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zveid fmk  (Tocris)


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    Tocris zveid fmk
    Zveid Fmk, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/zveid+fmk/Fmk/10__1128_slash_jvi__01999___10-65-12-15
    Average 93 stars, based on 8 article reviews
    zveid fmk - by Bioz Stars, 2026-09
    93/100 stars

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    Related Articles

    Incubation:

    Article Title: Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle
    Article Snippet: Evenly spread GFP-LAP2 HeLa cells grown in -slide eight-well dishes (Ibidi; ibiTreat) were washed in permeabilization buffer (PB) (20 mM HEPES KOH [pH 7.4], 110 mM potassium acetate [KOAc], 5 mM MgOAc, 0.5 mM EGTA, and 250 mM sucrose), permeabilized in PB containing 15 g/ml digitonin for 3 min, and then washed three times in PB for 2 min. Permeabilized cells were then incubated or mock incubated with MVM at a multiplicity of infection (MOI) of 4 PFU/cell in transport buffer (TB) (20 mM HEPES KOH [pH 7.3], 110 mM KOAc, 5 mM NaOAc, 1 mM EGTA, and 2 mM dithiothreitol [DTT]) containing 155-kDa tetramethyl rhodamine isocyanate (TRITC)-labeled dextran (250 g/ml) (Sigma-Aldrich) and visualized immediately on an Olympus Fluoview FV1000 laser scanning microscope at 37°C. .. Where indicated, the caspase inhibitor zVAD-fmk (200 M), zDEVD-fmk (50 M), or zVEID-fmk (50 M) (Tocris Biosciences) was included in the last washing step and the incubation/visualization step. .. Quantification of nuclear over extracellular fluorescence was performed by measuring the mean fluorescence intensity of a defined area (10 pixels by 10 pixels) in the nucleus and dividing by the mean intensity of an equal area outside the cell, using ImageJ software (National Institutes of Health).

    Article Title: Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle
    Article Snippet: For the phospholipase A2 (PLA2) inhibition experiment, MVM was incubated with 10 M manoalide (Alexis Biochemicals) for 1 h at room temperature with agitation prior to microinjection. .. Where indicated, a 50 mM concentration of the caspase inhibitor benzyloxycarbonylVal-Ala-Asp-fluoromethyl ketone (zVAD-fmk), zDEVD-fmk, or zVEID-fmk (Tocris Biosciences) was included in the MVM solution to be injected, resulting in an intracellular inhibitor concentration of approximately 200 M. Oocytes were then incubated at room temperature for 2 h, followed by fixation and preparation for thin-section electron microscopy (EM) as previously described (2, 5, 39). .. Quantification of the proportion of ONM damaged was performed using ImageJ software (National Institutes of Health).

    Article Title: Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle
    Article Snippet: .. The medium was then replaced, and cells were incubated at 37°C for 2, 15, or 21 h. Where indicated, the caspase inhibitor zVAD-fmk, zDEVD-fmk, or zVEID-fmk (Tocris Biosciences) was included in the medium for 1 h prior to infection and during the infection steps. ..

    Concentration Assay:

    Article Title: Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle
    Article Snippet: For the phospholipase A2 (PLA2) inhibition experiment, MVM was incubated with 10 M manoalide (Alexis Biochemicals) for 1 h at room temperature with agitation prior to microinjection. .. Where indicated, a 50 mM concentration of the caspase inhibitor benzyloxycarbonylVal-Ala-Asp-fluoromethyl ketone (zVAD-fmk), zDEVD-fmk, or zVEID-fmk (Tocris Biosciences) was included in the MVM solution to be injected, resulting in an intracellular inhibitor concentration of approximately 200 M. Oocytes were then incubated at room temperature for 2 h, followed by fixation and preparation for thin-section electron microscopy (EM) as previously described (2, 5, 39). .. Quantification of the proportion of ONM damaged was performed using ImageJ software (National Institutes of Health).

    Injection:

    Article Title: Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle
    Article Snippet: For the phospholipase A2 (PLA2) inhibition experiment, MVM was incubated with 10 M manoalide (Alexis Biochemicals) for 1 h at room temperature with agitation prior to microinjection. .. Where indicated, a 50 mM concentration of the caspase inhibitor benzyloxycarbonylVal-Ala-Asp-fluoromethyl ketone (zVAD-fmk), zDEVD-fmk, or zVEID-fmk (Tocris Biosciences) was included in the MVM solution to be injected, resulting in an intracellular inhibitor concentration of approximately 200 M. Oocytes were then incubated at room temperature for 2 h, followed by fixation and preparation for thin-section electron microscopy (EM) as previously described (2, 5, 39). .. Quantification of the proportion of ONM damaged was performed using ImageJ software (National Institutes of Health).

    Electron Microscopy:

    Article Title: Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle
    Article Snippet: For the phospholipase A2 (PLA2) inhibition experiment, MVM was incubated with 10 M manoalide (Alexis Biochemicals) for 1 h at room temperature with agitation prior to microinjection. .. Where indicated, a 50 mM concentration of the caspase inhibitor benzyloxycarbonylVal-Ala-Asp-fluoromethyl ketone (zVAD-fmk), zDEVD-fmk, or zVEID-fmk (Tocris Biosciences) was included in the MVM solution to be injected, resulting in an intracellular inhibitor concentration of approximately 200 M. Oocytes were then incubated at room temperature for 2 h, followed by fixation and preparation for thin-section electron microscopy (EM) as previously described (2, 5, 39). .. Quantification of the proportion of ONM damaged was performed using ImageJ software (National Institutes of Health).

