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Mendeley Ltd
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Amira Pharmaceuticals
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Pacific Biosciences
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Pacific Biosciences
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Baxter Healthcare
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Exosome Diagnostics
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Novartis
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10X Genomics
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Sentieon Inc
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Exosome Diagnostics
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Journal: Clinical, Cosmetic and Investigational Dermatology
Article Title: Exosomes in Psoriasis: From Pathogenic Mechanisms to Therapeutic Innovations
doi: 10.2147/CCID.S606845
Figure Lengend Snippet: Proposed workflow for exosome‑based clinical diagnostics in psoriasis. The workflow follows MISEV2023 guidelines and includes (1) sample collection (plasma, urine or tissue, processed on ice within 1 h); (2) EV separation (differential ultracentrifugation plus iodixanol density gradient); (3) orthogonal quality control (NTA, TEM, EV markers CD9/CD63/CD81/ALIX/TSG101, and exclusion of non‑EV contaminants such as calnexin); (4) molecular profiling (qRT‑PCR or ddPCR for exosomal miRNAs or mRNAs); and (5) clinical interpretation (ROC‑derived cut‑offs, composite scores with PASI/CRP, independent validation). No exosome‑based psoriasis test has yet received regulatory clearance.
Article Snippet:
Techniques: Clinical Proteomics, Control, Biomarker Discovery