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mouse ccl21 (R&D Systems)

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R&D Systems mouse ccl21
Mouse Ccl21, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 23 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ccl21/Recombinant+Mouse+CCL21%2F6Ckine+Protein/pm41917325-386-9-13
Average 94 stars, based on 23 article reviews

mouse ccl21 - by Bioz Stars, 2026-10

94/100 stars

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Recombinant:

Article Title: The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes
Article Snippet: CFSE (5- or 6-(N-succinimidyloxycarbonyl)-fluorescein 3′,6′-diacetate), CMTMR ((5-(and 6)-(((4-chloromethyl)benzoyl)amino) tetramethylrhodamine), and CMF2HC (4-chloromethyl-6,8-difluoro-7-hydroxycoumarin) dye for cell labeling were obtained from Invitrogen. .. Recombinant CCL21 was purchased from R&D Systems and S1P and FTY720 were obtained from Cayman Chemicals. .. Cells (1−2 × 10 6 ) were stained with fluorescent antibodies in culture medium (Iscove′s Modified Dulbecco′s medium supplemented with 2-mercaptoethanol and 4% fetal calf serum (4% FCS IMDM) and analyzed with an Attune NxT Flow Cytometer (Thermo Fisher) or a FACS Canto II flow cytometer (BD Bioscience).

Article Title: The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes.
Article Snippet: CFSE (5- or 6-(N-succinimidyloxycarbonyl)-fluorescein 3′,6′-diacetate), CMTMR ((5-(and 6)-(((4-chloromethyl)benzoyl) amino) tetramethylrhodamine), and CMF2HC (4-chloromethyl6,8-difluoro-7-hydroxycoumarin) dye for cell labeling were obtained from Invitrogen. .. Recombinant CCL21 was purchased from R&D Systems and S1P and FTY720 were obtained from Cayman Chemicals. .. Cells (1−2 × 106) were stained with fluorescent antibodies in culture medium (Iscove′s Modified Dulbecco′s medium supplemented with 2-mercaptoethanol and 4% fetal calf serum (4% FCS IMDM) and analyzed with an Attune NxT Flow Cytometer (Thermo Fisher) or a FACS Canto II flow cytometer (BD Bioscience).

Concentration Assay:

Article Title: Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation
Article Snippet: Cell migration assays were performed using an 8.0 μm pore polycarbonate membrane insert plate Transwell® (Corning, Life Science #3422). .. BMDCs were added to the upper chambers and the ligands CCL19 (R&D System #440-M3-025) and CCL21 (R&D System #457-6C-025) were added to the lower chambers at a 50 ng/μL concentration. ..

other:

Article Title: The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4 + T cell tissue infiltration.
Article Snippet: Article The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration Highlights • SUB1 dictates the tissue infiltration of pathogenic CD4+ T cells • Sub1 expression is directly modulated by the TCR-IRF4 pathway • Sub1 deficiency prevents EAE onset by halving DOCK2 levels • SUB1 undergoes LLPS to open chromatin and drive the JUNB-DOCK2 transcriptional cascade Authors Xiaoxue Li, Wenhua Liang, Weifang Wang, Eilon Sherman, Keling Huang, Feng Wang Correspondence wangfeng16@sjtu.edu.cn In brief Blocking pathogenic T cell migration is crucial for treating autoimmune diseases.. Li et al. reveal SUB1 as a gatekeeper of CD4+ T cell infiltration in autoimmunity.. TCR-induced SUB1 drives Rac- dependent cytoskeletal remodeling via DOCK2 transcriptional activation.

Sterility:

Article Title: IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma.
Article Snippet: Article