    Infection:

    Article Title: Nuclear Envelope Disruption Involving Host Caspases Plays a Role in the Parvovirus Replication Cycle
    Article Snippet: .. The medium was then replaced, and cells were incubated at 37°C for 2, 15, or 21 h. Where indicated, the caspase inhibitor zVAD-fmk, zDEVD-fmk, or zVEID-fmk (Tocris Biosciences) was included in the medium for 1 h prior to infection and during the infection steps. ..



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    Effects of spinal injection of <t>CASP6</t> and TNF on naïve male and female mice. A Intrathecal injection of CASP6 (5 U) and TNF (20 ng) both elicited rapid and persistent mechanical hypersensitivity in naïve males. B Intrathecal injection of TNF but not CASP6 elicited rapid and persistent mechanical hypersensitivity in naïve females. Mean ± SEM; *P < 0.05, n.s., not significant, two-way ANOVA; n = 4 mice per group; BL, baseline. Arrows indicate drug injection.
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    Image Search Results


    KEY RESOURCES TABLE

    Journal: Cell reports

    Article Title: Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

    doi: 10.1016/j.celrep.2020.107839

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: At 12 or 18 hours after viral infection, GSI or caspase inhibitors were added to the OTSCs: 10 μM DAPT (565770, EMD Biosciences), 10 μM zVAD (FMK001, pan-caspase inhibitor, R&D Systems), 10 μM zDEVD (FMK004, caspase-3 inhibitor, R&D Systems), 10 μM zYVAD (FMK005, caspase-4 inhibitor, R&D Systems), 10 μM zVEID (FMK006, caspase-6 inhibitor, R&D Systems), and 10 μM zIETD (FMK007, caspase-8 inhibitor, R&D Systems).

    Techniques: Virus, Recombinant, Plasmid Preparation, Protease Inhibitor, Transfection, Software, Cell Culture

    Effects of spinal injection of CASP6 and TNF on naïve male and female mice. A Intrathecal injection of CASP6 (5 U) and TNF (20 ng) both elicited rapid and persistent mechanical hypersensitivity in naïve males. B Intrathecal injection of TNF but not CASP6 elicited rapid and persistent mechanical hypersensitivity in naïve females. Mean ± SEM; *P < 0.05, n.s., not significant, two-way ANOVA; n = 4 mice per group; BL, baseline. Arrows indicate drug injection.

    Journal: Neuroscience Bulletin

    Article Title: Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

    doi: 10.1007/s12264-017-0145-y

    Figure Lengend Snippet: Effects of spinal injection of CASP6 and TNF on naïve male and female mice. A Intrathecal injection of CASP6 (5 U) and TNF (20 ng) both elicited rapid and persistent mechanical hypersensitivity in naïve males. B Intrathecal injection of TNF but not CASP6 elicited rapid and persistent mechanical hypersensitivity in naïve females. Mean ± SEM; *P < 0.05, n.s., not significant, two-way ANOVA; n = 4 mice per group; BL, baseline. Arrows indicate drug injection.

    Article Snippet: Recombinant full-length active human caspase-6 protein (CASP6) was from Abcam (Cambridge, MA), the CASP6 inhibitor Z-V-E(OMe)-I-D(OMe)-FMK (ZVEID) and TNF were from R&D Systems (Minneapolis, MN).

    Techniques: Injection

    CASP6 contributes to formalin-induced pain and late-phase mechanical hypersensitivity in male mice. A Time course of formalin-induced pain in males and females with intrathecal vehicle or the CASP6 inhibitor ZVEID (30 µg). B ZVEID (30 µg, i.t.) reduced both formalin-induced phase I and phase II pain in males but only phase I in females. *P < 0.05, two-tailed Student’s t-test, n = 5 mice per group. C, D Formalin-induced pain was reduced in male but not female Casp6 –/– mice. Mean ± SEM; *P < 0.05, two-tailed Student’s t-test, n = 4–5 mice per group. E Formalin-induced mechanical hypersensitivity in the late phase was lower in male than in female Casp6 –/– mice. Mean ± SEM; *P < 0.05, two-way ANOVA; n = 4–5 mice per group.

    Journal: Neuroscience Bulletin

    Article Title: Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

    doi: 10.1007/s12264-017-0145-y

    Figure Lengend Snippet: CASP6 contributes to formalin-induced pain and late-phase mechanical hypersensitivity in male mice. A Time course of formalin-induced pain in males and females with intrathecal vehicle or the CASP6 inhibitor ZVEID (30 µg). B ZVEID (30 µg, i.t.) reduced both formalin-induced phase I and phase II pain in males but only phase I in females. *P < 0.05, two-tailed Student’s t-test, n = 5 mice per group. C, D Formalin-induced pain was reduced in male but not female Casp6 –/– mice. Mean ± SEM; *P < 0.05, two-tailed Student’s t-test, n = 4–5 mice per group. E Formalin-induced mechanical hypersensitivity in the late phase was lower in male than in female Casp6 –/– mice. Mean ± SEM; *P < 0.05, two-way ANOVA; n = 4–5 mice per group.

    Article Snippet: Recombinant full-length active human caspase-6 protein (CASP6) was from Abcam (Cambridge, MA), the CASP6 inhibitor Z-V-E(OMe)-I-D(OMe)-FMK (ZVEID) and TNF were from R&D Systems (Minneapolis, MN).

    Techniques: Two Tailed Test