npcs (MedChemExpress)
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MedChemExpress
npcs
Npcs, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sting+agonist/diABZI+STING+agonist-1/pm42816544-64-6-15
Average 95 stars, based on 34 article reviews
Npcs, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sting+agonist/diABZI+STING+agonist-1/pm42816544-64-6-15
Average 95 stars, based on 34 article reviews
npcs - by Bioz Stars,
2026-10
95/100 stars
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other:Article Title: Sevoflurane-induced neurotoxicity in neonatal mice is driven by microglial ferroptosis via MSTRG.7388-dependent NCOA4/STING axis. Article Snippet: Preclinical investigations have indicated that recurrent sevoflurane exposure induces long-term cognitive deficits in neonatal mice while the effects of inhalational anesthetics on children remain ambiguous.. In the current study, Our comprehensive analysis of single-nucleus transcriptomics-guided competing endogenous RNA (ceRNA) networks revealed long-stranded ncRNA (lncRNA) MSTRG.7388 as a pivotal modulator in sevoflurane-mediated cognitive impairment, regulating microglial activation through the inhibition of microRNA miR-410-3p and the promotion of nuclear receptor coactivator 4 (NCOA4) expression.. Furthermore, we elucidated that mutual binding of NCOA4 and stimulator of interferon genes (STING) dimers induced microglial ferroptosis independent of the ubiquitination pathway and long-term cognitive impairment in mice exposed to sevoflurane. Article Title: PLSCR3 Deficiency Triggers mtDNA‐Driven cGAS‐STING Activation to Potentiate Antitumor Immunity in Colorectal Cancer Article Snippet: STING agonist (Cat. No. HY‐103665, CAS No.: 2138299‐29‐1) and Article Title: Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity Article Snippet: All culture media were supplemented with 10% fetal bovine serum (FBS; Hyclone, Logan, UT, USA) and 100 U mL −1 penicillin‐streptomycin. Article Title: Osteoclastogenesis Responds to
<scp>STING</scp>
Inhibition in a Non‐Monotonic Manner Article Snippet: Recent studies have indicated the paradoxical roles of stimulator of interferon genes (STING) in bone metabolism, which obscures targeting STING to treat osteoporosis.. Here, by integrating ovariectomy (OVX)induced osteoporosis models, osteoblastspecific Sting knockout mice, and staged in vitro osteoclastogenesis models, we report that STING temporally regulates osteoclast differentiation without participating in osteoblastmediated bone homeostasis.. Through the timed administration of the STING inhibitor C176, we found a nonmonotonic bone response to STING inhibition in OVX mice. Control:Article Title: Mass Cytometry‐Based Approach for the Investigation of Stimulator of Interferon Genes Pathway Article Snippet: The heatmap in Figure was generated using GraphPad Prism (version 10.5.0, GraphPad Software), and the heatmap in Figure was generated using Cytobank. .. Indicated cell lines or PBMCs were seeded for 2 h onto coverslips pre‐coated with Poly‐L‐Lysine (0.1 mg/mL, Sigma, # L8662) and stimulated for 6 h at 37°C in 5% CO 2 with 10 μg/mL of the Concentration Assay:Article Title: Oxidative stress-induced release of mitochondrial DNA (mtDNA) promotes the progression of vitiligo by activating the cGAS-STING signaling pathway in monocytes. Article Snippet: Vitiligo, driven by cytotoxic CD8 T cells destroying melanocytes, has recently been linked to mitochondrial DNA (mtDNA), a DAMP known to trigger innate immunity.. However, the precise role of mtDNA in vitiligo pathogenesis remains poorly understood.. In this study, we observed significantly elevated mtDNA levels in both the serum and depigmented lesions of vitiligo patients. Encapsulation:Article Title: Sting agonist comprising exosomes for treating neuroimmunological disorders Article Snippet: The exosome fraction will be diluted in −32 mL PBS in a 38.5 mL Ultra-Clear (344058) tube and ultracentrifuged at 133,900×g for 3 hours at 4° C. to pellet the purified exosomes. .. The pelleted exosomes will be then resuspended in a minimal volume of PBS ( ̃200 μL) and stored at 4° C. Encapsulation of Incubation:Article Title: Sting agonist comprising exosomes for treating neuroimmunological disorders Article Snippet: The exosome fraction will be diluted in −32 mL PBS in a 38.5 mL Ultra-Clear (344058) tube and ultracentrifuged at 133,900×g for 3 hours at 4° C. to pellet the purified exosomes. .. The pelleted exosomes will be then resuspended in a minimal volume of PBS ( ̃200 μL) and stored at 4° C. Encapsulation of Purification:Article Title: Sting agonist comprising exosomes for treating neuroimmunological disorders Article Snippet: The exosome fraction will be diluted in −32 mL PBS in a 38.5 mL Ultra-Clear (344058) tube and ultracentrifuged at 133,900×g for 3 hours at 4° C. to pellet the purified exosomes. .. The pelleted exosomes will be then resuspended in a minimal volume of PBS ( ̃200 μL) and stored at 4° C. Encapsulation of |