cgrp powder (MedChemExpress)
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MedChemExpress
cgrp powder
Cgrp Powder, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cgrp/%CE%B1-CGRP/pmc13112493-36-2-5
Average 94 stars, based on 14 article reviews
Cgrp Powder, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cgrp/%CE%B1-CGRP/pmc13112493-36-2-5
Average 94 stars, based on 14 article reviews
cgrp powder - by Bioz Stars,
2026-11
94/100 stars
Images
1) Product Images from "Corneal Nerves Promote Alkali Burn Repair by Modulating Macrophages and Neutrophils via Calcitonin Gene-Related Peptide"
Article Title: Corneal Nerves Promote Alkali Burn Repair by Modulating Macrophages and Neutrophils via Calcitonin Gene-Related Peptide
Journal: Investigative Ophthalmology & Visual Science
doi: 10.1167/iovs.67.4.60
Figure Legend Snippet: CGRP suppresses corneal tissue inflammation following alkali burn. ( A ) The volcano plot displayed the upregulated and downregulated genes in the corneas of mice from the CGRP-treated group compared with the PBS-treated group at 7 days post-injury ( n = 3). ( B ) The heatmap showed the differentially expressed genes in the corneas of mice from the CGRP-treated group compared with the PBS-treated group at 7 days post-injury ( n = 3). ( C ) The mRNA expression of the inflammatory factors IL-1β, iNOS, MCP-1, MMP3, and MMP9 was detected by qPCR on day 7 post-injury following CGRP treatment ( n = 4). ( D, E ) Representative flow cytometry plots and bar charts of CD45+ cells in the cornea after 7 days of treatment with CGRP following injury. ( F, G ) Representative micrographs and bar charts of macrophages in the cornea after 7 days treatment with topical CGRP or PBS ( n = 4). ( H ) Corneal macrophages were determined by flow cytometry ( n = 4). ( I, J ) Representative flow cytometry plots and bar charts of CD206+ macrophages in the cornea of the CGRP treatment group ( n = 4). ( K, L ) Representative micrographs and bar charts of neutrophils in the cornea after 7 days treatment with topical CGRP or PBS ( n = 4). (M) Corneal neutrophils were determined by flow cytometry ( n = 4). Data are shown as mean ± SD. ns: not significant; * P < 0.05; ** P < 0.01; *** P < 0.001.
Techniques Used: Expressing, Flow Cytometry
Figure Legend Snippet: Expression of the CGRP receptor in neutrophils and macrophages, and transcriptomic analysis of macrophages following CGRP treatment in vitro. ( A, B ) Light microscope image of bone marrow-derived macrophages and bone marrow-derived neutrophils ( n = 4). ( C ) CALCRL and RAMP1 expression was detected in bone marrow-derived macrophages and neutrophils using immunostaining. Green = CALCRL, red = RAMP1 ( n = 4). ( D ) Heatmap of selected significantly upregulated and downregulated genes depicting standardized gene expression values in CGRP-treated cells compared to PBS-treated cells. The colored circles next to the heatmap denote gene functions. ( E ) Volcano plot displaying upregulated and downregulated genes in macrophages from the CGRP-treated group versus the PBS-treated group. ( F ) GO enrichment analysis of significantly upregulated ( red ) and downregulated ( blue ) genes in CGRP-treated and saline-treated macrophages.
Techniques Used: Expressing, In Vitro, Light Microscopy, Derivative Assay, Immunostaining, Gene Expression, Saline
Related Articles
Sterility:Article Title: Corneal Nerves Promote Alkali Burn Repair by Modulating Macrophages and Neutrophils via Calcitonin Gene-Related Peptide Article Snippet: .. We dissolved Concentration Assay:Article Title: Corneal Nerves Promote Alkali Burn Repair by Modulating Macrophages and Neutrophils via Calcitonin Gene-Related Peptide Article Snippet: .. We dissolved other:Article Title: Calcitonin gene-related peptide inhibits macrophage migration and differentiation via the GTPase Rap1 Article Snippet: Selected sections were stained using haematoxylin and eosin (HE,Sigma-Aldrich), tartrate-resistant acid phosphatase (TRAP,Sigma-Aldrich), and Trichrome Stain (Masson) kits (Sigma-Aldrich) according to the manufacturer’s instructions. Article Title: CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. Article Snippet: Background: Calcitonin gene-related peptide (CGRP), a 37-amino-acid neuropeptide, is widely distributed in the central and peripheral nervous systems and participates in regulating various physiological and pathological processes such as vasodilation, inflammation, and pain.. Recent studies have shown that CGRP also exhibits neuroprotective effects, however, its role in epileptic neuronal damage remains unclear.. Methods: We conducted experiments on kainic acid (KA)-induced epileptic mice in vivo and glutamate induced neuronal cell death models in vitro, with treatments of CGRP and agonists or inhibitors of the corresponding receptors and pathway proteins. Article Title: Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity Article Snippet: Expressing:Article Title: Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via Ca 2+ signaling. Article Snippet: For hydrolysates, ADP (500 M, MCE, Cat# 257 HY-W010918) and adenosine (500 M, MCE, Cat# HY-B0228) were added to the 258 neuron cultures and incubated for 3 d. To identify signal transduction mechanisms and 259 transcription factors that regulate ATP-induced Piezo2 expression, inhibitors were 260 added and coincubated with ATP for 1 h. After changing the medium, the neurons were 261 treated with inhibitors for 72 h. The inhibitors that were used in this study includes T-262 5224 (50 M, APExBIO, Cat# B4664), 666-15 (100 nM, MCE Cat# HY-101120), BI-263 6015 (1.25 M, MCE, Cat# HY-108469), YC-1 (10 M, APExBIO, Cat# B7641), 264 cyclic pifithrin-α hydrobromide (20 M, APExBIO, Cat# A4477), SGC-CBP30 (100 265 nM, MCE, Cat# HY-15826), Go 6983 (100 nM, MCE, Cat# HY-13689), H89 (1 M, 266 APExBIO, Cat# B2190), SP600125 (1 M, MCE, Cat# HY-12041), SB203580 (10 M, 267 AR TIC LE IN PR ES S MCE, Cat# HY-10256A) and U0126 (10 M, MCE, Cat# HY-12031). .. Furthermore, |
