct 260/280 absorbance) 7 Compare exosome protein amounts between drug treated and control media (or compare exosome protein amounts between drug treated media and a predetermined threshold) In certain embodiments, the RPE cells must be pigmented, so the cells may be left undisturbed at confluence for a period of time, e.g., minimum of 2-4 months.



    Similar Products

    ferroptosis  (TargetMol)
    96
    TargetMol ferroptosis
    Ferroptosis, supplied by TargetMol, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Ferroptosis+Compound+Library/pm42896314-137-8-21
    Average 96 stars, based on 1 article reviews
    ferroptosis - by Bioz Stars, 2026-11
    96/100 stars
    		  Buy from Supplier
    trillin standard compounds  (Shanghai Yuanye Biotechnology)
    86
    Shanghai Yuanye Biotechnology trillin standard compounds
    Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of <t>trillin</t> mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.
    Trillin Standard Compounds, supplied by Shanghai Yuanye Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/compounds+standard+trillin/pmc13123502-43-3-15
    Average 86 stars, based on 1 article reviews
    trillin standard compounds - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    compound c  (MedChemExpress)
    98
    MedChemExpress compound c
    Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of <t>trillin</t> mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.
    Compound C, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Dorsomorphin/pm42906651-59-0-4
    Average 98 stars, based on 1 article reviews
    compound c - by Bioz Stars, 2026-11
    98/100 stars
    		  Buy from Supplier
    organoid based drug screening  (Selleck Chemicals)
    94
    Selleck Chemicals organoid based drug screening
    Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of <t>trillin</t> mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.
    Organoid Based Drug Screening, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Epigenetics+Compound+Library/pmc13683295-285-4-13
    Average 94 stars, based on 1 article reviews
    organoid based drug screening - by Bioz Stars, 2026-11
    94/100 stars
    		  Buy from Supplier
    drug screen  (TargetMol)
    94
    TargetMol drug screen
    Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of <t>trillin</t> mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.
    Drug Screen, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Cell+Cycle+Compound+Library/pm42901431-305-15-20
    Average 94 stars, based on 1 article reviews
    drug screen - by Bioz Stars, 2026-11
    94/100 stars
    		  Buy from Supplier
    chemical compound  (Akoya Biosciences)
    99
    Akoya Biosciences chemical compound

    Chemical Compound, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Opal+480/pmc13682713-71-0-6
    Average 99 stars, based on 1 article reviews
    chemical compound - by Bioz Stars, 2026-11
    99/100 stars
    		  Buy from Supplier
    endoplasmic reticulum er stress  (TargetMol)
    94
    TargetMol endoplasmic reticulum er stress

    Endoplasmic Reticulum Er Stress, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Endoplasmic+Reticulum+Stress+Compound+Library/pm42896314-137-3-21
    Average 94 stars, based on 1 article reviews
    endoplasmic reticulum er stress - by Bioz Stars, 2026-11
    94/100 stars
    		  Buy from Supplier
    compound e  (Tocris)
    94
    Tocris compound e

    Compound E, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Compound+E/pm42894639-125-155-157
    Average 94 stars, based on 1 article reviews
    compound e - by Bioz Stars, 2026-11
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of trillin mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.

    Journal: Synthetic and Systems Biotechnology

    Article Title: Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant Paris polyphylla

    doi: 10.1016/j.synbio.2026.04.002

    Figure Lengend Snippet: Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of trillin mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.

    Article Snippet: Diosgenin, pennogenin, and trillin standard compounds were purchased from Chengdu Push Biotechnology Co., Ltd., and Shanghai Yuanye Biotechnology Co., Ltd. (China).

    Techniques: Liquid Chromatography with Mass Spectroscopy, Transferring, In Vitro, Activity Assay, Recombinant, Control, Expressing, Plasmid Preparation, Tandem Mass Spectroscopy

    Transient expression and characterization of Pp UGTs in Nicotiana benthamiana . ( a ) UHPLC-MS traces of the trillin formation in N. benthamiana leaf extracts transiently expressing UGT91BP2 and UGT703R1–3 with the infiltration of diosgenin substrate, compared to trillin authentic standard and empty vector control. Q1: parent ion; Q3: daughter ion. ( b ) Confocal microscopic images of the localization of UGT91BP2-GFP, UGT703R1-GFP, UGT703R2-GFP and UGT703R3-GFP in N. benthamiana leaves. DAPI (a nuclear-specific fluorescence dye) acts as a nucleus indicator. Scale bars, 20 μm. The experiments were repeated two times with similar results.

    Journal: Synthetic and Systems Biotechnology

    Article Title: Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant Paris polyphylla

    doi: 10.1016/j.synbio.2026.04.002

    Figure Lengend Snippet: Transient expression and characterization of Pp UGTs in Nicotiana benthamiana . ( a ) UHPLC-MS traces of the trillin formation in N. benthamiana leaf extracts transiently expressing UGT91BP2 and UGT703R1–3 with the infiltration of diosgenin substrate, compared to trillin authentic standard and empty vector control. Q1: parent ion; Q3: daughter ion. ( b ) Confocal microscopic images of the localization of UGT91BP2-GFP, UGT703R1-GFP, UGT703R2-GFP and UGT703R3-GFP in N. benthamiana leaves. DAPI (a nuclear-specific fluorescence dye) acts as a nucleus indicator. Scale bars, 20 μm. The experiments were repeated two times with similar results.

    Article Snippet: Diosgenin, pennogenin, and trillin standard compounds were purchased from Chengdu Push Biotechnology Co., Ltd., and Shanghai Yuanye Biotechnology Co., Ltd. (China).

    Techniques: Expressing, Plasmid Preparation, Control, Fluorescence

    Journal: eLife

    Article Title: Multiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex

    doi: 10.7554/eLife.106510

    Figure Lengend Snippet:

    Article Snippet: Chemical compound , Opal 620 , Akoya Biosciences , FP1495001KT , 1:750 –1:1500.

    Techniques: