vx 770 (MedChemExpress)
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MedChemExpress
vx 770
Vx 770, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 40 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vx+770/Ivacaftor/bio_rxiv__64898__2026__07__26__740036-241-7-8
Average 95 stars, based on 40 article reviews
Vx 770, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 40 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/vx+770/Ivacaftor/bio_rxiv__64898__2026__07__26__740036-241-7-8
Average 95 stars, based on 40 article reviews
vx 770 - by Bioz Stars,
2026-09
95/100 stars
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other:Article Title: Additive Potentiation of R334W-CFTR Function by Novel Small Molecules Article Snippet: The remaining compounds were purchased from commercial sources at the analytical grade: VX-770 (#HY-13017), genistein (#HY-14596), forskolin (Fsk, #HY-15371), and Article Title: Additive Potentiation of R334W-CFTR Function by Novel Small Molecules. Article Snippet: The remaining compounds were purchased from commercial sources at the analytical grade: VX-770 (#HY-13017), genistein (#HY-14596), forskolin (Fsk, #HY-15371), and Article Title: Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations Article Snippet: Concentration Assay:Article Title: CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells Article Snippet: Reduced Glutathione (GSH, Sigma) was added as a fresh 10 mm solution in BEGM-EGF to the apical and basolateral side, the apical medium was removed after 20 min. Deferoxamine (DFO) solubilized in PBS was added to 100 μM (HBEC-ALI) or 50 μM (Pig BEC-ALI). .. Lumacaftor/ivacaftor (a.k.a OrkambiTM) treatment was simulated by adding 2 μM VX-809 and 0.01 μM Incubation:Article Title: Chiral Resolution, stereochemical assignment and correction of a cystic fibrosis-causing variant of Aryl-Triazolyl-methanol derivative Article Snippet: This study details the preparative chiral resolution of the aryl-triazolyl-methanol compound (4-bromophenyl)(1(4-bromophenyl)-1H-1,2,3-triazol-4-yl)methanol using a ChiralCel OZ column with a mobile phase of hexanes and isopropanol (90:10).. Single-crystal X-ray diffraction was used to confirm that the enantiomer with a longer retention time, designated LSO172, has the (R) absolute configuration.. Both enantiomers were evaluated for their ability to rescue the trafficking of the p.Phe508del-CFTR protein, a key variant in cystic fibrosis. Saline:Article Title: Chiral Resolution, stereochemical assignment and correction of a cystic fibrosis-causing variant of Aryl-Triazolyl-methanol derivative Article Snippet: This study details the preparative chiral resolution of the aryl-triazolyl-methanol compound (4-bromophenyl)(1(4-bromophenyl)-1H-1,2,3-triazol-4-yl)methanol using a ChiralCel OZ column with a mobile phase of hexanes and isopropanol (90:10).. Single-crystal X-ray diffraction was used to confirm that the enantiomer with a longer retention time, designated LSO172, has the (R) absolute configuration.. Both enantiomers were evaluated for their ability to rescue the trafficking of the p.Phe508del-CFTR protein, a key variant in cystic fibrosis. |