streptococcus pneumoniae atcc 6305 α haemolysis  (ATCC)

Journal: Frontiers in Microbiology

Article Title: Functional heterogeneity and health impacts of oral bacterial ectopic colonization

doi: 10.3389/fmicb.2026.1915341

Figure Lengend Snippet: Evidence-based evaluation of oral bacterial ectopic colonization across selected systemic conditions.

Article Snippet: However, in acute polymicrobial infection, an intratracheal co-infection murine model provided experimental evidence of pathogenic synergy: mice co-inoculated with Streptococcus pneumoniae and Prevotella intermedia (ATCC 25611) exhibited significantly lower survival rates, elevated pulmonary and systemic bacterial burdens, and aggravated cytokine storms in bronchoalveolar lavage fluid ( ).

Techniques: Binding Assay, Biomarker Discovery, In Vivo, Metagenomics, In Vitro, Inhibition, Animal Model, Mouse Assay, Mutagenesis, Knock-Out, Infection, Profiling, Diagnostic Assay, Translocation Assay, Expressing, Xenograft Assay, Isolation, Disruption, Transmission Assay, Polymerase Chain Reaction, Cell Culture

Journal: Frontiers in Microbiology

Article Title: Functional heterogeneity and health impacts of oral bacterial ectopic colonization

doi: 10.3389/fmicb.2026.1915341

Figure Lengend Snippet: Systemic distribution, ecological niches, and disease associations of Prevotella species across experimental and clinical domains. Schematic overview illustrating the site-specific functional divergence and origin attribution of representative Prevotella lineages across human organ systems. Oral Cavity: Prevotella intermedia subgingival overgrowth is clinically enriched in stage III periodontitis cohorts, whereas commensal Prevotella nanceiensis and Prevotella melaninogenica in saliva correlate with caries resistance in prospective pediatric cohorts. Respiratory Tract upregulates host epithelial PAFR transcription and secretes cysteine endopeptidases, experimentally accelerating Streptococcus pneumoniae adherence, transmigration, and bacteremic pneumonia in murine co-infection models. Gastrointestinal Tract: Oral-derived Prevotella histicola suppresses mucosal IRE1 α -JNK endoplasmic reticulum stress and NF- κ B signaling, demonstrating protective anti-inflammatory efficacy in murine DSS-colitis models; in contrast, overgrowth of the indigenous colonic Prevotella copri complex correlates with diarrhea-predominant IBS in human 16S rRNA surveys. Female Reproductive Tract: Indigenous vaginal species Prevotella timonensis and Prevotella bivia abundantly express sialidases linked to cervical mucosal barrier breakdown in bacterial vaginosis and adverse pregnancy outcomes ( not oral-derived ). Joints: Intestinal expansion of P. copri exacerbates Th17-driven arthritis in genetically susceptible SKG mice, though human rheumatoid arthritis (RA) data remain correlative. Vascular System: Oral Prevotella spp. act as opportunistic bloodstream isolates in vulnerable patients with infective endocarditis. Created in BioRender.com . ATCC, American Type Culture Collection; BDM, brittle diabetes mellitus; BV, bacterial vaginosis; DSS, dextran sulfate sodium; IBD, inflammatory bowel disease; IBS-D, diarrhea-predominant irritable bowel syndrome; IRE1 α , inositol-requiring enzyme 1 α ; JNK, c-Jun N-terminal kinase; NF- κ B, nuclear factor kappa B; PAFR, platelet-activating factor receptor; RA, rheumatoid arthritis; Th17, T-helper 17 cell.

Article Snippet: However, in acute polymicrobial infection, an intratracheal co-infection murine model provided experimental evidence of pathogenic synergy: mice co-inoculated with Streptococcus pneumoniae and Prevotella intermedia (ATCC 25611) exhibited significantly lower survival rates, elevated pulmonary and systemic bacterial burdens, and aggravated cytokine storms in bronchoalveolar lavage fluid ( ).

Techniques: Functional Assay, Transmigration Assay, Infection, Derivative Assay